scholarly journals Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study

2012 ◽  
Vol 166 (4) ◽  
pp. 669-677 ◽  
Author(s):  
Guido Di Dalmazi ◽  
Valentina Vicennati ◽  
Eleonora Rinaldi ◽  
Antonio Maria Morselli-Labate ◽  
Emanuela Giampalma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Multivariate Logistic Regression Analysis ◽  
Cardiovascular Outcomes ◽  
Intermediate Phenotype ◽  
Diagnostic Tools ◽  
Subclinical Hypercortisolism ◽  
Intermediate Phenotypes ◽  
Free Cortisol ◽  
Potential Risk Factors

BackgroundSubclinical Cushing's syndrome (SCS) is defined as alterations in hypothalamic–pituitary–adrenal axis without classic signs/symptoms of glucocorticoid excess. Whether SCS leads to metabolic and cardiovascular diseases is still controversial.AimTo evaluate the prevalence of hypertension, type 2 diabetes (T2D), coronary heart disease (CHD), ischemic stroke, osteoporosis, and fractures, and their relationship to increasing patterns of subclinical hypercortisolism, in patients with nonsecreting adrenal adenomas (NSA) and SCS.MethodsUsing the 1 mg dexamethasone suppression test (DST), 348 patients were classified as follows: 203 were defined as NSA and 19 SCS, using the most stringent cutoff values (<50 and >138 nmol/l respectively). Patients with cortisol post-DST (50–138 nmol/l) were considered as intermediate phenotypes and classified as minor (n=71) and major (n=55) using plasma ACTH and/or urinary free cortisol as additional diagnostic tools.ResultsSCS patients showed higher prevalence of T2D, CHD, osteoporosis, and fractures with respect to NSA. Intermediate phenotypes also showed higher prevalence of CHD and T2D with respect to NSA. The prevalence of all clinical outcomes was not different between intermediate phenotype patients, which were therefore considered as a single group (IP) for multivariate logistic regression analysis: both IP and SCS-secreting patterns showed a significant association with CHD (odds ratio (OR), 4.09; 95% confidence interval (CI), 1.47–11.38 and OR, 6.10; 95% CI, 1.41–26.49 respectively), independently of other potential risk factors. SCS was also independently associated with osteoporosis (OR, 5.94; 95% CI, 1.79–19.68).ConclusionsPatterns of increasing subclinical hypercortisolism in adrenal adenomas are associated with increased prevalence of adverse metabolic and cardiovascular outcomes, independently of other potential risk factors.

Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

1990 ◽  
Vol 63 (01) ◽  
pp. 013-015 ◽  
Author(s):  
E J Johnson ◽  
C R M Prentice ◽  
L A Parapia
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Potential Risk ◽  
Antithrombin Iii ◽  
Arterial Disease ◽  
Coagulation System ◽  
Early Age ◽  
Arterial Thromboembolism ◽  
Potential Risk Factors ◽  
Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

Classification of Potential Risk Factors through HIRARC Method in Assessing Indoor Environment of Museums

2018 ◽  
Vol 10 (8) ◽  
Author(s):  
Syahrun Neizam Mohd Dzulkifli ◽  
◽  
Abd Halid Abdullah ◽  
Yee Yong Lee ◽  
Mohd Mahathir Suhaimi Shamsuri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Indoor Environment ◽  
Potential Risk Factors

Lack of Social Support and Social Trust as Potential Risk Factors for Dry Eye Disease: JPHC-NEXT Eye Study

2018 ◽  
Author(s):  
Chi Hoang Viet Vu ◽  
Miki Uchino ◽  
Motoko Kawashima ◽  
Akihiro Nishi ◽  
Christopher A. German ◽  
...  
Keyword(s):  
Risk Factors ◽  
Social Support ◽  
Dry Eye ◽  
Potential Risk ◽  
Social Trust ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Potential Risk Factors

scholarly journals Low frequency of local findings in periprosthetic hip infection caused by low-virulent bacteria compared to periprosthetic knee infection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Imagama ◽  
Kazushige Seki ◽  
Toshihiro Seki ◽  
Yuta Matsuki ◽  
Kazuhiro Yamazaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Bacterial Species ◽  
Joint Infection ◽  
Sinus Tract ◽  
Musculoskeletal Infection ◽  
Knee Infection ◽  
Hip Infection ◽  
Potential Risk Factors ◽  
Periprosthetic Knee Infection

AbstractPeriprosthetic joint infection (PJI) is suspected when local findings such as pain, swelling, hyperthermia, and sinus tract are present. However, the frequency of these findings and the difference between hip and knee are unclear. This study compared the positive rates of local findings in periprosthetic hip infection (PHI) with periprosthetic knee infection (PKI), and aimed to identify potential risk factors associated with the frequency. One hundred one PJI (46 hips and 55 knees) fulfilled the 2018 Musculoskeletal infection society criteria were analysed retrospectively to assess the positive rates of each local finding. Patients were categorized into two groups based on the presence or absence of each local finding, and the influence of two potential risk factors [body mass index (BMI) and C-reactive protein (CRP)] was investigated. Causative bacterial species were divided into high and low-virulent groups, and then culture negative cases were included in low-virulent group. PHI had significantly lower rates of pain, swelling and hyperthermia compared to PKI. Overall, up to one-third of PHI had pain as only symptom. High BMI and low-virulent bacteria were associated with lower frequency of swelling and hyperthermia in PHI. CRP had no impact on positive rates of local findings. PHI was oligosymptomatic in a significant percentage of cases. This is particularly important in obese patients and infection by low-virulent bacteria.

scholarly journals Parental metal exposures as potential risk factors for spina bifida in Bangladesh

2021 ◽  
Vol 157 ◽  
pp. 106800
Author(s):  
Gwen Tindula ◽  
Sudipta Kumer Mukherjee ◽  
Sheikh Muhammad Ekramullah ◽  
D.M. Arman ◽  
Subrata Kumar Biswas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Spina Bifida ◽  
Potential Risk ◽  
Potential Risk Factors
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