Neuropsychological deficits in female adolescents with a substance use disorder: better accounted for by conduct disorder?

2000 ◽  
Vol 61 (6) ◽  
pp. 809-817 ◽  
Author(s):  
P R Giancola ◽  
A C Mezzich
2014 ◽  
Vol 21 (9) ◽  
pp. 776-782 ◽  
Author(s):  
Judith S. Brook ◽  
Elinor B. Balka ◽  
Chenshu Zhang ◽  
David W. Brook

Objective: To assess whether the relationship of an ADHD diagnosis by adolescence to nonprescription stimulant use in adulthood is direct or indirect, via Conduct Disorder (CD) and/or Substance Use Disorder (SUD). Method: Data were obtained from multiple waves of interviews and questionnaires completed by 551 community-based participants when they were between the mean ages of 14.1 and 36.6 years. Results: The results of the structural equation model (SEM) supported both a direct association between early ADHD and later nonprescription stimulant use ( B = .18, z = 2.74) and the relationship from ADHD to later nonprescription stimulant use ( B = .01, z = 1.72) via CD and SUD. Conclusion: The longitudinal data supporting these paths suggest that efforts to prevent and treat the misuse of nonprescription stimulants may be more effective if attention is paid to those with a history of ADHD, as well as to those who also had CD and SUD.


1995 ◽  
Vol 40 (6) ◽  
pp. 313-319 ◽  
Author(s):  
P Reebye ◽  
Mm Moretti ◽  
Jc Lessard

Objective To examine the rate of comorbidity between conduct disorder and substance use disorder in a clinical sample using the Diagnostic Interview for Children and Adolescents - Revised. Method Examined the pattern of conduct disorder symptoms, including type, number, and severity, in conduct-disordered youth diagnosed with, and without a comorbid substance use disorder. Results The examination revealed no significant differences in the incidence of comorbidity between younger (aged 10 to 13) and older (above age 13) youth. Among youth who met criteria for conduct disorder, 52% also met criteria for a substance use disorder. Odds ratios indicated that the probability of comorbidity of conduct and substance use disorders was higher in the younger group. Conclusion Substance abuse and dependence tend to develop rapidly following first use, suggesting that a slim window of opportunity exists to prevent substance disorders once drug use has begun.


2016 ◽  
Vol 23 (12) ◽  
pp. 1438-1453 ◽  
Author(s):  
Sharlene Kaye ◽  
Josep Antoni Ramos-Quiroga ◽  
Geurt van de Glind ◽  
Frances R. Levin ◽  
Stephen V. Faraone ◽  
...  

Objective: To examine ADHD symptom persistence and subtype stability among substance use disorder (SUD) treatment seekers. Method: In all, 1,276 adult SUD treatment seekers were assessed for childhood and adult ADHD using Conners’ Adult ADHD Diagnostic Interview for Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV; CAADID). A total of 290 (22.7%) participants met CAADID criteria for childhood ADHD and comprise the current study sample. Results: Childhood ADHD persisted into adulthood in 72.8% ( n = 211) of cases. ADHD persistence was significantly associated with a family history of ADHD, and the presence of conduct disorder and antisocial personality disorder. The combined subtype was the most stable into adulthood (78.6%) and this stability was significantly associated with conduct disorder and past treatment of ADHD. Conclusion: ADHD is highly prevalent and persistent among SUD treatment seekers and is associated with the more severe phenotype that is also less likely to remit. Routine screening and follow-up assessment for ADHD is indicated to enhance treatment management and outcomes.


2013 ◽  
Vol 203 (2) ◽  
pp. 112-119 ◽  
Author(s):  
Annabeth P. Groenman ◽  
Jaap Oosterlaan ◽  
Nanda N. J. Rommelse ◽  
Barbara Franke ◽  
Corina U. Greven ◽  
...  

BackgroundAttention-deficit hyperactivity disorder (ADHD) is linked to increased risk for substance use disorders and nicotine dependence.AimsTo examine the effects of stimulant treatment on subsequent risk for substance use disorder and nicotine dependence in a prospective longitudinal ADHD case–control study.MethodAt baseline we assessed ADHD, conduct disorder and oppositional defiant disorder. Substance use disorders, nicotine dependence and stimulant treatment were assessed retrospectively after a mean follow-up of 4.4 years, at a mean age of 16.4 years.ResultsStimulant treatment of ADHD was linked to a reduced risk for substance use disorders compared with no stimulant treatment, even after controlling for conduct disorder and oppositional defiant disorder (hazard ratio (HR) = 1.91, 95% Cl 1.10−3.36), but not to nicotine dependence (HR = 1.12, 95% Cl 0.45−2.96). Within the stimulant-treated group, a protective effect of age at first stimulant use on substance use disorder development was found, which diminished with age, and seemed to reverse around the age of 18.ConclusionsStimulant treatment appears to lower the risk of developing substance use disorders and does not have an impact on the development of nicotine dependence in adolescents with ADHD.


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