FREE CORTISOL IN OBESITY; EFFECT OF FASTING

1976 ◽  
Vol 81 (2) ◽  
pp. 321-329 ◽  
Author(s):  
A. Galvão-Teles ◽  
Linda Graves ◽  
C. W. Burke ◽  
K. Fotherby ◽  
Russell Fraser
Keyword(s):  
Protein Intake ◽  
Urinary Free Cortisol ◽  
Significant Rise ◽  
Low Protein ◽  
Free Cortisol ◽  
Before And After ◽  
Obese Subjects ◽  
Cortisol Excretion ◽  
Cortisol Levels ◽  
Protein Diets

ABSTRACT Plasma and urinary corticosteroids were measured in 13 obese subjects before and after high and low protein diets, and after fasting. During isocaloric high and low protein diets, urinary 17-oxogenic steroids and to a lesser extent urinary free cortisol excretion rose and fell in parallel with protein intake. Plasma unbound cortisol levels were not much changed by high or low protein intake. However, during 7 to 11 days total fasting, there was a highly significant rise in plasma unbound cortisol at 24.00. A smaller rise occurred at 09.00. The overall effect was a considerable diminution of the day-night variation of plasma unbound cortisol levels during fasting, and a rise in prevailing unbound cortisol levels and urinary free cortisol excretion. In 3 subjects tested these changes were reversed immediately by glucose re-feeding.

Relationship between 24-hour urinary-free cortisol excretion and salivary cortisol levels sampled from awakening to bedtime in healthy subjects

Life Sciences ◽  
2003 ◽  
Vol 73 (3) ◽  
pp. 349-358 ◽  
Author(s):  
Rachel Yehuda ◽  
Sarah L. Halligan ◽  
Ren Kui Yang ◽  
Ling Song Guo ◽  
Iouri Makotkine ◽  
...  
Keyword(s):  
Salivary Cortisol ◽  
Healthy Subjects ◽  
Urinary Free Cortisol ◽  
Free Cortisol ◽  
Cortisol Excretion ◽  
Cortisol Levels

Clinical evaluation of the liquid-chromatographic determination of urinary free cortisol.

1983 ◽  
Vol 29 (5) ◽  
pp. 847-851 ◽  
Author(s):  
J Nakamura ◽  
M Yakata
Keyword(s):  
Normal Subjects ◽  
Chromatographic Determination ◽  
Urinary Free Cortisol ◽  
Urinary Cortisol ◽  
Liquid Chromatographic Method ◽  
Free Cortisol ◽  
Urinary Cortisol Excretion ◽  
Liquid Chromatographic Determination ◽  
Cortisol Excretion ◽  
Liquid Chromatographic

Abstract We recently reported (Clin. Chem. 28: 1497-1500, 1982) a liquid-chromatographic method for quantifying free cortisol in urine. We have since evaluated the clinical utility of our method by assaying cortisol in urine from normal subjects, patients, and subjects undergoing endocrine tests. We found that, in contrast with plasma cortisol, urinary cortisol is not bound to protein. It shows some correlation with 17-hydroxycorticosteroids in urine, but is independent of creatinine excretion. The amount of cortisol excreted daily by a particular individual was found to be fairly constant during nine or 10 days. Normal values determined for 203 apparently healthy individuals were 35.8 (SD 18.7) micrograms/day, with no significant sex-related differences but a tendency for a gradual decrease of cortisol excretion with age. We also report urinary cortisol excretion by patients with pituitary-adrenal disorders and some other diseases, and the pattern of response to dexamethasone and metyrapone administration.

URINARY FREE CORTISOL EXCRETION PATTERN IN MORBID OBESE WOMEN

2001 ◽  
Vol 27 (1-2) ◽  
pp. 261-268 ◽  
Author(s):  
R. Vilà ◽  
M. L. Granada ◽  
R. M. Gutiérrez ◽  
J. A. Fernández-López ◽  
X. Remesar ◽  
...  
Keyword(s):  
Urinary Free Cortisol ◽  
Obese Women ◽  
Excretion Pattern ◽  
Free Cortisol ◽  
Morbid Obese ◽  
Cortisol Excretion

Urinary free cortisol levels in obsessive-compulsive disorder

1990 ◽  
Vol 32 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Timothy L. Gehris ◽  
Roger G. Kathol ◽  
Donald W. Black ◽  
Russell Noyes
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Urinary Free Cortisol ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Free Cortisol ◽  
Cortisol Levels

scholarly journals Decreased pituitary sensitivity to glucocorticoids in endurance-trained men

2001 ◽  
pp. 363-368 ◽  
Author(s):  
M Duclos ◽  
JB Corcuff ◽  
F Pehourcq ◽  
A Tabarin
Keyword(s):  
Hpa Axis ◽  
Low Dose ◽  
Urinary Free Cortisol ◽  
Test Results ◽  
O2 Uptake ◽  
Plasma Acth ◽  
Free Cortisol ◽  
Suppression Test ◽  
Cortisol Levels ◽  
Dexamethasone Suppression

OBJECTIVE: Muscular exercise induces hypothalamo-pituitary-adrenal (HPA) axis activation and when regularly repeated, as in endurance training, leads to HPA axis adaptation. To assess whether non-professional endurance-trained (ET) men with a substantial training load and no clinical or biological features of HPA axis overactivity can present subtle alterations of HPA axis sensitivity to glucocorticoid negative feedback, nine ET men were subjected to HPA axis testing using the dexamethasone-corticotrophin-releasing hormone (CRH) test. DESIGN: Nine endurance-trained men and eight healthy age-matched sedentary men were studied. Morning plasma cortisol and 24 h urinary free cortisol (UFC) were determined and a low dose dexamethasone suppression test (LDDST) was performed followed by CRH stimulation (dexamethasone-CRH test). RESULTS: After a day without physical exercise, at 0800 h, plasma ACTH and cortisol concentrations, and the 24 h UFC and UFC/urinary creatinine (UC) ratio were similar in ET and sedentary men. By contrast, clear differences between the groups were seen in cortisol and ACTH responses to the dexamethasone-CRH test. In eight ET subjects, after LDDST, basal ACTH and cortisol levels were similar to those of sedentary men, whereas one ET subject displayed a poor suppression of cortisol level (131 nmol/l). After injection of CRH, however, three of nine ET men's cortisol levels were not suppressed by dexamethasone but instead displayed significant CRH-induced increase (peak cortisol: 88, 125 and 362 nmol/l). No sedentary subject exhibited any increase in cortisol levels. CONCLUSION: Three of nine ET men with a mean maximum rate of O2 uptake (VO2, max) of 61 ml/kg per min, running 50-70 km per week, were resistant to glucocorticoid suppression during the combined dexamethasone-CRH test.

The relationship between 63 days of 24-h urinary free cortisol and hair cortisol levels in 10 healthy individuals

2016 ◽  
Vol 73 ◽  
pp. 142-147 ◽  
Author(s):  
S.L. van Ockenburg ◽  
H.M. Schenk ◽  
A. van der Veen ◽  
E.F.C. van Rossum ◽  
I.P. Kema ◽  
...  
Keyword(s):  
Urinary Free Cortisol ◽  
Hair Cortisol ◽  
Healthy Individuals ◽  
Free Cortisol ◽  
Cortisol Levels ◽  
The Relationship
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