CLINICAL EVALUATION OF THE THYROID STIMULATING HORMONE ACTIVITY IN EXOPHTHALMOS

1961 ◽  
Vol 38 (4) ◽  
pp. 577-584 ◽  
Author(s):  
Sven Erik Björkman ◽  
Torsten Denneberg ◽  
Inge Hedenskog
Keyword(s):  
Clinical Evaluation ◽  
Thyroid Stimulating Hormone ◽  
Significant Rise ◽  
Hormone Activity ◽  
Control Subjects ◽  
Long Duration ◽  
Stimulating Factor ◽  
Stimulating Hormone

ABSTRACT A method for demonstrating the presence of a thyroid stimulating factor in the blood of patients with progressive exophthalmos after thyroidectomy or after treatment with radioiodine is described. The method consists of transfusing freshly drawn blood from the patients to euthyroid recipients and subsequently following the PBI level of the recipients at regular intervals. Six exophthalmic patients tested in this manner were found to have such a factor in their circulating blood. After transfusion of their blood a significant rise in the PBI level of the recipients could be demonstrated. Two other patients, one with exophthalmos of long duration did not show this response nor did it occur after transfusion of blood from two control subjects. In one case the action of this factor was compared with that of animal thyrotrophin and found to be of the same magnitude.

scholarly journals Clinical evaluation of highly sensitive thyroid stimulating hormone immunoradiometric assay (RIABEAD II) kit.

RADIOISOTOPES ◽  
1988 ◽  
Vol 37 (2) ◽  
pp. 95-98
Author(s):  
Kyuzi KAMOI ◽  
Kenzo KANEKO ◽  
Katsumi MATSUNAGA ◽  
Michiko YAMAZAKI ◽  
Shoei MURAYAMA ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Thyroid Stimulating Hormone ◽  
Immunoradiometric Assay ◽  
Highly Sensitive ◽  
Stimulating Hormone

ELECTROPHORETIC SEPARATION OF HORMONES ASSOCIATED WITH SECRETORY GRANULES FROM RAT ANTERIOR PITUITARY GLANDS

1970 ◽  
Vol 63 (2) ◽  
pp. 378-384 ◽  
Author(s):  
D. R. Hodges ◽  
W. H. McShan
Keyword(s):  
Growth Hormone ◽  
Anterior Pituitary ◽  
Secretory Granules ◽  
Follicle Stimulating Hormone ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Disc Electrophoresis ◽  
Hormone Activity ◽  
Pituitary Glands ◽  
Stimulating Hormone

ABSTRACT Electrophoretic analyses of rat, mouse, human and cow anterior pituitary homogenates with subsequent bioassays for hormonal activity have been reported. Comparison of the behaviour of the hormonal activities from rat anterior pituitary secretory granules and that reported for pituitary homogenates was made following disc electrophoresis on polyacrylamide gels. Bioassays of gel segments for the six anterior pituitary hormones resulted in the localization of the activities of five of the six hormones. ACTH activity was not detected. Growth hormone and prolactin were associated with the major cathodal and anodal discs respectively. Luteinizing hormone and thyroid stimulating hormone activities had similar mobilities and were located in a zone just above growth hormone. The activity was not restricted to a discrete, stainable disc in either case. Follicle stimulating hormone activity was detected in a narrow segment containing only one disc a few millimeters below growth hormone. Comparison of the mobilities of the hormones from homogenates and secretory granule extracts suggests that they have essentially similar electrophoretic characteristics at basis pH.

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