Role of Wnt antagonists (sclerostin and Dkk-1) on bone turnover markers and bone mass, in patients with complete spinal cord injury: preliminary results

2013 ◽  
Author(s):  
Laia Gifre ◽  
Joan Vidal ◽  
Silvia Ruiz-Gaspa ◽  
Enric Portell ◽  
Ana Monegal ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Preliminary Results ◽  
Cord Injury ◽  
Turnover Markers ◽  
Complete Spinal Cord Injury

AB0614 Role of wnt antagonists (sclerostin and dkk-1) on bone turnover markers and bone mass, in patients with complete spinal cord injury. preliminary results

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A977.2-A977
Author(s):  
L. Gifre ◽  
J. Vidal ◽  
S. Ruiz-Gaspà ◽  
E. Portell ◽  
A. Monegal ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Preliminary Results ◽  
Cord Injury ◽  
Turnover Markers ◽  
Complete Spinal Cord Injury

Bone turnover markers in patients with chronic spinal cord injury and heterotopic ossification

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S171-S172
Author(s):  
M.A. Bystrytska⁎ ◽  
V.V. Povoroznyuk
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Turnover ◽  
Heterotopic Ossification ◽  
Bone Turnover Markers ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury ◽  
Turnover Markers

scholarly journals Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

2020 ◽  
Vol 14 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Prince Thakkar ◽  
Naveen B. Prakash ◽  
George Tharion ◽  
Sahana Shetty ◽  
Thomas V. Paul ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Loss ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
Turnover Markers

scholarly journals BONE MINERAL STATUS AND METABOLISM DISORDERS IN PATIENTS WITH CHRONIC SPINAL CORD INJURY

2018 ◽  
Author(s):  
M. A. Bystrytska
Keyword(s):  
Spinal Cord ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Peak Bone Mass ◽  
Mineral Status ◽  
Bone Mineral Status ◽  
Cord Injury ◽  
Turnover Markers

Background. The study of late complications, including osteoporosis, is urgent due to the increasing life expectancy of patients with complete spinal cord injury (SCI). Objective. The aim of the study is to evaluate bone mineral status and bone turnover markers in the patients with chronic SCI.Methods. 73 SCI patients and 57 healthy persons were examined. Bone status was determined by ultrasound (US) densitometry. Bone turnover markers and vitamin D were evaluated by electrochemiluminescence method.Results. In the SCI patients bone mineral status was significantly lower compared with the individuals of control group. The stiffness index (SI) was 51.4±11.8 % vs. 98.5±16.6 %, p<0.05 in men and 50.1±9.8 % vs. 92.9±11.1 %, p<0.05 in women. In the SCI patients the levels of bone turnover markers were significantly higher than the reference values. The bone mineral status of patients with SCI, which occurred before peak bone mass development, is significantly worse, compared with the individuals with the already developed peak bone mass, that makes them a high risk group for fracture. Conclusions. SCI leads to increased bone resorption with development of secondary osteoporosis (according to the ultrasound densitometry of calcaneal bone). In chronic SCI, bone resorption is higher than in the individuals with combined low levels of vitamin D, and the absence of axial load results in continued loss of bone mass.

scholarly journals Periostin and sclerostin levels in individuals with spinal cord injury and their relationship with bone mass, bone turnover, fracture and osteoporosis status

Bone ◽  
2019 ◽  
Vol 127 ◽  
pp. 612-619 ◽  
Author(s):  
Laurent Maïmoun ◽  
Fayçal Ben Bouallègue ◽  
Anthony Gelis ◽  
Safa Aouinti ◽  
Thibault Mura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mass ◽  
Bone Turnover ◽  
Cord Injury

Effect of complete spinal cord injury on bone turnover and bone mineral density evolution: a 1 year follow-up study

2014 ◽  
Author(s):  
Laia Gifre ◽  
Joan Vidal ◽  
Silvia Ruiz-Gaspa ◽  
Enric Portell ◽  
Ana Monegal ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Mineral Density ◽  
Follow Up Study ◽  
Cord Injury ◽  
Complete Spinal Cord Injury

scholarly journals Extensive neurological recovery from a complete spinal cord injury: a case report and hypothesis on the role of cortical plasticity

2013 ◽  
Vol 7 ◽  
Author(s):  
Ann S. Choe ◽  
Visar Belegu ◽  
Shoko Yoshida ◽  
Suresh Joel ◽  
Cristina L. Sadowsky ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Cortical Plasticity ◽  
Neurological Recovery ◽  
Cord Injury ◽  
Complete Spinal Cord Injury

SAT0478 Effect of Complete Spinal Cord Injury on Bone Turnover and Bone Mineral Density (BMD) Evolution. A One Year Follow-Up Study

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 766.2-766
Author(s):  
L. Gifre ◽  
J. Vidal ◽  
E. Portell ◽  
A. Monegal ◽  
A. Muxi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Turnover ◽  
Mineral Density ◽  
Follow Up Study ◽  
Cord Injury ◽  
One Year ◽  
Complete Spinal Cord Injury

scholarly journals Data on the Quantification of Aspartate, GABA and Glutamine Levels in the Spinal Cord of Larval Sea Lampreys after a Complete Spinal Cord Injury

Data ◽  
2021 ◽  
Vol 6 (6) ◽  
pp. 54
Author(s):  
Blanca Fernández-López ◽  
Natividad Pereiro ◽  
Anunciación Lafuente ◽  
María Rodicio ◽  
Antón Barreiro-Iglesias
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Spinal Cord Transection ◽  
Cord Injury ◽  
Sea Lampreys ◽  
Complete Spinal Cord Injury

We used high-performance liquid chromatography (HPLC) methods to quantify aspartate, GABA, and glutamine levels in the spinal cord of larval sea lampreys following a complete spinal cord injury. Mature larval sea lampreys recover spontaneously from a complete spinal cord transection and the changes in neurotransmitter systems after spinal cord injury might be related to their amazing regenerative capabilities. The data presented here show the concentration of the aminoacidergic neurotransmitters GABA (and its precursor glutamine) and aspartate in the spinal cord of control (non-injured) and 2-, 4-, and 10-week post-lesion animals. Statistical analyses showed that GABA and aspartate levels significantly increase in the spinal cord four weeks after a complete spinal cord injury and that glutamine levels decrease 10 weeks after injury as compared to controls. These data might be of interest to those studying the role of neurotransmitters and neuromodulators in recovery from spinal cord injury in vertebrates.

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