scholarly journals Biochemical testing on wide indication to detect overt hypothyroidism is justified: a population-based case--control study in patients newly diagnosed with overt autoimmune hypothyroidism

2013 ◽  
Author(s):  
Allan Carle ◽  
Inge Bulow Pedersen ◽  
Nils Knudsen ◽  
Lars Ovesen ◽  
Lone Banke Rasmussen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Overt Hypothyroidism ◽  
Newly Diagnosed ◽  
Autoimmune Hypothyroidism ◽  
Biochemical Testing ◽  
Control Study

scholarly journals Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

2012 ◽  
Vol 167 (4) ◽  
pp. 483-490 ◽  
Author(s):  
Allan Carlé ◽  
Inge Bülow Pedersen ◽  
Nils Knudsen ◽  
Hans Perrild ◽  
Lars Ovesen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Case Control Study ◽  
Reference Group ◽  
Population Based ◽  
Case Control ◽  
Overt Hypothyroidism ◽  
Autoimmune Hypothyroidism ◽  
Normal Thyroid Function ◽  
Control Study

ObjectiveAlcohol consumption is an important protective risk factor for many autoimmune diseases. We wished to study the association between alcohol consumption and autoimmune hypothyroidism.DesignPopulation-based, case–control study, 1997–2001, Denmark.MethodsPatients with newly diagnosed autoimmune overt hypothyroidism (n=140) were prospectively identified in a population (2 027 208 person-years of observation), and their matched controls with normal thyroid function (n=560) were recruited simultaneously from the same population. Participants gave information on alcohol intake, smoking, previous diseases, education, and family history of hypothyroidism. The association between alcohol intake and development of hypothyroidism was analyzed in conditional regression models.ResultsHypothyroid cases had reported a lower alcohol consumption than controls (median units of alcohol (12 g) per week: 3 vs 5,P=0.002). In a multivariate regression model, alcohol consumption was associated with a reduction in risk for development of overt autoimmune hypothyroidism. Odds ratios (95% confidence interval) compared with the reference group with a recent (last year) consumption of 1–10 units of alcohol per week were as follows: 0 units/week, 1.98 (1.21–3.33); 11–20 units/week, 0.41 (0.20–0.83); and ≥21 units/week, 0.90 (0.41–2.00). Similar results were found for maximum previous alcohol consumption during a calendar year. No interaction was found with type of alcohol consumed (wine vs beer), sex, or region of inhabitancy.ConclusionsAlcohol consumption seems to confer considerable protection against development of overt autoimmune hypothyroidism irrespective of sex and type of alcohol consumed.

scholarly journals Risk of Premotor Symptoms in Patients with Newly Diagnosed PD: A Nationwide, Population-Based, Case-Control Study in Taiwan

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130282 ◽  
Author(s):  
Yu-Hsuan Wu ◽  
Yi-Chu Liao ◽  
Yi-Huei Chen ◽  
Ming-Hong Chang ◽  
Ching-Heng Lin
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Association of Prodromal Type 1 Diabetes With School Absenteeism of Danish Schoolchildren: A Population-Based Case-Control Study of 1,338 Newly Diagnosed Children

Diabetes Care ◽  
2020 ◽  
Vol 43 (11) ◽  
pp. 2886-2888
Author(s):  
Peter R. Thingholm ◽  
Amanda Gaulke ◽  
Tine M. Eriksen ◽  
Jannet Svensson ◽  
Niels Skipper
Keyword(s):  
Type 1 Diabetes ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
School Absenteeism ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Association between tonsillitis and newly diagnosed ankylosing spondylitis: A nationwide, population-based, case-control study

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0220721
Author(s):  
Wen-Cheng Chao ◽  
Ching-Heng Lin ◽  
Yi-Ming Chen ◽  
Rong-San Jiang ◽  
Hsin-Hua Chen
Keyword(s):  
Ankylosing Spondylitis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Air pollutants and development of interstitial lung disease in patients with connective tissue disease: a population-based case–control study in Taiwan

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e041405
Author(s):  
Hsin-Hua Chen ◽  
You-Ming Yong ◽  
Ching-Heng Lin ◽  
Yi-Hsing Chen ◽  
Der-Yuan Chen ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Connective Tissue ◽  
Lung Disease ◽  
Air Pollutants ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Air Pollutant ◽  
Newly Diagnosed ◽  
Control Study

ObjectiveThe aim of this study was to assess the association between air pollutant exposure and interstitial lung disease (ILD) in patients with connective tissue diseases (CTDs).SettingA nationwide, population-based, matched case–control study in Taiwan.ParticipantsUsing the 1997–2013 Taiwanese National Health Insurance Research Database, we identified patients with newly diagnosed CTD during 2001–2013, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), dermatomyositis (DMtis)/polymyositis (PM) and primary Sjögren’s syndrome (pSS).Primary and secondary outcome measuresPatients with newly diagnosed ILD during 2012–2013 were identified as ILD cases, and selected patients with CTD without ILD matching (1:4) the CTD cases for CTD diagnosis, age, gender, disease duration and year of ILD diagnosis date were identified as non-ILD controls. Data of hourly level of air pollutants 1 year before the index date were obtained from the Taiwan Environmental Protection Agency. The association between ILD and air pollutant exposure was evaluated using logistic regression analysis shown as adjusted ORs (aORs) with 95% CIs after adjusting for potential confounders.ResultsWe identified 505 newly diagnosed CTD-ILD patients, including 82 with SLE, 210 with RA, 47 with SSc, 44 with DMtis/PM and 122 with pSS. Ozone (O3) exposure (per 10 ppb) was associated with a decreased ILD risk in patients with CTD (aOR, 0.51; 95% CI, 0.33 to 0.79) after adjusting for potential confounders.ConclusionsA previously unrecognised inverse correlation was found between O3 exposure and ILD in patients with RA and SSc. Further studies are warranted to explore the underlying mechanisms.

Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study

2012 ◽  
Vol 72 (7) ◽  
pp. 1206-1211 ◽  
Author(s):  
Hsin-Hua Chen ◽  
Nicole Huang ◽  
Yi-Ming Chen ◽  
Tzeng-Ji Chen ◽  
Pesus Chou ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Index Date ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Case Control ◽  
Time Interval ◽  
Newly Diagnosed ◽  
History Of ◽  
Control Study

ObjectiveTo investigate the association between the risk of rheumatoid arthritis (RA) and a history of periodontitis.MethodsThis nationwide, population-based, case–control study used administrative data to identify 13 779 newly diagnosed patients with RA (age ≥16 years) as the study group and 137 790 non-patients with RA matched for age, sex, and initial diagnosis date (index date) as controls. Using conditional logistic regression analysis after adjustment for potential confounders, including geographical region and a history of diabetes and Sjögren's syndrome, ORs with 95% CI were calculated to quantify the association between RA and periodontitis. To evaluate the effects of periodontitis severity and the lag time since the last periodontitis visit on RA development, ORs were calculated for subgroups of patients with periodontitis according to the number of visits, cumulative cost, periodontal surgery and time interval between the last periodontitis-related visit and the index date.ResultsAn association was found between a history of periodontitis and newly diagnosed RA (OR=1.16; 95% CI 1.13 to 1.21). The strength of this association remained statistically significant after adjustment for potential confounders (OR=1.16; 95% CI 1.12 to 1.20), and after variation of periodontitis definitions. The association was dose- and time-dependent and was strongest when the interval between the last periodontitis-related visit and the index date was <3 months (OR=1.64; 95% CI 1.49 to 1.79).ConclusionsThis study demonstrates an association between periodontitis and incident RA. This association is weak and limited to lack of individual smoking status.

Sign in / Sign up

Export Citation Format

Share Document