Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery

Objective Bariatric surgery has become the most effective treatment for morbid obesity. Increasing evidence showed that bariatric surgery can alleviate insulin resistance and influence thyroid function. This study aimed to investigate the relationship between changes in thyroid function and adipose tissue insulin resistance (adipo-IR) after bariatric surgery. Methods A total of 287 non-diabetic participants with regular thyroid function were recruited and divided into the lean, overweight and obese groups. Among them, 50 morbidly obese patients submitted to bariatric surgery. Results The obese group had a higher level of adipo-IR, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), FT3/free thyroxine (FT4) and metabolism disorders than the lean and overweight groups. BMI was correlated with TSH, FT3, FT3/FT4 and adipo-IR (r = 0.309, 0.315, 0.322 and 0.651, respectively, all P < 0.001). Adipo-IR was significantly correlated with TSH (r = 0.402, P < 0.001), FT3 (r = 0.309, P < 0.001), and FT3/FT4 (r = 0.228, P < 0.05). Bariatric surgery resulted in a sharp decline in BMI, adipo-IR, TSH, FT3 and FT3/FT4 levels, meanwhile, metabolic disorders improved. The decrease in BMI after bariatric surgery was significantly correlated with reductions in adipo-IR (r = 0.577, P < 0.001) and TSH (r = 0.401, P = 0.005). Interestingly, the fasting blood glucose, fasting insulin, adipo-IR and TSH in the higher TSH group decreased more remarkably than in the lower TSH group. Conclusion Obese individuals with higher TSH levels had an obvious metabolic improvement after bariatric surgery.

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The relationship between serum thyroid-stimulating hormone, insulin resistance, and cardiovascular risk factors in obese patients with subclinical hypothyroidism

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.16.8.2020.222879 ◽

2021 ◽

Vol 16 (8) ◽

pp. 630-635

Author(s):

N.V. Pasiechko ◽

Yu.V. Yevstratieva

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Subclinical Hypothyroidism ◽

Thyroid Stimulating Hormone ◽

Obese Patients ◽

Obese People ◽

The Relationship ◽

Tsh Levels

Background. The epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. The putative relationships between thyroid hormones, body weight, and adipose tissue homeostasis have been the focus of several studies in recent years, but the causal relationships between these parameters have not been well established. The purpose of the study: to investigate the relationship between serum thyroid-stimulating hormone (TSH), insulin resistance (IR), and cardiovascular risk factors in a sample of obese people with subclinical hypothyroidism. Materials and methods. A retrospective, longitudinal analysis of 145 obese patients was performed. The TSH and free thyroxine (fT4) levels, anthropometric measurements, and laboratory test results were analyzed. Results. Twenty-three individuals presented with TSH levels above the normal level (subclinical hypothyroidism). Their waist circumference (WC) was significantly higher than that of euthyroid individuals. Serum TSH positively correlated with the homeostasis model assessment of insulin resistance (HOMA-IR) index, triglycerides, and high-density lipoprotein cholesterol (HDL-C). Using TSH and body mass index as independent variables, TSH levels were shown to be independently related to HOMA-IR (p = 0.002) and triglycerides (p = 0.006). Among euthyroid subjects, individuals with TSH values < 2.5 mIU/ml exhibited statistically significant decreases in waist-to-hip ratio, HDL-C levels, and HOMA-IR scores and a tendency toward lower WC values. Conclusions. Subclinical hypothyroidism in overweight and obese people appears to be associated with excess weight, especially visceral weight. In the present sample of obese patients, TSH levels appear to be associated with insulin resistance.

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The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study

Clinical Medicine Insights Endocrinology and Diabetes ◽

10.4137/cmed.s24111 ◽

2015 ◽

Vol 8 ◽

pp. CMED.S24111 ◽

Cited By ~ 4

Author(s):

Juha Saltevo ◽

Hannu Kautiainen ◽

Pekka Mäntyselkä ◽

Antti Jula ◽

Sirkka Keinänen-Kiukaanniemi ◽

...

Keyword(s):

Regression Analysis ◽

Depressive Symptoms ◽

Thyroid Function ◽

Participation Rate ◽

Population Based ◽

Thyroid Stimulating Hormone ◽

Free Triiodothyronine ◽

Population Based Study ◽

The Mean ◽

The Relationship

The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depressive symptoms were 1.92/1.97 mU/L, 13.1/13.1 pmol/L, and 3.91/3.87 pmol/L (NS), respectively. In men, the levels were 1.87/1.94 mU/L, 13.5/13.7 pmol/L, and 4.18/4.12 pmol/L (NS), respectively. In multiple regression analysis, TSH had no relationship to BDI-21 total score. We found no association between depressive symptoms and thyroid values.

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Effects of thyroid hormone and depression on common components of central obesity

Journal of International Medical Research ◽

10.1177/0300060519851624 ◽

2019 ◽

Vol 47 (7) ◽

pp. 3040-3049 ◽

Cited By ~ 1

Author(s):

Fu-Man Du ◽

Hong-Yu Kuang ◽

Bin-Hong Duan ◽

Da-Na Liu ◽

Xin-Yang Yu

Keyword(s):

Central Obesity ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Epidemiological Studies ◽

Thyroid Stimulating Hormone ◽

Model Assessment ◽

Free Triiodothyronine ◽

Serum Tsh ◽

Tsh Levels

Objective We investigated the prevalence of abnormal thyroid function and depression in centrally obese participants, and to analyze the relationship of thyroid hormones and depression with components of central obesity. Methods We randomly selected 858 centrally obese participants and 500 non-obese controls in this study. For all participants, we measured serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), body mass index (BMI), waist–hip ratio (WHR), fasting blood glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid concentrations, and blood pressure. Depression was assessed using the Center for Epidemiological Studies-Depression (CES-D) scale. Results Centrally obese participants had a higher prevalence of hypothyroidism and depression than non-obese controls. Serum FT4 levels negatively correlated with BMI and serum TSH levels and positively correlated with BMI, WHR, total triglycerides (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C). After excluding participants with hypothyroidism and hyperthyroidism, serum FT4 levels showed negative correlation and serum TSH levels showed positive correlation with BMI in the remaining centrally obese participants. CES-D scores positively correlated with BMI. Conclusion We found high prevalences of hypothyroidism and depression among centrally obese participants. FT4 and TSH are important in weight regulation. Depression positively correlated with obesity.

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Obesity and hypothyroidism

Obesity and metabolism ◽

10.14341/2071-8713-4826 ◽

2013 ◽

Vol 10 (2) ◽

pp. 54-58 ◽

Cited By ~ 1

Author(s):

S M Zakharova ◽

L V Savelieva ◽

M I Fadeeva

Keyword(s):

Weight Loss ◽

Energy Expenditure ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Thyroid Stimulating Hormone ◽

Overt Hypothyroidism ◽

Obese Patients ◽

Common Diseases ◽

The Relationship ◽

Stimulating Hormone

Obesity and hypothyroidism are common diseases, and consequently clinicians should be particularly alert to the possibility of thyroid dysfunction in obese patients. The relationship between thyroid function and obesity is likely to be bidirectional, with hypothyroidism affecting weight, but obesity also influencing thyroid function. Both serum thyroid-stimulating hormone and fT3 are typically increased in obese individuals, an effect likely mediated by leptin. Following L-T4 treatment for overt hypothyroidism, weight loss appears to be modest and mediated primarily by loss of water weight rather than fat. Selected thyroid analogs might be a means by which to improve weight loss by increasing energy expenditure in obese patients during continued caloric deprivation

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Thyroid-stimulating hormone, leptin and insulin resistance in patients with obesity after bariatric surgery

Obesity and metabolism ◽

10.14341/omet11887 ◽

2020 ◽

Vol 17 (2) ◽

pp. 187-192

Author(s):

Anna R. Volkova ◽

Michael B. Fishman ◽

Galina V. Semikova

Keyword(s):

Insulin Resistance ◽

Bariatric Surgery ◽

Body Weight ◽

Thyroid Gland ◽

Resistance Index ◽

Thyroid Stimulating Hormone ◽

Obese Patients ◽

Free T4 ◽

Spontaneous Reduction ◽

Stimulating Hormone

BACKGROUND: The function of the thyroid gland effects on obesity and comorbidities. It has been proven for bariatric surgery to be the most effective in obesity treatment. AIM: to evaluate the dynamics of body weight, thyroid status, leptin and insulin resistance in obese patients after bariatric surgery. MATERIALS AND METHODS: 74 obese patients were observed after bariatric surgery (sleeve gastrectomy 42, gastric bypass - 32); initial body mass index (BMI), thyroid stimulating hormone, free T4, fasting plasma leptin, insulin and glucose were estimated; the insulin resistance index HOMA-IR was calculated. The dynamics of body weight was estimated by BMI and the excess BMI loss (% EBMIL). After 3 years of follow-up, 48 patients were examined. RESULTS: Subclinical hypothyroidism (SH) was detected in 36.5% of patients with high degrees of obesity. A correlation was found between BMI and TSH level (R=0.5; p=0.01). HOMA-IR was increased in most patients with obesity of the II and III degree (4.81.9 ng / ml). In the SH group, the leptin level was significantly higher than in the group with a normal TSH level of 43.07.3 ng / ml and 33.24.6 ng / ml (p=0.004). Among patients with initial SH, spontaneous reduction of TSH levels occurred in 45% patients 3 years after surgery. CONCLUSIONS: Postoperatively, the BMI decrease was associated with the decrease of TSH, leptin and HOMA-IR. The data obtained may reflect the effect of adipose tissue on the functional state of the thyroid gland in patients with high degrees of obesity after bariatric surgery. This seems to be extremely important for maintaining body weight.

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Effects of bariatric surgery on insulin resistance and insulin secretion in morbidly obese patients

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2007-972465 ◽

2007 ◽

Vol 115 (S 1) ◽

Author(s):

M Promintzer ◽

G Prager ◽

M Stadler ◽

C Anderwald ◽

M Mandl ◽

...

Keyword(s):

Insulin Resistance ◽

Bariatric Surgery ◽

Insulin Secretion ◽

Morbidly Obese ◽

Obese Patients

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Effects of a Single Venous Dose of Zinc on Thyroid Status in Healthy Individuals and Patients With Graves' Disease

Metal-Based Drugs ◽

10.1155/mbd.2000.151 ◽

2000 ◽

Vol 7 (3) ◽

pp. 151-155 ◽

Cited By ~ 3

Author(s):

Lubna Farooqi ◽

Gláucia M. F. S. Mazeto ◽

Tadao Shuhama ◽

José Brandão-Neto

Keyword(s):

Thyroid Function ◽

Plasma Levels ◽

Thyroid Stimulating Hormone ◽

Graves Disease ◽

Zinc Metabolism ◽

Healthy Individuals ◽

Free Triiodothyronine ◽

Hormone Synthesis ◽

Hyperthyroid Patients ◽

Tsh Levels

Zinc metabolism may regulate thyroid function acting at TRH (thyrotropin-releasing hormone) synthesis, peripheral deiodination of T4 (tetraiodothyronine), and binding of thyroid hormones to nuclear receptors. The aim of this study was to investigate the effect of acute zinc administration on TSH (thyroid-stimulating hormone), FT3 (free triiodothyronine), and FT4 (free tetraiodothyronine) in 10 healthy individuals and 12 hyperthyroid patients with Graves' disease. All these individuals were studied following 25 mg Zn++ administered intravenously, at 7:00 a.m. after 12 h fast. Blood samples collected at 0, 3, 30, 60, 90, and 120 min after zinc administration showed no significant alteration in the plasma levels of TSH, FT3, and FT4 in hyperthyroid patients. There were no changes in the plasma levels of FT3 and FT4 in the control subjects, but TSH levels were acutely depressed by zinc administration. This study suggests that zinc given acutely and in pharmacological doses does not affect thyroid function in hyperthyroid subjects, but affect plasma TSH levels in healthy individuals.

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