HEMOGLOBIN F IN NEWBORN INFANTS OF DIABETIC MOTHERS

1974 ◽  
Vol 77 (3_Suppl) ◽  
pp. S73-S80 ◽  
Author(s):  
Otto Davidsen
Keyword(s):  
Gestational Age ◽  
Relative Concentration ◽  
Newborn Infants ◽  
Maternal Diabetes ◽  
Agar Gel ◽  
Diabetes Group ◽  
Hemoglobin F ◽  
Infants Of Diabetic Mothers ◽  
Agar Gel Electrophoresis ◽  
Diabetic Mothers

ABSTRACT The relative concentration of hemoglobin F was determined by use of agar gel electrophoresis in the cord blood from 38 infants of diabetic mothers and 94 infants with non-diabetic mothers. The relative concentration of hemoglobin F was found to be negatively correlated to the gestational age of the infants. In infants of diabetic mothers the concentration was insignificantly higher than would be expected from their gestational age, and comparable to that of infants of non-diabetic mothers of about 2 weeks lower gestational age. In the diabetes group hemoglobin F was correlated neither to the increased birth weight of the infants nor to the severity of the maternal diabetes.

ALPHA1-FETOPROTEIN AND CARBONIC ANHYDRASE B AND C CONCENTRATION IN CORD BLOOD FROM NEWBORN INFANTS OF DIABETIC MOTHERS

1974 ◽  
Vol 77 (3_Suppl) ◽  
pp. S81-S86 ◽  
Author(s):  
B. Nørgaard-Pedersen ◽  
J. G. Klebe
Keyword(s):  
Carbonic Anhydrase ◽  
Cord Blood ◽  
Gestational Age ◽  
Newborn Infants ◽  
Infants Of Diabetic Mothers ◽  
Carbonic Anhydrase B ◽  
Erythrocyte Carbonic Anhydrase ◽  
Diabetic Mothers

ABSTRACT Erythrocyte carbonic anhydrase (CA) concentration B and C and the α1-fetoprotein (AFP) concentration was determined in cord blood from 45 newborn infants of diabetic mothers (IDM). The concentration of these quantities has separately been compared with the corresponding concentration in cord blood from normal newborn infants with the same gestational age. No difference was found except for AFP, where a significantly (P < 0.05) higher concentration was found in some infants of insulin treated diabetic mothers.

scholarly journals Biochemical and Physiological Characteristics of Neonates Born to Mothers with Diabetes During Gestation

2012 ◽  
Vol 31 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Ljubomir Milašinović ◽  
Ivan Hrabovski ◽  
Zorica Grujić ◽  
Mirjana Bogavac ◽  
Aleksandra Nikolić
Keyword(s):  
Birth Weight ◽  
Glucose Homeostasis ◽  
Gestational Age ◽  
Newborn Infants ◽  
Physiological Characteristics ◽  
Control Group ◽  
High Birth Weight ◽  
Infants Of Diabetic Mothers ◽  
Group I ◽  
Diabetic Mothers

Biochemical and Physiological Characteristics of Neonates Born to Mothers with Diabetes During GestationThe aim of this study was to investigate how glucose homeostasis disorders influence biochemical homeostasis and fetal maturation. A prospective randomized study included 102 infants: 31 newborns of mothers with glucose homeostasis disorders (Group I) and 71 newborns of healthy mothers (Group II). In the pregnant women, the mean age, body weight and height, BMI, parity, duration of the disease and the mode of labor were estimated. The following procedures were performed in each newborn infant: physical examination, determination of Apgar score, measurements of birth weight and length, estimation of neurological status, clinical estimation of gestational age, ECG and ultrasonography of the brain, as well as the basic hematologic, biochemical and microbiological analyses. Newborn infants of diabetic pregnancies were small for gestational age and of high birth weight. The levels of Na+, K+and Cl-ions did not show significant differences between the investigated groups, whereas the levels of total Ca and Mg were significantly decreased (2.18±0.59 and 0.65±0.17 mmol/L) (p<0.001) in the investigated group relative to the control group (2.42±0.53 and 0.81±0.09 mmol/L). The newborn infants of diabetic pregnancies presented with significantly decreased values of phosphates, bicarbonates and pH, whereas the difference in total osmolality was not statistically significant. The level of glucose at birth in the infants of diabetic mothers was lower (2.91±0.51 mmol/L) (p<0.001) than in the infants of healthy pregnancies (3.94±0.29 mmol/L). Glycemia lower than 2 mmol/L was recorded in 6.5% of infants of the investigated group. The level of bilirubin was significantly increased (209.71±56.66 mmol/L) (p<0.001) in infants of diabetic mothers compared to those of the healthy ones (155.70±61.14 mmol/L), like the incidence of clinically manifested hyperbilirubinemia. Disorders of maternal glucose homeostasis cause biochemical disorders such as hypoglycemia, hypocalcemia, hyperbilirubinemia, hypomagne semia and are associated with impaired maturation and congenital malformations of the fetus.

A CONTROLLED CLINICAL TRIAL OF THE EFFECTS OF WATER VAPOR MIST ON RESPIRATORY DISTRESS AMONG INFANTS OF DIABETIC MOTHERS

PEDIATRICS ◽  
1957 ◽  
Vol 20 (2) ◽  
pp. 234-240
Author(s):  
David Yi-Yung Hsia ◽  
Herbert G. Peterson ◽  
Sydney S. Gellis
Keyword(s):  
Clinical Trial ◽  
Water Vapor ◽  
Respiratory Distress ◽  
Clinical Evidence ◽  
Newborn Infants ◽  
Maternal Diabetes ◽  
Striking Difference ◽  
Controlled Clinical Trial ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

A controlled clinical trial of the effects of water vapor mist on respiratory distress has been undertaken in a group of 100 newborn infants of diabetic mothers. Half of the group was placed in an incubator in which the atmosphere was supersaturated with water vapor mist (over 100% humidity). The other half was placed in a similar incubator with 50 to 70% humidity. The infants in the two groups were comparable with respect to sex, weight, severity of maternal diabetes, etc. The two groups were compared with regard to mortality, clinical evidence of respiratory distress, respiratory rates, and roentgenographic evidence of pulmonary hyaline membranes. No striking difference could be found in the course and outcome of the infants in the two groups.

Hemopexin in newborn infants of diabetic mothers

1968 ◽  
Vol 46 (3) ◽  
pp. 417-420 ◽  
Author(s):  
O. V. Sirek ◽  
A. Sirek ◽  
A. Bucalossi
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Serum Proteins ◽  
Elevated Serum ◽  
Newborn Infants ◽  
Infants Of Diabetic Mothers ◽  
Serum Glycoprotein ◽  
Normal Women ◽  
Positive Line ◽  
Diabetic Mothers

Serum proteins from cord blood of 27 infants of diabetic and 16 infants of normal women of comparable gestational age (38–39 weeks) were studied by immunoelectrophoresis. In accord with our previous finding of elevated serum glycoprotein levels in newborn infants of diabetic mothers, a well-defined precipitation arc in the beta-one globulin region, inside the concavity of the transferrin arc, was identified in these infants as hemopexin, because it (a) stained intensively for carbohydrate, (b) did not bind hemoglobin but did bind hemin, and (c) formed a single benzidine-positive line with anti-hemopexin serum.

Leptin Concentrations Are Elevated in Newborn Infants of Diabetic Mothers

2001 ◽  
Vol 55 (4) ◽  
pp. 185-190 ◽  
Author(s):  
Päivi Tapanainen ◽  
Erja Leinonen ◽  
Aimo Ruokonen ◽  
Mikael Knip
Keyword(s):  
Newborn Infants ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Water and Electrolyte Economy in Newborn Infants of Diabetic Mothers

1960 ◽  
Vol 49 (2) ◽  
pp. 121-128 ◽  
Author(s):  
CHARLES D. COOK ◽  
DONOUGH O'BRIEN ◽  
JOHN D. L. HANSEN ◽  
MARC BEEM ◽  
CLEMENT A. SMITH
Keyword(s):  
Newborn Infants ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Body Composition of Newborn Infants of Diabetic Mothers, Mogens Osler, Copenhagen F, Denmark, Osler, 1961, 79 pp

PEDIATRICS ◽  
1962 ◽  
Vol 29 (5) ◽  
pp. 728-728
Author(s):  
Marvin Cornblath
Keyword(s):  
Body Composition ◽  
Urinary Excretion ◽  
Newborn Infants ◽  
Body Water ◽  
Review Of The Literature ◽  
Infants Of Diabetic Mothers ◽  
Proper Length ◽  
Diabetic Mothers

Dr. Osler, in his monograph, merely reiterates and summarizes work he has done in studying the height, weight, urinary excretion, and compartmental body water in babies of diabetic mothers. In the monograph, he presents the data in a fashion that makes it impossible to analyze and has added nothing new except that the diabetic baby is the proper length for its weight. In addition, he has made a sketchy, uncritical review of the literature pertaining to these babies and presents the data, again, in a summary fashion.

Relative Rates of Fetal Hemoglobin and Adult Hemoglobin Synthesis in Cord Blood of Infants of Insulin-Dependent Diabetic Mothers

PEDIATRICS ◽  
1985 ◽  
Vol 75 (6) ◽  
pp. 1143-1147 ◽  
Author(s):  
Harry Bard ◽  
Janie Prosmanne
Keyword(s):  
Newborn Infants ◽  
Methyl Cellulose ◽  
Fetal Hemoglobin ◽  
Acid Mixture ◽  
Hemoglobin Synthesis ◽  
Infants Of Diabetic Mothers ◽  
Insulin Dependent ◽  
Adult Hemoglobin ◽  
Insulin Dependent Diabetic ◽  
Diabetic Mothers

Erythrocytosis, extramedullary erythropoiesis, and increased levels of plasma erythropoietin have been observed in newborn infants of diabetic mothers. Because there is evidence that there is a relationship between increased fetal hemoglobin production and acute erythropoietic expansion, it was considered important to study the proportion of fetal hemoglobin and adult hemoglobin synthesis in newborn infants of insulin-dependent diabetic mothers. Samples from nine newborn infants of diabetic mothers as well as nine control infants, ranging from 36 to 38 weeks of gestation, were incubated in an amino acid mixture containing [14C]leucine. The adult hemoglobin and fetal hemoglobin were then separated by column chromatography on DEAE [O-(diethylaminoethyl)] Sephadex. To confirm that the fetal hemoglobin obtained after Sephadex chromatography was not contaminated with other hemoglobins, several of the DEAE separations from each group were reconstituted and subjected to polypeptide chain elution using carboxyl-methyl cellulose chromatography. The data demonstrated that the newborn infants of diabetic mothers are synthesizing significantly more fetal hemoglobin than is expected for their period of development (82.2 ± 3.6 v 72.8 ± 4.2; P &lt; .005). It is suggested that the in utero environment of the fetus of the diabetic mother causes an increase in fetal hemoglobin synthesis.

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