scholarly journals Early arteriosclerosis and its risk factors in subjects with prediabetes and new-onset diabetes

2021 ◽  
Author(s):  
Xiaoli Liu ◽  
Lanxiang Liu ◽  
Rui Wang ◽  
Jia Xiaojiao ◽  
Binbin Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Resistance Index ◽  
Diabetes Group ◽  
Insulin Resistance Index ◽  
Onset Diabetes ◽  
Independent Risk Factors ◽  
New Onset

Background: We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes. Materials and Methods: A total of 148 participants who did not have diabetes mellitus were assigned to three groups through an oral glucose tolerance test: the normal glucose tolerance group; the impaired glucose regulation, also known as prediabetes, group; and the new-onset type 2 diabetes mellitus group. The insulin resistance index was assessed using the Homeostatic Model Assessment of Insulin Resistance. An enzyme-linked immunosorbent assay was used to determine the level of fibroblast growth factor 21. An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity and ankle-brachial index. baPWV, ABI, and FGF21 were used to assess early arteriosclerosis. Results: Significant differences in age, systolic blood pressure, fasting plasma glucose, 2-hour plasma glucose, 2-hour insulin, and HOMA-IR were found between the NGT group and the prediabetes and new-onset diabetes groups. All the above except 2hINS showed an increasing trend. FGF21 was higher in the new-onset diabetes group than in the NGT group, and baPWV was higher in the new-onset diabetes group than in the other two groups, but no significant difference was noted in ABI. Age, SBP, diastolic blood pressure, FPG, 2hPG, and FGF21 were positively correlated with baPWV. Moreover, BMI, SBP, DBP, FPG, 2hPG, and HOMA-IR were positively correlated with ABI. In addition, age, BMI, FPG, FGF21, and HOMA-IR were independent risk factors for baPWV, and SBP and HOMA-IR were independent risk factors for ABI. Conclusions: Patients with prediabetes and new-onset diabetes maybe have more significant early arteriosclerosis. The blood glucose level and insulin resistance index maybe the independent risk factors for early arteriosclerosis.

scholarly journals Early Arteriosclerosis and Its Risk Factors in Prediabetes and New-Onset Diabetes Subjects

2020 ◽  
Author(s):  
Xiaoli Liu ◽  
Lanxiang Liu ◽  
Rui Wang ◽  
Xiaojiao Jia ◽  
Binbin Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Glucose Tolerance ◽  
Resistance Index ◽  
Insulin Resistance Index ◽  
Onset Diabetes ◽  
Independent Risk Factors ◽  
New Onset

Abstract Background: We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes. Materials and Methods: A total of 148 participants without known diabetes mellitus were assigned to three groups: normal glucose tolerance (NGT); impaired glucose regulation (IGR), also known as prediabetes; and new-onset type 2 diabetes mellitus (T2DM) through an oral glucose tolerance test (OGTT). The insulin resistance index was assessed using the homeostasis model (HOMA-IR). An enzyme-linked immunosorbent assay was used to determine the expression level of the fibroblast growth factor 21 (FGF21). An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index (ABI). The baPWV, ABI and FGF21 were used to assess early arteriosclerosis. Results: Significant differences in age, systolic blood pressure (SBP), fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG), 2-hour insulin (2hINS) and HOMA-IR were found between the NGT group and the prediabetic and new-onset diabetic groups. All except 2hINS showed an increasing trend. The FGF21 and the baPWV increased from the NGT group to prediabetic and the new-onset diabetic group, but no significant difference was noted in the ABI. The age, SBP, diastolic blood pressure (DBP), FPG, 2hPG and FGF21 positively correlated with the baPWV. The BMI, SBP, DBP, FPG, 2hPG and HOMA-IR positively correlated with the ABI. The age, BMI, FPG, FGF21 and HOMA-IR were independent risk factors for the baPWV, and the SBP and the HOMA-IR were independent risk factors for ABI. Conclusions: Patients with prediabetes and new-onset diabetes had more significant early arteriosclerosis. The blood glucose and insulin resistance index were independent risk factors for early arteriosclerosis.

scholarly journals New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

2018 ◽  
Vol 2 (1) ◽  
pp. 35-40
Author(s):  
Sakthirajan R ◽  
Dhanapriya J ◽  
Dineshkumar T ◽  
Balasubramaniyan T ◽  
Gopalakrishnan N ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Family History ◽  
Fasting Blood Glucose ◽  
Hcv Infection ◽  
Clinical Profile ◽  
Family History Of Diabetes ◽  
Onset Diabetes ◽  
History Of ◽  
New Onset

Background: New onset diabetes after transplant (NODAT) remains one among the significant threats to both renal allograft and patient survival. The aim of this study was to analyse the clinical profile and risk factors for NODAT.Methods: This prospective observational study involved patients who underwent renal transplantation in our centre between 2010 and 2015.Results: During the mean follow up period of 18 ± 6 months, incidence of NODAT was 26.6% and the cumulativeincidence was highest in the first year after transplant. Recipient age, pre transplant impaired fasting glucose, Hepatitis C virus (HCV) infection, family history of diabetes, tacrolimus, post transplant hypertriglyceridemia and metabolic syndrome were found to be statistically significant risk factors for NODAT. In Cox multivariate regression analysis, age and family history of diabetes were found to be independent risk factors for NODAT. Fasting C-peptide level underlines insulin resistance as predominant mechanism for NODAT in two third of patients. There were higher incidence of urinary tract infection in the NODAT patients. NODAT was found to be an independent risk factor for fungal infection and 10 year cardiovascular risk in the renal recipients. There was no significant impact of NODAT on short term graft and patient survival.Conclusion: Age, pre-transplant fasting blood glucose, family history of diabetes, HCV infection and tacrolimus were found to be the important risk factors, with insulin resistance as the predominant mechanism for NODAT.

scholarly journals An Analysis of the Risk Factors for New-Onset Diabetes Mellitus After Liver Transplantation

2021 ◽  
Vol Volume 14 ◽  
pp. 4783-4792
Author(s):  
Jushan Sun ◽  
Yibiao He ◽  
Lei Bai ◽  
Zhipeng Wang ◽  
Zhu Cao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Liver Transplantation ◽  
Onset Diabetes ◽  
New Onset Diabetes Mellitus ◽  
New Onset

scholarly journals Risk factors for new-onset diabetes mellitus after distal pancreatectomy

2020 ◽  
Vol 8 (2) ◽  
pp. e001778
Author(s):  
Menghua Dai ◽  
Cheng Xing ◽  
Ning Shi ◽  
Shunda Wang ◽  
Guangdong Wu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Loss ◽  
Distal Pancreatectomy ◽  
College Hospital ◽  
True Rate ◽  
Preoperative Body Mass Index ◽  
Onset Diabetes ◽  
New Onset Diabetes Mellitus ◽  
New Onset

IntroductionSeveral previous studies have reported the incidence of new-onset diabetes mellitus (NODM) after pancreatectomy. Nevertheless, the results were inconsistent. The true rate of NODM after distal pancreatectomy (DP) is still unknown.Research design and methodsThe aim of this study was to investigate the incidence of and the risk factors for NODM after DP. This study enrolled patients who underwent DP between January 2004 and February 2016 at Peking Union Medical College Hospital. Patients with preoperative diabetes mellitus or diagnosed with pancreatic cancer were excluded. The primary outcome was NODM.ResultsA total of 485 patients were enrolled. The median (IQR) of follow-up duration was 30.95 (9.26–180.30) months. The accumulative incidence of NODM was 8.9% at postoperative 6 months, 14.0% at postoperative year one, 22.3% at year three, 27.1% at year five, and 35.5% at year ten. Multivariate analysis showed that the risk of postoperative NODM was positively correlated with age (HR 1.029 (1.013–1.045), p<0.001), preoperative body mass index (BMI) (HR 1.042 (1.003–1.083), p=0.001), operative blood loss (HR 1.0003 (1.0002–1.0010), p<0.001), and length of resected pancreas (HR 1.079 (1.013–1.148), p=0.017). Moreover, concomitant splenectomy (HR 2.001 (1.202–3.331), p=0.008) was associated with significantly higher risk of postoperative NODM.ConclusionNODM incidence increased with postoperative time progression. Age, BMI, surgical blood loss, length of resected pancreas and splenectomy were independent risk factors for NODM after DP.Trial registration numberNCT03030209.

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