Cow's milk allergic infants on amino acid-based medical nutrition formula maintain adequate serum concentrations of phosphorus, calcium and magnesium despite the use of acid-suppressive medication

The objective of this paper was to study the amino acid composition of donkey milk inhabiting the Kegety gorge of the Chui region. As well as human milk, donkey and mare’s milk is albumin; the amount of casein is 35-45%, while cow’s milk is casein milk with casein content over 75%. The peculiarity of albumin milk is a higher biological and nutritional value, due to better amino acid balance, high sugar content and the ability to form small, delicate flakes when souring. In terms of its properties, albumin milk is closest to human milk and is the best substitute for it. The obtained results showed that the quantitative content of 7 essential amino acids out of 8, such as lysine, phenylalanine, leucine, isoleucine, methionine, valine, threonine is relatively high compared to other amino acids. Despite the absence of tryptophan in donkey milk, the percentage of 8 essential amino acids in donkey milk protein exceeds that in mare and cow’s milk.

Download Full-text

Serum Immunoglobulins in Preterm Infants: Comparison of Human Milk and Formula Feeding

PEDIATRICS ◽

10.1542/peds.72.3.312 ◽

1983 ◽

Vol 72 (3) ◽

pp. 312-316 ◽

Cited By ~ 2

Author(s):

Erkki Savilahti ◽

Anna-Liisa Järvenpää ◽

Niels C. R. Räihä

Keyword(s):

Human Milk ◽

Preterm Infants ◽

Gestational Age ◽

Formula Feeding ◽

Cow’S Milk ◽

Serum Concentrations ◽

Cow's Milk ◽

Serum Immunoglobulins

Serum concentrations of immunoglobulins (IgA, IgG, and IgM) were studied in 64 preterm infants with gestational age of 31 to 36 weeks (mean 33.2 weeks), between 1 week and 4 months after birth. Infants were fed solely human milk or formula based on cow's milk. Infants fed formula exhibited significantly higher IgA levels at the age of 9 to 13 weeks than infants fed human milk. Infants given human milk who received more than 60% of their feeding in the hospital from their own mother had significantly higher IgA levels at the age of 3 weeks than did those receiving less than 30% of their feeding from their own mother. At 1 week of age, formula-fed infants with gestational age of 31 to 33 weeks had a significantly lower mean IgG concentration than those with gestational age of 34 to 36 weeks. However, the two term subgroups of infants receiving human milk, had similar mean concentrations of IgG and the value for infants of 31 to 33 weeks of gestation was significantly higher than that for formula-fed infants at the same gestational age. Serum IgM concentrations were similar whether infants were receiving human milk or formula. The formula feeding caused a more rapid maturation of IgA than did human milk. Results suggest that preterm infants may absorb IgA from the milk of their own mothers and that preterm infants with gestational age of 31 to 33 weeks may absorb IgG from human milk.

Download Full-text

A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey

Immunity Inflammation and Disease ◽

10.1002/iid3.288 ◽

2020 ◽

Vol 8 (1) ◽

pp. 93-105

Author(s):

Joris H. J. Sadelhoff ◽

Astrid Hogenkamp ◽

Selma P. Wiertsema ◽

Lucien F. Harthoorn ◽

Reinilde Loonstra ◽

...

Keyword(s):

Amino Acid ◽

Free Amino Acid ◽

Free Amino ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Cow's Milk Allergy

Download Full-text

A Thickened Amino-Acid Formula in Infants with Cow’s Milk Allergy Failing to Respond to Protein Hydrolysate Formulas: A Randomized Double-Blind Trial

Pediatric Drugs ◽

10.1007/s40272-014-0097-x ◽

2014 ◽

Vol 16 (6) ◽

pp. 513-522 ◽

Cited By ~ 10

Author(s):

Christophe Dupont ◽

Nicolas Kalach ◽

Pascale Soulaines ◽

Elena Bradatan ◽

Alain Lachaux ◽

...

Keyword(s):

Amino Acid ◽

Protein Hydrolysate ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Double Blind Trial ◽

Double Blind ◽

Cow's Milk ◽

Blind Trial ◽

Amino Acid Formula

Download Full-text

PNS37 Economic Analysis for Early Introduction of Amino Acid Formula for Cow's Milk Protein Allergy in the GCC Countries

Value in Health ◽

10.1016/j.jval.2020.08.1481 ◽

2020 ◽

Vol 23 ◽

pp. S650

Author(s):

M. Miqdady ◽

C. Tzivinikos ◽

A. Siddiqui ◽

S. Al Mutairy ◽

N. Al-Ahmedi ◽

...

Keyword(s):

Amino Acid ◽

Economic Analysis ◽

Milk Protein ◽

Cow’S Milk ◽

Early Introduction ◽

Cow's Milk ◽

Gcc Countries ◽

Cow’S Milk Protein ◽

Amino Acid Formula

Download Full-text

Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula

Pediatric Gastroenterology Hepatology & Nutrition ◽

10.5223/pghn.2021.24.4.392 ◽

2021 ◽

Vol 24 (4) ◽

pp. 392

Author(s):

Yvan Vandenplas ◽

Christophe Dupont ◽

Philippe Eigenmann ◽

Ralf G. Heine ◽

Arne Høst ◽

...

Keyword(s):

Amino Acid ◽

Milk Protein ◽

Cow’S Milk ◽

Cow's Milk ◽

Cow’S Milk Protein

Download Full-text

FPIES in exclusively breastfed infants: two case reports and review of the literature

Italian Journal of Pediatrics ◽

10.1186/s13052-020-00910-8 ◽

2020 ◽

Vol 46 (1) ◽

Author(s):

Francesco Baldo ◽

Martina Bevacqua ◽

Cristiana Corrado ◽

Daniela Nisticò ◽

Laura Cesca ◽

...

Keyword(s):

Amino Acid ◽

Medical Literature ◽

Challenge Test ◽

Cow’S Milk ◽

Diagnostic Process ◽

Food Protein ◽

Maternal Milk ◽

Cow's Milk ◽

Breastfed Infants ◽

History Of

Abstract Background Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non IgE-mediated food allergy that generally affects children in the first year of life. Usually symptoms break out when formula milk or solid foods are introduced for the first time but they might also appear in exclusively breastfed infants, since the trigger elements, especially cow’s milk proteins, can be conveyed by maternal milk as well. FPIES in exclusively breastfed babies is a very rare clinical condition and only few cases have been reported in the medical literature. Case presentation We describe two cases of FPIES in exclusively breastfed babies. The first one is a two-month-old infant with a brief history of vomit and diarrhea that presented to the Emergency Department in septic-like conditions. The main laboratory finding was a significant increase in methemoglobin (13%). Clinically, we noted that, when breastfeeding was suspended, diarrhea drastically improved, and vice versa when maternal milk was reintroduced. An amino acid-based formula allowed a complete normalization of the symptoms. The second one is a three-month-old infant admitted for a 3 days history of persistent vomit and diarrhea. Blood tests showed a raised level of methemoglobin (7%). An esophagogastroduodenoscopy was performed and biopsies showed an eosinophilic infiltration of the duodenal mucosa. A maternal exclusion diet and an amino acid-based formula allowed a rapid regularization of the bowel function. Conclusions We searched all the cases of FPIES in exclusively breastfed babies reported in the medical literature, identifying eight patients, with an average age of 3 months (range 15 days – 6 months). The majority of the cases were initially diagnosed as gastroenteritis or sepsis, five cases were characterized by an acute on chronic scenario and cow’s milk was the most frequently involved food. Methemoglobin was never tested. An oral food challenge test was performed in two patients. FPIES in exclusively breastfed infants is a rare condition that, in the presence of compatible history and symptoms, should be considered also in exclusively breastfed babies. The evaluation of methemoglobin can simplify the diagnostic process.

Download Full-text