PROGESTERONE AND HUMAN CHORIONIC GONADOTROPHIN (HCG) LEVELS IN PLASMA DURING DILATION OF THE UTERINE CERVIX IN EARLY HUMAN PREGNANCY

1970 ◽  
Vol 65 (2) ◽  
pp. 293-301 ◽  
Author(s):  
Petter Fylling ◽  
Nils Norman
Keyword(s):  
Plasma Level ◽  
Uterine Cervix ◽  
First Trimester ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Control Group ◽  
Human Pregnancy ◽  
Medial Side ◽  
The Mean ◽  
Early Human

ABSTRACT Dilation of the uterine cervix for 16 hours as a preliminary to the induction of legal abortion during the first trimester of human pregnancy resulted in a marked increase in the plasma level of both progesterone and human chorionic gonadotrophin (HCG). In a control group (with the dilating instrument taped on the medial side of the upper thigh) no increase in progesterone occurred. The increase in the plasma level of HCG was more pronounced than that of progesterone, the mean increase being 80 and 50 per cent respectively. Following the termination of the pregnancy, the half life (t½) of endogenous HCG in peripheral plasma could be calculated, and was found to be about 7 hours.

PROPRANOLOL-BLOCKADE OF VASOPRESSIN INDUCED INCREASE IN PLASMA PROGESTERONE IN EARLY HUMAN PREGNANCY

1971 ◽  
Vol 66 (2) ◽  
pp. 283-288 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Cyclic Amp ◽  
Uterine Cervix ◽  
Adenosine Monophosphate ◽  
First Trimester ◽  
Blocking Agent ◽  
Simultaneous Administration ◽  
Plasma Progesterone ◽  
Human Pregnancy ◽  
Peripheral Plasma ◽  
Early Human

ABSTRACT Following continuous dilation of the uterine cervix or intravenous infusion of vasopressin during the first trimester of human pregnancy, a marked increase in the peripheral plasma progesterone levels was observed. This effect was blocked by simultaneous administration of propranolol (Inderal®), a β-blocking agent. It is suggested that both these stimulating and inhibiting effects might be related to 3′, 5′-adenosine monophosphate (cyclic AMP). The results indicate the existence of β-receptors in steroid producing tissues.

THE ULTRASTRUCTURE OF THE HUMAN GRANULOSAL LUTEIN CELL OF THE FIRST TRIMESTER OF GESTATION

1968 ◽  
Vol 58 (3) ◽  
pp. 481-496 ◽  
Author(s):  
Poul Hjortkjær Pedersen ◽  
Jørgen Falck Larsen
Keyword(s):  
Endoplasmic Reticulum ◽  
Smooth Endoplasmic Reticulum ◽  
First Trimester ◽  
Corpora Lutea ◽  
Steroid Synthesis ◽  
Intracellular Location ◽  
Human Pregnancy ◽  
Subendothelial Space ◽  
Lutein Cell ◽  
Early Human

ABSTRACT The ultrastructure of granulosal lutein cells of 13 corpora lutea in early human pregnancy was studied. The predominant cytoplasmic element was the smooth endoplasmic reticulum. No convincing signs of degeneration of the lutein cells could be demonstrated within the first 14 weeks of pregnancy, as the mitochondria as well as the rough and smooth endoplasmic reticulum were well preserved. However, lysosomes may be slightly more numerous in older specimens and the subendothelial space increases with the age of gestation. A particular type of multilaminated structure one to five micron in diameter was observed, particularly in the earliest specimens. The possible intracellular location of steroid synthesis is discussed.

Is ProBNP a New Marker for Predicting Intrauterine Growth Restriction?

2021 ◽  
Vol 225 (02) ◽  
pp. 125-128
Author(s):  
Hasan Eroğlu ◽  
Nazan Vanlı Tonyalı ◽  
Gokcen Orgul ◽  
Derya Biriken ◽  
Aykan Yucel ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Final Analysis ◽  
First Trimester ◽  
Maternal Serum ◽  
Growth Restriction ◽  
Control Group ◽  
Aneuploidy Screening ◽  
Intrauterine Growth ◽  
Potential Marker ◽  
The Mean

Abstract Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11–14th gestational weeks were centrifuged. The obtained plasma samples were placed in Eppendorf tubes and stored at −80+°C. For the final analysis, first-trimester maternal serum ProBNP levels of 32 women diagnosed with postpartum IUGR and 32 healthy women randomly selected as the control group were compared. FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Results The mean ProBNP levels were statistically and significantly higher in the women with intrauterine growth restriction (113.73±94.69 vs. 58.33±47.70 pg/mL, p<0.01). At a cut-off level of 50.93, ProBNP accurately predicted occurrence of IUGR (AUC+= 0.794 (95% confidence interval 0.679–0.910), p+= 0.001) with sensitivity and specificity rates of 78.1 and 69.0%, respectively. Conclusion First-trimester serum ProBNP level was significantly higher in women who developed IUGR compared to healthy controls. First-trimester ProBNP level can be used as a potential marker to predict the development of IUGR in pregnant women.

The stability of free-β human chorionic gonadotrophin and pregnancy-associated plasma protein-A in first trimester dried blood spots

2011 ◽  
Vol 31 (3) ◽  
pp. 293-298 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Anastasia Stamatopoulou ◽  
Paivi Liitti ◽  
Mikko Suonpaa ◽  
Kevin Spencer
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Dried Blood Spots ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Blood Spots ◽  
The Stability

scholarly journals Down's Syndrome Screening Using Free βhCG: Instability Can Significantly Increase the Down's Risk Estimate

1996 ◽  
Vol 33 (6) ◽  
pp. 525-529 ◽  
Author(s):  
Janine M Beaman ◽  
Naheed Akhtar ◽  
David J Goldie
Keyword(s):  
High Risk ◽  
Risk Classification ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Risk Estimate ◽  
Two Samples ◽  
The Mean ◽  
The Stability ◽  
Sample Separation ◽  
The Impact

The stability of free βhCG (human chorionic gonadotrophin) was assessed using a dual α-fetoprotein and free βhCG assay. A significant increase in free βhCG concentration was observed in heparinized samples left unseparated for 24 h or more, the mean increase in 21 samples being 10.2% after 24 h ( P = < 0.001), increasing to 45.7% after 96 h. Similar results were also obtained in clotted samples. The effect of the increase in free βhCG on the Down's risk estimate was calculated to assess the impact of delayed sample transport and separation. The Down's risk increased in all samples with increasing separation time, but this was most significant in two samples where, using a cut off of one in 250, the risk classification changed from low risk to high risk. These results suggest that delayed sample separation can have a significant effect on screening programmes using free βhCG, particularly with respect to those patients whose risk classification is changed.

Performance of free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands

2009 ◽  
Vol 47 (2) ◽  
Author(s):  
Ingeborg H. Linskens ◽  
Marieke Levitus ◽  
Anneke Frans ◽  
Peter C.J.I. Schielen ◽  
John M.G. van Vugt ◽  
...  
Keyword(s):  
The Netherlands ◽  
Plasma Protein ◽  
Screening Program ◽  
Medical Center ◽  
Protein A ◽  
First Trimester ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Serum Samples ◽  
Β Hcg

Abstract: The VU University Medical Center (VUmc) was the first hospital in the Netherlands to introduce the Delfia Xpress for the analysis of free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester screening program for Down syndrome. Since then, others have implemented this system. In this study, we tested the equality of measurements for free β-hCG and PAPP-A between Delfia Xpress systems and one AutoDelfia system.: A total of 40 serum samples were aliquoted and stored at –20°C. Samples were analyzed by six Delfia Xpress systems and one AutoDelfia system over a time period of 2 years.: The relationships between free β-hCG and PAPP-A were excellent for the different Delfia Xpress systems (r>0.99, p<0.0001). For PAPP-A, the agreement between the main system at VUmc and five other systems was linear with slopes between 0.99 and 1.06. Similarly, agreement for free β-hCG was linear with slopes between 0.99 and 1.09. Likewise, agreement for PAPP-A and free β-hCG was excellent for the AutoDelfia vs. the main Delfia Xpress at the VUmc (r>0.99, p<0.0001). For both PAPP-A and free β-hCG, the relationships were linear with slopes of 1.08 and 1.07.: We demonstrate an excellent agreement for the analysis of PAPP-A and free β-hCG between Delfia Xpress systems and one AutoDelfia system.Clin Chem Lab Med 2009;47:222–6.

Sign in / Sign up

Export Citation Format

Share Document