Homocysteine is an indicator of arterial stiffness in Chinese women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular disease in women. Hyperhomocysteinemia (H-Hcy) is closely related to arterial stiffness (AS) in patients with cardiovascular disease. This study aimed to investigate the relationship between serum homocysteine (Hcy) level and brachial-ankle pulse wave velocity (baPWV) in Chinese women with PCOS. A total of 124 PCOS women were enrolled and divided into two groups according to their baPWV values: normal, baPWV <1400 cm/s; and high AS, baPWV ≥1400 cm/s. Univariate analysis was performed to investigate the relative factors for baPWV, and multiple regression analysis was used to evaluate the association of Hcy with baPWV. The group with high AS(n=35) had higher Hcy levels than the other group (n=89; P<0.05). Moreover, univariate analysis revealed that serum Hcy was positively correlated with baPWV (r = 0.133, P<0.01). In multiple regression analysis, the age-adjusted serum Hcy level was positively correlated with baPWV (β = 0.201, P<0.01). It remained positively associated with baPWV (β = 0.145, P<0.01) after further adjustments for age, body mass index, PCOS duration, systolic blood pressure and homeostasis model assessment-insulin resistance as well as several other factors correlated with baPWV. Our results demonstrated that H-Hcy was significantly and independently related to elevated baPWV, suggesting that Hcy might play a role in the pathologic process of AS in women with PCOS. Further researches with more subjects are needed to explore whether Hcy would be a promising biomarker for stratification management of PCOS women.

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Relationship between parasympathetic reactivity and oxidative stress in Polycystic ovary syndrome

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v14i2.44784 ◽

2020 ◽

Vol 14 (2) ◽

pp. 48-55

Author(s):

Ayesha Akhter ◽

Sultana Ferdousi ◽

Shamima Sultana ◽

Musfika Mostafa

Keyword(s):

Oxidative Stress ◽

Heart Rate ◽

Regression Analysis ◽

Polycystic Ovary Syndrome ◽

Multiple Regression Analysis ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Healthy Control ◽

And Oxidative Stress ◽

Plasma Malondialdehyde

Background: Polycystic ovary syndrome (PCOS) is a very common reproductive hormone disorder. Altered cardiovagal autonomic modulation and oxidative stress may predispose PCOS patients to increased cardiovascular morbidity. Objective: To assess the relationship between parasympathetic reactivity and oxidative stress in patients with PCOS. Methods: This crosssectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka from September 2018 to August 2019 on 35 newly diagnosed obese (BMI ≥25kg/m2) PCOS patients aged 20-35 years. Age and BMI matched 35 apparently healthy women were also enrolled as control. Three noninvasive conventional autonomic function tests, such as heart rate response to deep breathing, standing and the Valsalva maneuver, were used for evaluation of parasympathetic reactivity. For assessment of oxidative stress, plasma malondialdehyde level (oxidant) and plasma catalase level(antioxidant) were measured in all subjects by spectrophotometry. Data were expressed as mean± SD. For statistical analysis Independent sample “t” test, Pearson’s correlation test and multiple regression analysis were done as applicable. Results: In this study PCOS patients had significantly higher (p<0.01)resting heart rate, systolic and diastolic blood pressure than that of healthy control. But Expiration: Inspiration ratio, Expiration:Inspiration difference and 30:15 ratio during standing were significantly lower (p<0.001, p<0.01 and p<0.05 respectively) in PCOS compared to control. In addition, plasma catalase level was significantly lower (p<0.01)and plasma malondialdehyde level significantly higher (p<0.001) in PCOS in comparison to healthy control. Multiple regression analysis showed plasma catalase as a significant positive predictor (p<0.05) of the Valsalva ratio in PCOS. Also, Valsalva ratio showed significant negative association (p<0.05) with plasma malondialdehyde (p<0.01)in PCOS. Conclusion: Based on these results it is concluded that impaired parasympathetic reactivity showed inverse relationship with oxidative stress in PCOS. J Bangladesh Soc Physiol. 2019, December; 14(2): 48-55

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Association between renal hyperfiltration, arterial stiffness and subendocardial viability ratio in prediabetic subjects: a cross-sectional study.

10.21203/rs.3.rs-27648/v1 ◽

2020 ◽

Author(s):

Antonino Di Pino ◽

Simona Marchisello ◽

Roberto Scicali ◽

Luca Zanoli ◽

Viviana Ferrara ◽

...

Keyword(s):

Cardiovascular Disease ◽

Regression Analysis ◽

Arterial Stiffness ◽

Multiple Regression Analysis ◽

Multiple Regression ◽

Glomerular Hyperfiltration ◽

Model Assessment ◽

Renal Hyperfiltration ◽

Early Markers ◽

Subendocardial Viability Ratio

Abstract Background: Glomerular hyperfiltration is a well-recognized early renal alteration in subjects with diabetes mellitus and a strong and independent predictor of cardiovascular events in these patients. Prediabetes has been associated with increased glomerular filtration rate (GFR), however, the association between prediabetes, glomerular hyperfiltration and early markers of cardiovascular damage has not been investigated. The aim of this study was to investigate the association between renal hyperfiltration (RHF) and early markers of cardiovascular disease in subjects with prediabetes.Methods: Arterial stiffness [Augmentation Pressure (Aug), Augmentation Index (AugI)], subendocardial viability ratio (SEVR), pulse wave velocity (PWV), intima-media thickness (IMT), glycated hemoglobin (HbA1c), oral glucose tolerance test and estimated GFR (eGFR) were evaluated in 230 subjects with prediabetes. The eGFR was assessed using the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI). Hyperfiltration was defined as an eGFR above the 75th percentile.The subjects were divided into two groups according to the presence or absence of RHF: 169 subjects with prediabetes without RHF and 61 subjects with prediabetes with RHF.Results: Subjects with RHF showed higher Aug, AugI and lower SEVR compared with prediabetic subjects with lower eGFR (14.1±7.2 vs 10.8±6.2, 32.9±12.7 vs 27.6±11.7, 153.5±27.8 vs 162±30.2, P<0.05). No differences were found in PWV and IMT values between the two groups. We then performed multiple regression analysis to test the relationship between Aug, SEVR and several cardiovascular risk factors. In multiple regression analysis Aug was associated with age, systolic blood pressure (SBP), homeostatic model assessment for insulin resistance (HOMA-IR) and eGFR; the major determinants of SEVR were eGFR, HOMA-IR and SBP.Conclusions: Our data show that subjects with prediabetes and RHF exhibited an increased Aug, AugI and a reduced SEVR. Longitudinal studies are needed to explore whether hyperfiltration increases the possibility of diabetic nephropathy and cardiovascular disease in individuals with prediabetes.

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Association of three missense mutations in the homocysteine-related MTHFR and MTRR gene with risk of polycystic ovary syndrome in Southern Chinese women

Reproductive Biology and Endocrinology ◽

10.1186/s12958-020-00688-8 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Wanqin Feng ◽

Yan Zhang ◽

Yuan Pan ◽

Yi Zhang ◽

Minjuan Liu ◽

...

Keyword(s):

Regression Analysis ◽

Polycystic Ovary Syndrome ◽

Mediation Analysis ◽

Homocysteine Level ◽

Polycystic Ovary ◽

Linear Regression Analysis ◽

Dependent Manner ◽

Missense Mutations ◽

Ovary Syndrome ◽

Southern Chinese

Abstract Background The etiology between homocysteine and polycystic ovary syndrome (PCOS) is unclear. In humans, the level of homocysteine is mainly affected by two enzymes: methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR). While the activity of these two enzymes is mainly affected by three missense mutations, namely C677T (MTHFR), A1298C (MTHFR), and A66G (MTRR). This study aims to examine the association between the three missense mutations and PCOS and investigate whether the three missense mutations exerted their effect on PCOS by affecting the homocysteine level. Methods A case-control study was designed, comprising 150 people with PCOS and 300 controls. Logistic regression analysis was used to assess the association between the three missense mutations and PCOS. Linear regression analysis was used to assess the association between the three missense mutations and the homocysteine level. Mediation analysis was used to investigate whether the three missense mutations exerted their effect on PCOS by affecting the homocysteine level. Results Following adjustments and multiple rounds of testing, MTHFR A1298C was found to be significantly associated with PCOS in a dose-dependent manner (compared to AA, OR = 2.142 for AC & OR = 3.755 for CC; P < 0.001). MTRR A66G was nominally associated with PCOS. Mutations in MTHFR A1298C and MTRR A66G were significantly associated with the homocysteine level. Mediation analysis suggested the effect of MTHFR A1298C on PCOS was mediated by homocysteine. Conclusions MTHFR A1298C and MTRR A66G were associated with PCOS, and MTHFR A1298C might affect the risk of PCOS by influencing the homocysteine level.

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The mental health of Chinese women with polycystic ovary syndrome is related to sleep disorders, not disease status

Journal of Affective Disorders ◽

10.1016/j.jad.2020.12.084 ◽

2021 ◽

Vol 282 ◽

pp. 51-57

Author(s):

Yin Yang ◽

Hui Deng ◽

Tian Li ◽

Min Xia ◽

Chang Liu ◽

...

Keyword(s):

Mental Health ◽

Polycystic Ovary Syndrome ◽

Sleep Disorders ◽

Chinese Women ◽

Polycystic Ovary ◽

Disease Status ◽

Ovary Syndrome

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Increased arterial stiffness in mildly-hypertensive women with polycystic ovary syndrome

Journal of Obstetrics and Gynaecology Research ◽

10.1111/j.1447-0756.2010.01375.x ◽

2011 ◽

Vol 37 (5) ◽

pp. 402-411 ◽

Cited By ~ 16

Author(s):

Aiko Sasaki ◽

Yayoi Emi ◽

Miwa Matsuda ◽

Sharula ◽

Yasuhiko Kamada ◽

...

Keyword(s):

Arterial Stiffness ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome

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Polycystic ovary syndrome: a risk factor for cardiovascular disease?

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/j.1471-0528.2000.tb11572.x ◽

2000 ◽

Vol 107 (1) ◽

pp. 11-18 ◽

Cited By ~ 34

Author(s):

M. Rajkhowa ◽

M. R. Glass ◽

A. J. Rutherford ◽

K. Michelmore ◽

A. H. Balen

Keyword(s):

Cardiovascular Disease ◽

Risk Factor ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome

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Abstract P022: Self-reported Polycystic Ovary Syndrome Is Associated With Higher Odds Of Metabolic Syndrome In Women Aged 18-76 Years From The Hispanic Community Health Study/Study Of Latinos

Circulation ◽

10.1161/circ.143.suppl_1.p022 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Hridya C Rao ◽

Lindsay Fernandez-Rhodes ◽

Michelle Meyer ◽

Michelle Kominiarek ◽

Linda Gallo ◽

...

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Polycystic Ovary Syndrome ◽

Disease Risk ◽

Polycystic Ovary ◽

Health Study ◽

Latina Women ◽

Ovary Syndrome ◽

Hispanic Community ◽

Hs Crp

Introduction: Polycystic Ovary Syndrome (PCOS) is associated with increased Metabolic Syndrome (MetS), however, these findings have not been characterized in Hispanic/Latina women who are disproportionately burdened by obesity and cardiovascular disease risk compared to non-Hispanic whites. It is also unclear if this association is moderated by elevated high-sensitivity C-Reactive Protein (hs-CRP) levels, a marker for inflammation and a predictor of cardiovascular disease. Hypothesis: In Hispanic/Latina women, we hypothesized that 1) PCOS (self-reported diagnosis and signs) is associated with a higher prevalence of MetS compared to those not reporting PCOS 2) elevated hs-CRP is associated with MetS, and 3) the PCOS-MetS association is moderated by elevated hs-CRP. Methods: We used information from reproductive and economic questionnaires and venous blood measurements collected in Hispanic Community Health Study/Study of Latinos (2008-2017), a U.S. community-based cohort study of Hispanic/Latino adults. PCOS was operationalized as either 1) signs of PCOS (e.g., menstrual cycles >35 days, irregular cycles (at age 20 to 40 years old when not using birth control pills or other hormone medications and not pregnant or breastfeeding) or 2) having answered “yes” to a self-reported question on PCOS. MetS was operationalized as ≥3 elevated subcomponents of MetS (i.e., waist circumference, hypertension, insulin resistance, lipid profile, and triglycerides). A hs-CRP value ≥3.0 mg/L was considered elevated. We adjusted for the complex survey study design, age, study center, Hispanic/Latina background, and age at immigration in all models. Results: The overall (unweighted N=9582) age ranged from 18 to 76 years (mean=41.74, SD=14.18). The prevalence of PCOS (self-reported diagnosis and signs) was 12% (1008/7366), prevalence of MetS was 40% (2380/3495), prevalence of elevated-hsCRP was 44% (3704/4667). PCOS was associated with a significantly higher odds of MetS before (OR 1.35, 95% CI: 1.06-1.71) and after adjusting for elevated-hsCRP (OR 1.29, 95%CI: 1.02-1.65). Elevated hs-CRP is significantly associated with MetS (OR 2.31, 95%CI: 1.95-2.76). There was no significant interaction effect of hs-CRP in the PCOS-MetS association. Conclusions: Prevalence of PCOS (self-reported and signs) was 12% in our sample of Hispanic/Latina women, which is consistent with the previous findings in non-Hispanic whites. Both PCOS (self-reported diagnosis and signs) and elevated hs-CRP were significantly associated with higher prevalence of MetS and could indicate women at metabolic disease risk.

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