Linear growth and IGF1 concentrations in children cyanotic and acyanotic congenital heart disease before vs after intervention

Children with acyanotic congenital heart disease frequently develop respiratory difficulties such as atelectasis, pneumonia, or infantile lobar emphysema. In some cases, the cause of the respiratory difficulty is compression of the tracheobronchial tree by hypertensive dilated pulmonary arteries, since this type of heart disease frequently demonstrates large left-to-right intracardiac shunts. Sites of predilection for compression include the left main bronchus, the left upper lobe bronchus, the junction of the right bronchus intermedius and right middle lobe bronchus, and the left side of the distal trachea. Cardiac anomalies which predispose to this type of compression include ventricular septal defect, patent ductus arteriosus, interruption of the aortic arch, and tetralogy of Fallot. Pulmonary arteriopexy may relieve the tracheobronchial compression.

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PULMONARY COMPLICATIONS OF CONGENITAL HEART DISEASE

PEDIATRICS ◽

10.1542/peds.43.5.757 ◽

1969 ◽

Vol 43 (5) ◽

pp. 757-758

Author(s):

A. M. R.

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Respiratory Distress ◽

Pulmonary Disease ◽

Cardiac Failure ◽

Congenital Heart ◽

Pulmonary Infection ◽

Pulmonary Complications ◽

High Incidence ◽

Acyanotic Congenital Heart Disease

Respiratory distress is a very frequent symptom in infants with acyanotic congenital heart disease. Some of the specific physiological and pathological mechanisms involved in this association have been presented in Pediatrics.1 That communication stressed the frequency with which cardiac failure associated with large left-to-right shunts presents with respiratory distress, often misinterpreted as being due to pulmonary disease. It has, however, also been long recognized that there is a high incidence of pulmonary infection in infants with large left-to-right shunt lesions. The cause of these frequent infections in such patients is not yet evident, but a possible explanation now seems to be suggested from recent observations at autopsy.

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Chapter-05 Acyanotic Congenital Heart Disease

Step by Step Pediatric Echocardiography ◽

10.5005/jp/books/10853_5 ◽

2004 ◽

pp. 39-62

Author(s):

Rani Gera

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Acyanotic Congenital Heart Disease

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Acyanotic congenital heart disease

Heart Disease in Pregnancy ◽

10.1093/med/9780199574308.003.0089 ◽

2011 ◽

pp. 177-190

Author(s):

Dawn Adamson ◽

Mandish Dhanjal ◽

Catherine Nelson-Piercy

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Acyanotic Congenital Heart Disease

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The effect of cyanotic and acyanotic congenital heart disease on children’s growth velocity

Paediatrica Indonesiana ◽

10.14238/pi57.3.2017.160-3 ◽

2017 ◽

Vol 57 (3) ◽

pp. 160

Author(s):

Dewi Awaliyah Ulfah ◽

Endang Dewi Lestari ◽

Harsono Salimo ◽

Sri Lilijanti Widjaya ◽

Bagus Artiko

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Growth Velocity ◽

Congenital Heart ◽

Failure To Thrive ◽

Upper Respiratory Tract ◽

Chi Square ◽

Central Java ◽

Acyanotic Congenital Heart Disease ◽

The Impact

Background Congenital heart disease (CHD) can lead to failure to thrive. Decreased energy intake, malabsorption, increased energy requirements, and decreased growth factors (growth hormone/insulin-like growth factor 1 axis) are related to malnutrition and growth retardation in children with CHD.Objective Tocompare the impact of cyanotic and acyanotic CHD on children’s growth velocity (using the 2009 WHO growth velocity chart).Methods This study was conducted in patients less than 24 months of age with CHD in the Pediatric Cardiology Specialist Unit Dr. Moewardi Hospital, Surakarta, Central Java, from December 2016 to February 2017. Subjects’ weights were evaluated at the beginning of the study and two months later. Data were compared to the WHO Growth Velocity chart and analyzed by Chi-square test.Results Of 46 patients with CHD (23 cyanotic, 23 acyanotic), 10 patients (21.7%) were identified with failure to thrive, i.e., < 5th percentile. Significantly more children with acyanotic CHD were in the >5th percentile for growth velocity than were children with cyanotic CHD (OR 5.600; 95%CI 1.038 to 30.204; P=0.032). Acute upper respiratory tract infection was not significantly associated with growth velocity (OR 2.273; 95%CI 0.545 to 9.479; P=0.253).Conclusion Children with cyanotic CHD have 5.6 times higher risk of failure to thrive than children with acyanotic CHD.

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Cyanotic and acyanotic congenital heart disease

10.1016/b978-0-323-70849-4.00017-7 ◽

2022 ◽

pp. 33-40

Author(s):

Robert Vezzetti

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Acyanotic Congenital Heart Disease

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Serum immunoreactive erythropoietin in children with cyanotic and acyanotic congenital heart disease

Blood ◽

10.1182/blood.v70.3.822.822 ◽

1987 ◽

Vol 70 (3) ◽

pp. 822-826 ◽

Cited By ~ 20

Author(s):

P Haga ◽

PM Cotes ◽

JA Till ◽

BD Minty ◽

EA Shinebourne

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Oxygen Content ◽

Congenital Heart ◽

Geometric Mean ◽

Significant Negative Correlation ◽

Mean Value ◽

Arterial Oxygen ◽

Arterial Oxygen Content ◽

Acyanotic Congenital Heart Disease

Abstract Serum immunoreactive erythropoietin (siEp) was measured in 27 cyanotic and 21 acyanotic children with congenital heart disease, age 4 months to 10 years. The geometric mean value was 9 mIU/mL for each group with 95% range from 3 to 26 mIU/mL and 4 to 22 mIU/mL for the cyanotic and acyanotic subjects, respectively. The levels are similar to those found in normal adults using the same assay system. Three cyanotic subjects showed increased siEp values. One was anemic relative to his hypoxemia, and the other two showed signs of increasing hypoxia. There was a significant negative correlation between siEp and arterial oxygen content. However, siEp did not correlate significantly with hemoglobin, hematocrit, PaO2, or SaO2. Despite normal siEp levels, the cyanotic children showed compensatory erythropoiesis with significantly elevated hemoglobin and hematocrit levels, which did correlate inversely with PaO2 and SaO2. Arterial oxygen content was also significantly higher in the cyanotic subjects (p less than 0.02). The cyanotic children seemed to display the same pattern as observed in man and animals exposed to prolonged hypobaric hypoxia, where after an initial rise in erythropoietin values the levels fall to normal, while increased erythropoiesis is sustained.

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Pattern of Congenital Heart Disease in Children Presenting at Paediatric Cardiology Unit in Chattagram Maa Shishu-O-General Hospital, Chittagong

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v16i2.37292 ◽

2018 ◽

Vol 16 (2) ◽

pp. 40-43

Author(s):

Sukhendu Shekhar Sen ◽

Tanuka Barua ◽

Dipika Dey ◽

Mahmood A Chowdhury ◽

Lutfan Nessa

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Early Detection ◽

Congenital Heart ◽

Septal Defect ◽

Color Doppler ◽

Mortality And Morbidity ◽

Diagnostic Facility ◽

Disease Pattern ◽

Acyanotic Congenital Heart Disease

Background: Congenital Heart Disease (CHD) is the most common congenital problem in children. Early detection and proper management of congenital heart disease is very important to reduce mortality and morbidity. The purpose of this study was to find out the disease pattern of CHD among children in present situation in a center outside Dhaka.Methods: This study was conducted over a period from March 2016 to June 2017 prospectively and all patients with CHD was diagnosed by Color Doppler Echocardiography aging from 1st day of life to 12 years were included in the study.Results: Acyanotic CHD was most common among CHD. Atrial Septal Defect (ASD) was the commonest acyanotic congenital heart disease 100 (35.7 %) followed by Ventricular Septal Defect (VSD) 77 (27.5 %). Commonest cyanotic CHD was Tetralogy of Fallot (TOF) 9 (3.2 %). Only 25.36 % CHD were diagnosed during neonatal period whereas 54.64 % were diagnosed during the period of 29 days to completion of 12 months. Most of the patient (63.21%) were male.Conclusion: ASD was the commonest acyanotic CHD whereas TOF was the commonest cyanotic CHD. About 80% cases were diagnosed before 1 year of age. With the advancement of diagnostic facility and neonatal care, early detection of CHD is possible and treatment can be started at an earlier age.Chatt Maa Shi Hosp Med Coll J; Vol.16 (2); July 2017; Page 40-43

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