THE HYPERCALCAEMIC SYNDROME IN RATS BEARING THE WALKER CARCINOSARCOMA 256

1975 ◽  
Vol 78 (3) ◽  
pp. 613-624 ◽  
Author(s):  
H. Minne ◽  
F. Raue ◽  
S. Bellwinkel ◽  
R. Ziegler
Keyword(s):  
Soft Tissue ◽  
Animal Models ◽  
Long Range ◽  
Calcium Metabolism ◽  
Phosphorus Excretion ◽  
Tumour Bearing ◽  
Bone Calcium ◽  
Calcium And Phosphorus

ABSTRACT The strain of Walker carcinosarcoma 256 described induces hypercalcaemia, hyperphosphataemia and hyperuraemia in tumour bearing rats. Changes in calcium and phosphorus excretion are observed as well as accompanying calcification of soft tissue organs and loss of bone calcium. These changes in calcium metabolism disappear after removal of the tumour, so that long-range action of the tumour can be stated. The results are discussed in comparison with three other animal models of tumour dependent hypercalcaemia.

Description of a Simple Model for the Study of Bone Calcium Metabolism

1980 ◽  
Vol 19 (01) ◽  
pp. 11-15
Author(s):  
G. Roncari ◽  
L. Rapisardi ◽  
L. Conte ◽  
G. Pedroli
Keyword(s):  
Simple Model ◽  
Calcium Metabolism ◽  
Good Description ◽  
Radioactive Tracer ◽  
Normal Subjects ◽  
Bone Diseases ◽  
Compartment System ◽  
Bone Calcium ◽  
Finite Period ◽  
Kinetics Of

A simple model for the study of bone calcium metabolism is proposed. It describes the kinetics of a radioactive tracer in terms of an open single compartment system with an expanding volume for a finite period of time. In addition to the simplicity of the hypotheses introduced, the model is able to give a good description of the biological processes which regulate calcium kinetics. Moreover the functional parameters can be easily calculated, even just graphically. 15 normal subjects and 22 patients affected by various bone diseases were studied. The results were compared with those obtained by using the model proposed by Burkinshaw et al. and the method described by Reeve et al.

Features of phosphorus-calcium metabolism in children with neurogenic disorders of urination

2020 ◽  
Vol 24 (1) ◽  
pp. 45-50
Author(s):  
Yu. F. Lobanov ◽  
D. Y. Latyshev ◽  
Ya. F. Zverev ◽  
N. A. Tekuteva ◽  
N. M. Mikheeva
Keyword(s):  
Connective Tissue ◽  
Calcium Metabolism ◽  
Point System ◽  
Industry Standards ◽  
Muscular Dysfunction ◽  
Connective Tissue Dysplasia ◽  
Calcium And Phosphorus ◽  
Comparison Of The Results ◽  
Neurogenic Disorders

THE AIM: To study the characteristics of phosphorus-calcium metabolism in patients with neurogenic disorders of urination, taking into account the severity of the manifestations of connective tissue dysplasia. PATIENTS AND METHODS. The study included 90 children, including 60 children with neuro-muscular dysfunction of the bladder (NMDB) and 30 children with enuresis from the age of 5 to 15 years. The diagnosis was established based on a comprehensive examination and according to industry standards. Connective tissue dysplasia was diagnosed in children with the detection of 6 or more small external or visceral manifestations involving 3 or more organs from different systems. Assessment of the severity (severity) of connective tissue dysplasia was carried out according to the point system proposed by T.I. Kadurina et al. Each group was divided into subgroups depending on the severity of the manifestations of connective tissue dysplasia. The determination of the level of calcium and phosphorus in the blood and urine, as well as the calculation of the calcium-creatinine coefficient followed by a comparison of the results in these groups and subgroups. To assess the significance of differences, the Mann-Whitney test was calculated, p <0.05 was considered significant. RESULTS. he level of calcium and phosphorus in the urine was slightly higher in children with enuresis, especially in the morning portion of urine, where the concentration of calcium was 26% higher than in patients with NMDB. At the same time, the value of calcium /creatinine coefficient was significantly higher in the group of patients with enuresis and was 2 times higher than the normative indicators, which indicates the importance of hypercalciuria in the development of enuresis. СONCLUSION. According to the obtained data, the severity of calciuria, determined by the value of the calcium-creatinine coefficient, is significantly higher in patients with enuresis than with NMDB.

Partition of Calcium and Phosphorus Excretion in the Laying Hen

Nature ◽  
1961 ◽  
Vol 189 (4766) ◽  
pp. 759-760 ◽  
Author(s):  
S. HURWITZ ◽  
P. GRIMINGER
Keyword(s):  
Laying Hen ◽  
Phosphorus Excretion ◽  
Calcium And Phosphorus

scholarly journals Identification of a Novel Bone/Calcium Metabolism-regulating Factor in Porcine Pancreas

1996 ◽  
Vol 271 (38) ◽  
pp. 23230-23234 ◽  
Author(s):  
Elzbieta Izbicka ◽  
Toshiyuki Yoneda ◽  
Yoshito Takaoka ◽  
Diane Horn ◽  
Paul Williams ◽  
...  
Keyword(s):  
Calcium Metabolism ◽  
Porcine Pancreas ◽  
Bone Calcium

Calcium Metabolism in Great Dane Dogs Fed Diets with Various Calcium and Phosphorus Levels

1991 ◽  
Vol 121 (suppl_11) ◽  
pp. S99-S106 ◽  
Author(s):  
Herman A. W. Hazewinkel ◽  
Walter E. Van Den Brom ◽  
Arie Th. Van 'T Klooster ◽  
George Voorhout ◽  
Ank Van Wees
Keyword(s):  
Calcium Metabolism ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels ◽  
Great Dane

The metabolism of phosphorus and calcium in sheep during intravenous infusion of phosphorus

1982 ◽  
Vol 33 (5) ◽  
pp. 827 ◽  
Author(s):  
KM Schneider ◽  
RC Boston ◽  
DD Leaver
Keyword(s):  
Soft Tissue ◽  
Control Period ◽  
Compartmental Analysis ◽  
Phosphorus Concentration ◽  
Hormonal Changes ◽  
Deconvolution Analysis ◽  
Tracer Techniques ◽  
Calcium And Phosphorus ◽  
The Difference ◽  
Tissue Accretion

The metabolism of calcium and phosphorus in mature sheep, given firstly a chaff diet and then chaff with an intravenous supplement of 1.5-2.0 g/day of phosphorus, was studied by using tracer techniques and compartmental analysis. Absorption was also studied by deconvolution analysis and a technique relating the excretion of tracer in faeces to that of an insoluble marker. Under the conditions of the experiment most of the additional phosphorus infused intravenously was excreted in the faeces, and this was due to a concurrent increase in the endogenous secretion and a decrease in the efficiency of absorption of phosphorus. In sheep given 2.0 g of phosphorus per day, the phosphorus concentration in plasma increased 2.5-4 times, but the excretion of phosphorus in the urine remained small (less than 0.3 g/day) compared with the excretion of 2.5 g/day of phosphorus in the faeces. One feature of the experiment was the difference in the behaviour of bone and soft tissue reservoirs between the sheep given 1.5 g/day of phosphorus and those given 2.0 g/day. In the former group accretion and resorption of calcium and phosphorus in bone and soft tissue increased when compared with the control period, whereas in the latter group bone and soft tissue accretion of phosphorus was unchanged and resorption increased slightly. These results are discussed in terms of the hormonal changes that occur following changes in plasma calcium and phosphorus.

Biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3

1983 ◽  
Vol 244 (2) ◽  
pp. E159-E163
Author(s):  
S. Okamoto ◽  
Y. Tanaka ◽  
H. F. DeLuca ◽  
Y. Kobayashi ◽  
N. Ikekawa
Keyword(s):  
Biological Activity ◽  
Calcium Transport ◽  
Plasma Calcium ◽  
Epiphyseal Plate ◽  
Dihydroxyvitamin D3 ◽  
Responsive Systems ◽  
1,25 Dihydroxyvitamin D3 ◽  
Bone Calcium ◽  
Calcium And Phosphorus

The biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 was compared with 1,25-dihydroxyvitamin D3 in the rat. The 24,24-difluoro-1,25-dihydroxyvitamin D3 has a potency of approximately 5-10 times that of 1,25-dihydroxyvitamin D3 in the known in vivo vitamin D responsive systems. These systems include intestinal calcium transport, bone calcium mobilization, calcification of epiphyseal plate cartilage, and elevation of plasma calcium and phosphorus concentrations. Thus, 24,24-difluoro-1,25-dihydroxyvitamin D3 is the first known analogue with higher potency than 1,25-dihydroxyvitamin D3 in vivo.

scholarly journals Insulin-Like Growth Factor I and Growth Hormone (GH) Treatment in GH-Deficient Humans: Differential Effects on Protein, Glucose, Lipid, and Calcium Metabolism1

2000 ◽  
Vol 85 (4) ◽  
pp. 1686-1694 ◽  
Author(s):  
Nelly Mauras ◽  
Kimberly O. O’Brien ◽  
Susan Welch ◽  
Annie Rini ◽  
Kevin Helgeson ◽  
...  
Keyword(s):  
Growth Factor ◽  
Muscle Strength ◽  
Fat Mass ◽  
Calcium Metabolism ◽  
Insulin Like Growth Factor ◽  
Oxidation Rates ◽  
Factor I ◽  
Bone Calcium ◽  
Growth Factor I ◽  
Glucose Output

We examined the effects of recombinant human (rh) insulin-like growth factor I (IGF-I) vs. rhGH in a variety of metabolic paths in a group of eight severely GH-deficient young adults using an array of contemporary tools. Protein, glucose, and calcium metabolism were studied using stable labeled tracer infusions of l-[1-13C]leucine,[ 6,6-2H2]glucose, and 42Ca and 44Ca; substrate oxidation rates were assessed using indirect calorimetry; muscle strength was determined by isokinetic and isometric dynamometry of the anterior quadriceps, as well as growth factors, hormones, glucose, and lipid concentrations in plasma before and after 8 weeks of rhIGF-I (60 μg/kg, sc, twice daily), followed by 4 weeks of washout, then 8 weeks of rhGH (12.5 μg/kg·day, sc); the treatment order was randomized. In the doses administered, rhIGF-I and rhGH both increased fat-free mass and decreased the percent fat mass, with a more robust decrease in the percent fat mass after rhGH; both were associated with an increase in whole body protein synthesis rates and a decrease in protein oxidation. Neither hormone affected isokinetic or isometric measures of skeletal muscle strength. However, rhGH was more potent than rhIGF-I at increasing lipid oxidation rates and improving plasma lipid profiles. Both hormones increased hepatic glucose output, but rhGH treatment was also associated with decreased carbohydrate oxidation and increased glucose and insulin concentrations, indicating subtle insulin resistance. Neither hormone significantly affected bone calcium fluxes, supporting the concept that these hormones, by themselves, are not pivotal in bone calcium metabolism. In conclusion, rhIGF-I and rhGH share common effects on protein, muscle, and calcium metabolism, yet have divergent effects on lipid and carbohydrate metabolism in the GH-deficient state. These differences may allow for better selection of treatment modalities depending on the choice of desired effects in hypopituitarism.

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