Incidence and peculiarities of thyroid cancer in patients with type 2 diabetes mellitus

Aim. The incidence of thyroid cancer is increasing worldwide. The prevalence of type 2 diabetes mellitus (T2DM) is also increasing. Therefore, we aimed to analyze the effect of T2DM on thyroid cancer. Methods. A case-control study was performed. A total of 415 healthy controls with thyroid ultrasound screening and physician consultation were selected from the Thyroid Cancer Longitudinal Study (T-CALOS). Among patients with thyroid cancer who were enrolled in T-CALOS, 415 patients were matched to the control group according to age and sex. We assessed the effects of T2DM, T2DM duration, and T2DM medication on thyroid cancer. Results. Women with T2DM had lower odds of thyroid cancer than women without T2DM (odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.20–0.81). Individuals receiving T2DM medication had higher odds of thyroid cancer compared to those without T2DM medication (OR: 5.21, 95% CI: 1.58–17.15). Individuals with T2DM duration <6 years had lower odds of thyroid cancer compared to those without T2DM (OR: 0.58, 95% CI: 0.34–0.97). Conclusions. Individuals with early T2DM are presumed to have a low incidence of thyroid cancer, and this effect seems to last up to 6 years after diagnosis of T2DM.

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Prediabetes and type 2 diabetes mellitus and risk of thyroid cancer

Endocrine Abstracts ◽

10.1530/endoabs.56.p1148 ◽

2018 ◽

Author(s):

Tereza Grimmichova ◽

Petr Matucha

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Thyroid Cancer

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Increased risk of type 2 diabetes in patients with thyroid cancer after thyroidectomy: A nationwide cohort study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab776 ◽

2021 ◽

Author(s):

Eun Roh ◽

Eunjin Noh ◽

Soon Young Hwang ◽

Jung A Kim ◽

Eyun Song ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cohort Study ◽

Thyroid Cancer ◽

Cancer Patients ◽

Reference Group ◽

Increased Risk ◽

Quartile Group

Abstract Context Abnormal thyroid function after thyroidectomy and subsequent thyroid-stimulating hormone suppression can have detrimental effects on glucose homeostasis in thyroid cancer patients. Objective To investigate whether thyroidectomy increases the risk of type 2 diabetes in thyroid cancer patients and to explore the association between levothyroxine dosage and type 2 diabetes risk. Design A retrospective population-based cohort study. Setting The Korean National Health Insurance database. Participants We included 36,377 thyroid cancer patients without known diabetes who underwent thyroidectomy between 2004 and 2013. Matched non-thyroid cancer subjects were selected using 1:1 propensity score matching. Main Outcome Measure Newly developed type 2 diabetes mellitus. Results Thyroid cancer patients who underwent thyroidectomy had a higher risk of developing type 2 diabetes mellitus than the matched controls (hazard ratio [HR]: 1.43, 95% confidence interval [CI]: 1.39–1.47). Among thyroid cancer patients, when the second quartile group (in terms of the mean levothyroxine dosage; 101–127 μg/day) was considered the reference group, the risk of type 2 diabetes mellitus increased in the first quartile (<101 μg/day; HR: 1.45, 95% CI: 1.36–1.54) and fourth quartile groups (≥150 μg/day; HR: 1.37, 95% CI: 1.29–1.45); meanwhile, the risk decreased in the third quartile group (128–149 μg/day; HR: 0.91, 95% CI: 0.85–0.97). Conclusion Thyroid cancer patients who underwent thyroidectomy were more likely to develop type 2 diabetes mellitus than the matched controls. There was a U-shaped dose-dependent relationship between the levothyroxine dosage and type 2 diabetes mellitus risk.

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The Association Between Type 2 Diabetes Mellitus, Hypothyroidism, and Thyroid Cancer

Acta Clinica Croatica ◽

10.20471/acc.2020.59.s1.17 ◽

2020 ◽

Author(s):

Željko Zubčić

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Thyroid Cancer

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The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and Risk of Type 2 Diabetes Mellitus and Thyroid Cancer

10.21203/rs.3.rs-674870/v1 ◽

2021 ◽

Author(s):

Su Hyun Lee ◽

Joyce Mary Kim ◽

Young Wook Lim ◽

Youn Seok Kang ◽

Keum Ji Jung ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Cancer Research ◽

Type 2 Diabetes Mellitus ◽

Thyroid Cancer ◽

Epidemiological Studies ◽

Cancer Research Institute ◽

Human Carcinogen ◽

Research Institute

Abstract Background and Objectives: Dioxin, classified as a human carcinogen by International Cancer Research Institute, shows inconsistent results on type 2 diabetes mellitus (T2DM) and cancer in epidemiological studies. International Cancer Research Institute classifies dioxin as a human carcinogen, but epidemiological studies of its effects on type 2 diabetes mellitus (T2DM) and cancer show inconsistent results. Therefore, we conducted a Korean population study to ascertain if the blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) is associated with T2DM and thyroid cancer.Methods: Within a nested case-control study, we identified 15 people diagnosed with thyroid cancer, 30 people diagnosed with T2DM, and 55 for control. Due to the 4ml human blood requirement for PCDD/DF and DL-PCB concentrations tests, a total of 500 samples were used in 100 pooling samples. The continuous variable of a pooled sample was calculated as an average value taking into account the blood weight of each sample. The odds ratios (ORs) and 95% confidence interval (95% CI) for determining the association between total dioxins and risk of T2DM and thyroid cancer were estimated using the multivariable logistic regression.Results: The study population included 100 participants from the KCPS-II (median [IQR] baseline age, 54.06 [21.04] years; 48 women). The toxic equivalents of PCDD/DFs showed a significant positive association with T2DM and thyroid cancer, after adjustments for potential confounders (T2DM ORs = 1.23; 95% CI = 1.05-1.43; Thyroid cancer ORs = 1.34; 95% CI = 1.12-1.61). These results showed a stronger association in women than in men.Conclusion: In this study, both T2DM and thyroid cancer appear to be associated with the levels of PCDD/DFs serum. The association between T2DM and levels of PCDD/DFs serum is found in women and not in men. Our findings suggest that further biochemical in vivo research and epidemiologic studies are needed to clarify the nature of the association between dioxins concentrations and diseases.

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