Mass screening of newborns for congenital hypothyroidism of central origin by free thyroxine measurement of blood samples on filter paper

Abstract From out data bank, we analyzed results for thyroxine concentration in blood samples spotted on filter paper from different age groups (one to nine days postpartum) of our low-birth-weight and normal population. It was significantly lower in the low-birth-weight infants in almost all the age groups, and in both groups it significantly declined after postnatal day 5. The influence of weight is more important in the low-birth-weight population, but does not completely explain the smaller values. The results indicate that blood samples used in screening for congenital hypothyroidism in the neonate should be taken on postnatal days 3 to 5, and if a recall specimen is collected on days 5 to 9, one should expect the thyroxine concentration in the second specimen to be lower than in the first.

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TSH AND THYROXINE IN STORED NEONATAL FILTER-PAPER BLOOD SAMPLES FROM PATIENTS WITH CONGENITAL HYPOTHYROIDISM

Acta Paediatrica ◽

10.1111/j.1651-2227.1982.tb09369.x ◽

1982 ◽

Vol 71 (1) ◽

pp. 39-41 ◽

Cited By ~ 4

Author(s):

A. LARSSON ◽

J. G. LJUNGGREN ◽

K. LUNDBERG

Keyword(s):

Congenital Hypothyroidism ◽

Filter Paper ◽

Blood Samples

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Prostate-specific antigen assay using whole blood samples spotted on filter paper and its application to mass screening for prostate cancer

International Journal of Urology ◽

10.1111/j.1442-2042.2007.01772.x ◽

2007 ◽

Vol 14 (6) ◽

pp. 505-509 ◽

Cited By ~ 2

Author(s):

Masaharu Nanri ◽

Kazushige Nanri ◽

Chisato Fujiyama ◽

Yuji Tokuda ◽

Kiyoko Nakamura ◽

...

Keyword(s):

Prostate Cancer ◽

Prostate Specific Antigen ◽

Mass Screening ◽

Filter Paper ◽

Whole Blood ◽

Specific Antigen ◽

Blood Samples ◽

Antigen Assay ◽

Whole Blood Samples

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beta-Lipoprotein quantitation in cord blood spotted on filter paper: a screening test.

Clinical Chemistry ◽

10.1093/clinchem/26.9.1285 ◽

1980 ◽

Vol 26 (9) ◽

pp. 1285-1290 ◽

Cited By ~ 11

Author(s):

G D Vladutiu ◽

C J Glueck ◽

M T Schultz ◽

S McNeely ◽

R Guthrie

Keyword(s):

Cord Blood ◽

Total Cholesterol ◽

Mass Screening ◽

Filter Paper ◽

Screening Test ◽

Type Ii ◽

Blood Samples ◽

Paired Samples ◽

Familial Type ◽

Blood Specimens

Abstract We describe an electroimmunodiffusion technique for measuring beta-lipoprotein in cord blood spotted on filter paper. A series of cord-blood samples, taken from 916 consecutive live-birth infants, was spotted directly onto filter paper and assayed for beta-lipoprotein. Eleven had above-normal beta-lipoprotein. Of these 11, seven were tested two to six months later, along with their parents, for total cholesterol and triglyceride concentrations. Five infants had increased cholesterol values, and four parents of these infants had either increased cholesterol or triglyceride values. We also measured beta-lipoprotein concentrations in 63 paired samples of dried cord-blood and three-day post-delivery blood specimens, routinely collected for phenylketonuria screening. We saw a significant correlation between results for the specimens, but detected no cases of increased beta-lipoprotein. beta-Lipoprotein assay in dried specimens of cord blood is simple, inexpensive, and potentially is useful in mass screening of newborns for familial type II and combined hyperlipidemia.

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