"STEROID-CELL" ANTIBODY IN ENDOCRINE DISEASES

ABSTRACT By means of an indirect immunofluorescence technique, sera from 116 patients with Addison's disease, an equal number of age and sex matched controls and 97 patients with other endocrine diseases were examined for the occurrence of antibody to steroid-producing cells in ovary, testis and adrenal cortex. Fluorescent staining was observed in the theca cells of growing follicles, the theca lutein cells, testicular Leydig cells and adrenal cortical cells, i. e. cells which contain enzyme systems used in steroid hormone production. The "steroid-cell" antibody was present in 24 % of the patients with idiopathic Addison's disease, equally frequent in males and females, and in 17 % of the patients with tuberculous Addison's disease, but was rarely found in controls, including patients with other endocrine diseases. Female hypergonadotrophic hypogonadism made an exception, since the "steroid-cell" antibody was found in about half the cases with this condition.

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Addison's Disease Revisited in Poland: Year 2008 versus Year 1990

Autoimmune Diseases ◽

10.4061/2010/731834 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Anna A. Kasperlik-Zaluska ◽

Barbara Czarnocka ◽

Wojciech Jeske ◽

Lucyna Papierska

Keyword(s):

Computed Tomography ◽

Addison’S Disease ◽

Addison's Disease ◽

Immunofluorescence Technique ◽

Imaging Studies ◽

Immunofluorescence Method ◽

Modern Technique ◽

Indirect Immunofluorescence Technique ◽

Group A ◽

Group B

This study aimed at comparing two groups of patients with Addison's disease: A, including 180 patients described in 1991 and B, consisting of 138 patients registered since 1991. The incidence of coexisting autoimmune disorders was evaluated and etiological factors were analyzed. Immunological and imaging studies (computed tomography in group B) were performed. Adrenal autoantibodies were examined by an indirect immunofluorescence technique in group A, and by the assay measuring autoantibodies against steroid 21-hydroxylase in group B. Adrenal autoantibodies were revealed in 37% of patients examined by the immunofluorescence method and in 63% investigated by the modern technique. Tuberculosis was found in 52 patients in the group A and in two patients in the group B; metastatic infiltrations of the adrenals in CT were detected in 16 patients. Probable autoimmune Addison's disease was diagnosed in 125/180 patients (69%) in the group A and in 116/138 patients (84%) in the group B.

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Problems in Diagnosis of Addison’s Disease and its Misdiagnosis as Chronic Kidney Disease (CKD): A Case Report

Nephro-Urology Monthly ◽

10.5812/numonthly.110056 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Tahereh Sabaghian ◽

Minoo Heidari Almasi

Keyword(s):

Chronic Kidney Disease ◽

Renal Failure ◽

Kidney Disease ◽

Addison’S Disease ◽

Primary Diagnosis ◽

Adrenal Crisis ◽

Addison's Disease ◽

Adrenal Failure ◽

Case Presentation ◽

Endocrine Diseases

Introduction: Chronic kidney disease (CKD) rarely occurs at the same time as endocrine diseases such as adrenal failure. There are some reports of cases with acute kidney failure accompanied by Addison’s disease and adrenal crisis. The studied case was a patient with Addison’s disease referring with manifestations of AKI on CKD and hyperkalemia without hypotension. Case Presentation: This report describes a 34-year-old man with the primary diagnosis of CKD and the subsequent diagnosis of Addison’s disease. Conclusions: Since renal failure is accompanied by hyperkalemia, the diagnosis of adrenal failure will be difficult in the case of no obvious hyponatremia and hypotension. Thus, it is necessary to carefully check the clinical and laboratory symptoms and high clinical suspicions in CKD patients.

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MECHANISMS IN ENDOCRINOLOGY: Vitamin D as a potential contributor in endocrine health and disease

Acta Endocrinologica ◽

10.1530/eje-14-0158 ◽

2014 ◽

Vol 171 (3) ◽

pp. R101-R110 ◽

Cited By ~ 73

Author(s):

Giovanna Muscogiuri ◽

Joanna Mitri ◽

Chantal Mathieu ◽

Klaus Badenhoop ◽

Gonca Tamer ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary ◽

Addison’S Disease ◽

Vitamin D Supplementation ◽

Current Evidence ◽

Addison's Disease ◽

Endocrine Disease ◽

Autoimmune Thyroid ◽

Endocrine Diseases

ObjectiveIt has been suggested that vitamin D may play a role in the pathogenesis of several endocrine diseases, such as hyperparathyroidism, type 1 diabetes (T1DM), type 2 diabetes (T2DM), autoimmune thyroid diseases, Addison's disease and polycystic ovary syndrome (PCOS). In this review, we debate the role of vitamin D in the pathogenesis of endocrine diseases.MethodsNarrative overview of the literature synthesizing the current evidence retrieved from searches of computerized databases, hand searches and authoritative texts.ResultsEvidence from basic science supports a role for vitamin D in many endocrine conditions. In humans, inverse relationships have been reported not only between blood 25-hydroxyvitamin D and parathyroid hormone concentrations but also with risk of T1DM, T2DM, and PCOS. There is less evidence for an association with Addison's disease or autoimmune thyroid disease. Vitamin D supplementation may have a role for prevention of T2DM, but the available evidence is not consistent.ConclusionsAlthough observational studies support a potential role of vitamin D in endocrine disease, high quality evidence from clinical trials does not exist to establish a place for vitamin D supplementation in optimizing endocrine health. Ongoing randomized controlled trials are expected to provide insights into the efficacy and safety of vitamin D in the management of endocrine disease.

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Class II MHC expression in normal adrenal cortex and cortical cells in autoimmune Addison's disease

The Journal of Pathology ◽

10.1002/path.1711550207 ◽

1988 ◽

Vol 155 (2) ◽

pp. 113-120 ◽

Cited By ~ 30

Author(s):

Robert Jackson ◽

Anne Marie McNicol ◽

Maura Farquharson ◽

Alan K. Foulis

Keyword(s):

Adrenal Cortex ◽

Addison’S Disease ◽

Class Ii ◽

Addison's Disease ◽

Cortical Cells ◽

Class Ii Mhc

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Ultrastructural Cytopiasmic Changes of Adrenal Cortex During Pregnancy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063408 ◽

1969 ◽

Vol 27 ◽

pp. 298-299

Author(s):

T. M. Murad ◽

Karen Israel ◽

Jack C. Geer

Keyword(s):

Adrenal Gland ◽

Steroid Hormones ◽

Adrenal Cortex ◽

Lipid Droplets ◽

Plasma Cholesterol ◽

Adrenal Steroids ◽

Dynamic Changes ◽

Cortical Cells ◽

Acetyl Coenzyme A ◽

Adrenal Cortical Cells

Adrenal steroids are normally synthesized from acetyl coenzyme A via cholesterol. Cholesterol is also shown to enter the adrenal gland and to be localized in the lipid droplets of the adrenal cortical cells. Both pregnenolone and progesterone act as intermediates in the conversion of cholesterol into steroid hormones. During pregnancy an increased level of plasma cholesterol is known to be associated with an increase of the adrenal corticoid and progesterone. The present study is designed to demonstrate whether the adrenal cortical cells show any dynamic changes during pregnancy.

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