scholarly journals The Effects of Foeniculum vulgare Seed Extract on Fertility Results of Assisted Reproductive Technology in Women With Poor Ovarian Response

2020 ◽  
Vol 8 (2) ◽  
pp. 203-208
Author(s):  
Mahnaz Yavangi ◽  
Ilnaz Mohammadi ◽  
Shahedeh Khansari ◽  
Shirin Moradkhani ◽  
Tayebe Artimani ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Endometrial Thickness ◽  
Ovarian Response ◽  
Reproductive Technology ◽  
Seed Extract ◽  
Poor Ovarian Response ◽  
Foeniculum Vulgare ◽  
Positive Effects ◽  
Significant Difference ◽  
Before And After

Objectives: Foeniculum vulgare due to phytoestrogens is important in the treatment of female sexual dysfunction including infertility. Accordingly, this study was conducted to investigate the effect of the F. vulgare seed extract on the fertility results of assisted reproductive technology (ART) in women with a poor ovarian response (POR). Materials and Methods: In this before-after intervention, 19 infertile women with POR were enrolled by a convenience sampling method. T h e amounts of luteinizing hormone ( LH) and follicle-stimulating hormone (FSH), ovarian ultrasound volume, the number of preantral follicles, and the size of the prominent ovary were measured before treatment with F. vulgare. Then, patients were treated with F. vulgare for two months, followed by initiating the in vitro fertilization (IVF) cycle. The number of embryos transferred in previous and current cycles was investigated after IVF. Finally, the data were analyzed in SPSS 16. Results: There was a significant difference in the serum LH level (P=0.002), LH/FSH (P=0.049), the number of follicles and ovules (P=0.003), endometrial thickness (P=0.04), and ovarian volume (P=0.03) between before and after treatment with F. vulgare. Moreover, a significant difference regarding the decreased number of required days for induction was observed between before and after treatment with F. vulgare (P=0.022). Conclusions: In general, the use of F. vulgare had positive effects on improving t h e quality of oocytes and female fertility indices in women with POR.

scholarly journals Effect of follicular flushing on reproductive outcomes in patients with poor ovarian response undergoing assisted reproductive technology

2017 ◽  
Vol 34 (10) ◽  
pp. 1353-1357 ◽  
Author(s):  
Anna L M Souza ◽  
Marcos Sampaio ◽  
Graciele B Noronha ◽  
Ludiana G R Coster ◽  
Roberta S G de Oliveira ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Ovarian Response ◽  
Reproductive Technology ◽  
Reproductive Outcomes ◽  
Poor Ovarian Response

scholarly journals Effects Of Hormonal Supplements In Women With Poor Ovarian Response Undergoing Assisted Reproductive Technology

2019 ◽  
pp. 1 ◽  
Author(s):  
Silan Melis Bozan ◽  
Gurkan Bozdag
Keyword(s):  
Growth Hormone ◽  
Assisted Reproductive Technology ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Ovarian Response ◽  
Reproductive Technology ◽  
Poor Responders ◽  
Poor Ovarian Response ◽  
Technology Cycles

<p>Poor ovarian response remains one of the major challenges of assisted reproductive technology. Over the years, various interventions have been proposed to improve reproductive outcomes in poor responders, yet few have been shown to be beneficial. Recent studies indicate that hormonal pretreatments might increase clinical pregnancy rate, live birth rate and the number of oocytes retrieved in women with poor ovarian response undergoing assisted reproductive technology. Areas covered: Following extensive research of the up to date literature, this review aims to cover current considerations and controversies regarding the use of hormonal supplements such as dehydroepiandrosterone, transdermal testosterone and growth hormone. Expert opinion: There is limited data for the validity of using growth hormone and androgens or androgen modulating agents during assisted reproductive technology cycles in women suffering from poor ovarian response. However, there is a need to support the available data with further randomized controlled trials seeking for live birth rate as the primary outcome.</p>

scholarly journals Comparative effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) versus highly purified urinary human menopausal gonadotropin (hMG HP) in assisted reproductive technology (ART) treatments: a non-interventional study in Germany

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Klaus F. Bühler ◽  
Robert Fischer ◽  
Patrice Verpillat ◽  
Arthur Allignol ◽  
Sandra Guedes ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Live Birth ◽  
Pregnancy Loss ◽  
Follicle Stimulating Hormone ◽  
Reproductive Technology ◽  
Clinical Pregnancy ◽  
Human Menopausal Gonadotropin ◽  
Ongoing Pregnancy ◽  
Complete Cycle ◽  
Significant Difference

Abstract Background This study compared the effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa; GONAL-f®) with urinary highly purified human menopausal gonadotropin (hMG HP; Menogon HP®), during assisted reproductive technology (ART) treatments in Germany. Methods Data were collected from 71 German fertility centres between 01 January 2007 and 31 December 2012, for women undergoing a first stimulation cycle of ART treatment with r-hFSH-alfa or hMG HP. Primary outcomes were live birth, ongoing pregnancy and clinical pregnancy, based on cumulative data (fresh and frozen-thawed embryo transfers), analysed per patient (pP), per complete cycle (pCC) and per first complete cycle (pFC). Secondary outcomes were pregnancy loss (analysed per clinical pregnancy), cancelled cycles (analysed pCC), total drug usage per oocyte retrieved and time-to-live birth (TTLB; per calendar week and per cycle). Results Twenty-eight thousand six hundred forty-one women initiated a first treatment cycle (r-hFSH-alfa: 17,725 [61.9%]; hMG HP: 10,916 [38.1%]). After adjustment for confounding variables, treatment with r-hFSH-alfa versus hMG HP was associated with a significantly higher probability of live birth (hazard ratio [HR]-pP [95% confidence interval (CI)]: 1.10 [1.04, 1.16]; HR-pCC [95% CI]: 1.13 [1.08, 1.19]; relative risk [RR]-pFC [95% CI]: 1.09 [1.05, 1.15], ongoing pregnancy (HR-pP [95% CI]: 1.10 [1.04, 1.16]; HR-pCC [95% CI]: 1.13 [1.08, 1.19]; RR-pFC [95% CI]: 1.10 [1.05, 1.15]) and clinical pregnancy (HR-pP [95% CI]: 1.10 [1.05, 1.14]; HR-pCC [95% CI]: 1.14 [1.10, 1.19]; RR-pFC [95% CI]: 1.10 [1.06, 1.14]). Women treated with r-hFSH-alfa versus hMG HP had no statistically significant difference in pregnancy loss (HR [95% CI]: 1.07 [0.98, 1.17], were less likely to have a cycle cancellation (HR [95% CI]: 0.91 [0.84, 0.99]) and had no statistically significant difference in TTLB when measured in weeks (HR [95% CI]: 1.02 [0.97, 1.07]; p = 0.548); however, r-hFSH-alfa was associated with a significantly shorter TTLB when measured in cycles versus hMG HP (HR [95% CI]: 1.07 [1.02, 1.13]; p = 0.003). There was an average of 47% less drug used per oocyte retrieved with r-hFSH-alfa versus hMG HP. Conclusions This large (> 28,000 women), real-world study demonstrated significantly higher rates of cumulative live birth, cumulative ongoing pregnancy and cumulative clinical pregnancy with r-hFSH-alfa versus hMG HP.

scholarly journals The Effects of Subcutaneous Administration of Granulocyte Colony-Stimulating Factor on Pregnancy Outcome After Assisted Reproductive Technology: Clinical Trial

2018 ◽  
Vol 6 (2) ◽  
pp. 31-36
Author(s):  
Marzie Farimani ◽  
Narges Mehrabi ◽  
Azar Pirdehghan ◽  
Maryam Bahmanzadeh
Keyword(s):  
Placebo Group ◽  
Assisted Reproductive Technology ◽  
Pregnancy Outcome ◽  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Subcutaneous Administration ◽  
Reproductive Technology ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

Background: Granulocyte-colony stimulating factor (G-CSF) is an innovative therapy in reproductive medicine. Although its mechanisms of action have remained unknown, G-CSF seems to be effective in the case of recurrent abortion or implantation failure and thin endometrium. Objectives: This study was conducted to investigate whether subcutaneous administration of G-CSF has any effect on pregnancy outcome after assisted reproductive technology (ART). Methods: Fifty women with male infertility factors undergoing ART treatment were enrolled and stimulated with the standard long protocol. The G-CSF group of women received one dose of subcutaneous G-CSF (Filgrastim, 300 µg/1 mL) on the day of embryo transfer and again two days later while the placebo group received normal saline. Results: Seventeen patients had a positive β-human chorionic gonadotropin concentration after embryo transfer (8 and 9 in G-CSF and placebo groups, respectively) although the difference was not statistically significant. In addition, spontaneous abortion occurred in three patients (1 patient in the G-CSF group vs. 2 patients in the placebo group). Conclusion: Overall, although G-CSF failed to affect the endometrial thickness, as well as implantation, or clinical pregnancy rates, a lower prevalence of abortion in G-CSF group may be due to the positive effect of G-CSF administration on the endometrium as compared to the placebo group.

scholarly journals The Role of Acupuncture in Assisted Reproductive Technology

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Cui Hong Zheng ◽  
Ming Min Zhang ◽  
Guang Ying Huang ◽  
Wei Wang
Keyword(s):  
Assisted Reproductive Technology ◽  
Meta Analysis ◽  
Live Birth Rate ◽  
Sham Acupuncture ◽  
Reproductive Technology ◽  
Laser Acupuncture ◽  
Vitro Fertilization ◽  
Positive Effects

The aim of this paper was to provide reliable evidence by performing a systematic review and meta-analysis for evaluating the role of acupuncture in assisted reproductive technology. All randomized controlled trials that evaluated the effects of acupuncture, including manual, electrical, and laser acupuncture (LA) techniques, on the clinical pregnancy rate (CPR) and live birth rate (LBR) of in vitro fertilization (IVF) or artificial insemination were included. The controlled groups consisted of no acupuncture and sham acupuncture groups. The sham acupuncture included sham acupuncture at acupoints, sham acupuncture at non- or inappropriate points, sham LA, and adhesive tapes. Twenty-three trials (a total of 5598 participants) were included in this paper. The pooled CPR from all acupuncture groups was significantly higher than that from all controlled groups, whereas the LBR was not significantly different between the two groups. However, the results were quite distinct when the type of control and/or different acupuncture times were examined in a sensitivity analysis. The results mainly indicate that acupuncture, especially around the time of the controlled ovarian hyperstimulation, improves pregnancy outcomes in women undergoing IVF. More positive effects from acupuncture in IVF can be expected if a more individualized acupuncture programs are used.

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