scholarly journals Study of irisin hormone level in type 2 diabetic patients with and without diabetic neuropathy

2015 ◽  
Author(s):  
Mohammad Halawa ◽  
Manal Abushady ◽  
Mohammed Abd El Fattah ◽  
Mohammed Hassan
Keyword(s):  
Diabetic Neuropathy ◽  
Hormone Level ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Effect of Glycemic Control on Electrophysiologic Changes of Diabetic Neuropathy in Type 2 Diabetic Patients

2005 ◽  
Vol 21 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Chun-Chiang Huang ◽  
Chia-Ling Lee ◽  
Mao-Hsiung Huang ◽  
Tien-Wen Chen ◽  
Ming-Cheng Weng ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Diabetic Neuropathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Study of irisin hormone level in type 2 diabetic patients and patients with diabetic nephropathy

2015 ◽  
Author(s):  
Salah Shelbaya ◽  
Manal Abushady ◽  
Merhan Samy ◽  
El Mageed Yasmin Abd ◽  
Magdy Abbas
Keyword(s):  
Diabetic Nephropathy ◽  
Hormone Level ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Case Series: Reversal of Diabetic Neuropathy Utilizing Physiologic Insulin Resensitization

2021 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Wound Healing ◽  
Diabetic Neuropathy ◽  
Cell Function ◽  
Case Series ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Skin Breakdown ◽  
Type 2 Diabetic

Diabetes is a growing global problem that is currently on the rise. Type 2 diabetes (T2D) is a chronic condition that results from aberrant B-cell function coupled with progressive insulin resistance. The majority of Type 2 diabetic patients develop diabetic neuropathy, which can lead to devastating complications (i.e., infection, ulceration, osteomyelitis, & amputation). The proinflammatory state of diabetes, along with prolonged hyperglycemia damages peripheral nerves (most common in the lower extremities). Additionally, compromised wound healing exacerbates the risk when skin breakdown occurs in this patient population. To overcome these risks for T2D, physiologic insulin resensitization (PIR) has been used as a novel protocol to treat patients with severe neuropathy symptoms. In our case study, we present two patients who initially experienced a loss of sensation in their extremities and decreased wound healing. Using PIR treatment, we demonstrate that both patients experienced neuropathy reversal and improved wound healing.

Diabetic neuropathy in elderly Type 2 diabetic patients: effects of insulin treatment

2009 ◽  
Vol 98 (5) ◽  
pp. 346-353 ◽  
Author(s):  
J. Tovi ◽  
E. Svanborg ◽  
B.-Y. Nilsson ◽  
P. Engfeldt
Keyword(s):  
Diabetic Neuropathy ◽  
Insulin Treatment ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Relative Fat Mass, a new tool for measuring obesity, could predict the complications of type 2 diabetes

2021 ◽  
Vol 5 (3) ◽  
pp. 01-08
Author(s):  
Isabelle Jambart
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Diabetic Neuropathy ◽  
Fat Mass ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Aim/background: Obesity is a chronic disease contributing to many metabolic illnesses, in particular type 2 diabetes. The Relative Fat Mass (RFM) is a tool recently introduced for obesity which better predicts the level of visceral fat than the Body Mass Index (BMI). The aim of this study is to determine whether RFM is a better predictor of the cardiometabolic risk factors and the complications of type 2 diabetes than BMI. Materials and methods: This is a cross sectional study. A list of information was collected from endocrinologists treating type 2 diabetic patients in a primary healthcare clinic and a tertiary hospital in Beirut. This list allowed us to evaluate the micro and macro vascular complications of type 2 diabetic patients, to assess their risk factors and to calculate their RFM and BMI. Results: We analyzed the data of 359 patients. Higher RFM was associated with higher systolic blood pressure (p < 0.05), and both RFM and BMI were significantly correlated to higher CRP, triglyceride levels and liver enzymes. However, the BMI was better associated with other cardiometabolic risk factors such as the total cholesterol (p = 0,003), LDL cholesterol (p = 0,002) and HbA1c (p = 0,01) than RFM. Both RFM and BMI were correlated with higher microalbuminuria (p < 0.001) but unlike BMI, higher RFM was associated with higher creatinine level (p = 0.317 versus 0.047 respectively) and therefore better linked to diabetic nephropathy than BMI. More importantly, we observed an unprecedented result, associating RFM to diabetic neuropathy: a normal RFM excludes diabetic neuropathy with a high probability of 82.5%. Furthermore, a RFM cutoff value of 30.76 in men and 43.31 in women showed an increased risk of developing diabetic neuropathy by 2.464. No association was observed between RFM and diabetic retinopathy. Conclusion: The RFM better predicts microvascular complications of diabetes than BMI except for retinopathy. It is also associated with a worse profile of metabolic syndrome. This study is unique in its discovery of the potential role of RFM as a tool which could rule out neuropathy in diabetic patients.

scholarly journals Plasma total homocysteine is not associated with peripheral neuropathy in a groups Bangladeshi type 2 diabetic subjects

2012 ◽  
Vol 11 (4) ◽  
pp. 335-342
Author(s):  
MM Rahman ◽  
Z Hassan ◽  
KB Biswas ◽  
NB Bhowmik ◽  
L Ali
Keyword(s):  
Diabetic Neuropathy ◽  
Nerve Conduction ◽  
Sensory Nerve ◽  
Plasma Homocysteine ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Conduction Velocities ◽  
Total Homocysteine ◽  
Type 2 Diabetic

Aims: The present study was undertaken to explore the relationship of plasma homocysteine in the pathogenesis of neuropathy in diabetic patients.Subjects and Methods: Forty two type 2 diabetic patients [22 with neuropathy (DN group) and 20 without neuropathy (DNN group)], age range between 35-70 years had relatively controlled glycemia and duration of diabetes 7-15 years, were studied. Motor and sensory nerve conduction velocities and action potential amplitudes of peripheral nerves were determined by following standard protocol. HbA1c was estimated by modified HPLC (BIO-RAD Variant, USA). Serum C-peptide was measured by enzyme linked immunosorbentassay (ELISA), plasma total homocysteine by Fluorescent Polarization Immunoassay (FPIA). Results: Age, BMI and blood pressure of the study subjects were. Duration of diabetes between DN and DNN groups was comparable. DN group had significantly higher fasting glucose levels (9.8±3.8, mmol/l) compared to the DNN group (6.9±1.8, p=0.004). This trend was also reflected in the HbA1c level: 8.7± 2.1 vs 7.2±1.6 in DN group and DNN group respectively (p=0.009). The two diabetic groups had relatively higher absolute C-peptide level compared to the controls (p=ns). DN and DNN groups had significantly higher plasma homocysteine level compared to the Controls. But between the two diabetic groups no significant difference was observed. Ulnar and peroneal motor nerve conduction velocities and compound muscle action potentials in the diabetic neuropathy group significantly lower compared to diabetic counterpart and the controls. Ulnar and sural sensory nerve conduction velocities and action potentials were significantly lower in the diabetic neuropathy group compared to the diabetic counterpart and the controls. Plasma homocysteine did not show any correlation with nerve conduction velocities  and action potential amplitudes.Conclusions: The data concluded that (i) Diabetic neuropathy may not  be related to hyperhomocysteinemia in type 2 diabetic patients of Bangladeshi origin; (ii) Hyperglycemia, even at milder level, is related to neuronal dysfunction in these subjects; and (ii) Hyperinsulinemia don't seem to be prerequisite for neuropathy in these subjects. DOI: http://dx.doi.org/10.3329/bjms.v11i4.12607 Bangladesh Journal of Medical Science Vol. 11 No. 04 Oct’12  

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