scholarly journals The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and Risk of Type 2 Diabetes Mellitus and Thyroid Cancer

2021 ◽  
Author(s):  
Su Hyun Lee ◽  
Joyce Mary Kim ◽  
Young Wook Lim ◽  
Youn Seok Kang ◽  
Keum Ji Jung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cancer Research ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Cancer ◽  
Epidemiological Studies ◽  
Cancer Research Institute ◽  
Human Carcinogen ◽  
Research Institute

Abstract Background and Objectives: Dioxin, classified as a human carcinogen by International Cancer Research Institute, shows inconsistent results on type 2 diabetes mellitus (T2DM) and cancer in epidemiological studies. International Cancer Research Institute classifies dioxin as a human carcinogen, but epidemiological studies of its effects on type 2 diabetes mellitus (T2DM) and cancer show inconsistent results. Therefore, we conducted a Korean population study to ascertain if the blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) is associated with T2DM and thyroid cancer.Methods: Within a nested case-control study, we identified 15 people diagnosed with thyroid cancer, 30 people diagnosed with T2DM, and 55 for control. Due to the 4ml human blood requirement for PCDD/DF and DL-PCB concentrations tests, a total of 500 samples were used in 100 pooling samples. The continuous variable of a pooled sample was calculated as an average value taking into account the blood weight of each sample. The odds ratios (ORs) and 95% confidence interval (95% CI) for determining the association between total dioxins and risk of T2DM and thyroid cancer were estimated using the multivariable logistic regression.Results: The study population included 100 participants from the KCPS-II (median [IQR] baseline age, 54.06 [21.04] years; 48 women). The toxic equivalents of PCDD/DFs showed a significant positive association with T2DM and thyroid cancer, after adjustments for potential confounders (T2DM ORs = 1.23; 95% CI = 1.05-1.43; Thyroid cancer ORs = 1.34; 95% CI = 1.12-1.61). These results showed a stronger association in women than in men.Conclusion: In this study, both T2DM and thyroid cancer appear to be associated with the levels of PCDD/DFs serum. The association between T2DM and levels of PCDD/DFs serum is found in women and not in men. Our findings suggest that further biochemical in vivo research and epidemiologic studies are needed to clarify the nature of the association between dioxins concentrations and diseases.

scholarly journals The Association between Type 2 Diabetes Mellitus and Thyroid Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Young-Gyun Seo ◽  
Ho-Chun Choi ◽  
Ah Reum An ◽  
Do Joon Park ◽  
Young Joo Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Cancer ◽  
Control Group ◽  
Ultrasound Screening ◽  
Lower Odds ◽  
Low Incidence ◽  
Control Study

Aim. The incidence of thyroid cancer is increasing worldwide. The prevalence of type 2 diabetes mellitus (T2DM) is also increasing. Therefore, we aimed to analyze the effect of T2DM on thyroid cancer. Methods. A case-control study was performed. A total of 415 healthy controls with thyroid ultrasound screening and physician consultation were selected from the Thyroid Cancer Longitudinal Study (T-CALOS). Among patients with thyroid cancer who were enrolled in T-CALOS, 415 patients were matched to the control group according to age and sex. We assessed the effects of T2DM, T2DM duration, and T2DM medication on thyroid cancer. Results. Women with T2DM had lower odds of thyroid cancer than women without T2DM (odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.20–0.81). Individuals receiving T2DM medication had higher odds of thyroid cancer compared to those without T2DM medication (OR: 5.21, 95% CI: 1.58–17.15). Individuals with T2DM duration <6 years had lower odds of thyroid cancer compared to those without T2DM (OR: 0.58, 95% CI: 0.34–0.97). Conclusions. Individuals with early T2DM are presumed to have a low incidence of thyroid cancer, and this effect seems to last up to 6 years after diagnosis of T2DM.

scholarly journals The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. e020062 ◽  
Author(s):  
Xiaosu Bai ◽  
Zhiming Liu ◽  
Zhisen Li ◽  
Dewen Yan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Cochrane Library ◽  
Increased Risk

ObjectivesSeveral patients with type 2 diabetes mellitus (T2DM) have depressive disorders. Whether insulin treatment was associated with increased risk of depression remains controversial. We performed a meta-analysis to evaluate the association of insulin therapy and depression.DesignA meta-analysis.MethodsWe conducted a systematic search of PubMed, PsycINFO, Embase and the Cochrane Library from their inception to April 2016. Epidemiological studies comparing the prevalence of depression between insulin users and non-insulin users were included. A random-effects model was used for meta-analysis. The adjusted and crude data were analysed.ResultsTwenty-eight studies were included. Of these, 12 studies presented with adjusted ORs. Insulin therapy was significantly associated with increased risk of depression (OR=1.41, 95% CI 1.13 to 1.76, p=0.003). Twenty-four studies provided crude data. Insulin therapy was also associated with an odds for developing depression (OR=1.59, 95% CI 1.41 to 1.80, p<0.001). When comparing insulin therapy with oral antidiabetic drugs, significant association was observed for adjusted (OR=1.42, 95% CI 1.08 to 1.86, p=0.008) and crude (OR=1.61, 95% CI 1.35 to 1.93, p<0.001) data.ConclusionsOur meta-analysis confirmed that patients on insulin therapy were significantly associated with the risk of depressive symptoms.

scholarly journals Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus

2007 ◽  
Vol 26 (5) ◽  
pp. 447-452 ◽  
Author(s):  
Anna Rignell-Hydbom ◽  
Lars Rylander ◽  
Lars Hagmar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Odds Ratio ◽  
Epidemiological Studies ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Persistent Organochlorine ◽  
Organochlorine Pollutants

Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (CB-153) and p,p'-DDE in 544 serum-samples from Swedish women with a median age of 50 years. The participants were asked if they had diabetesand if so, what type of diabetes, years since diagnosis and what kind of treatment they had. Associations between exposure and T2DM were analysed by logistic regression. Moreover, trends of T2DM prevalence were tested with Jonckheere-Terpstra' test. Sixteen of the 544 women (3%) had diabetes, of which15 were classified as T2DM. There was a significant associationwith T2DM for both CB-153 (an increase of 100ng/glipid corresponded to an odds ratio [OR] of 1. 6, 95% confidenceinterval [CI] 1. 0, 2. 7) and p,p9-DDE (OR 1. 3, 95%CI 1. 1, 1. 6). In addition, significant positive trends betweenquartiles of CB-153 and T2DM (P 5 0. 004) and p,p9-DDEand T2DM (P 5 0. 002) were observed. The study showsan association between POP serum concentrations andan increased prevalence of T2DM. Human & Experimental Toxicology (2007) 26, 447—451

scholarly journals Mechanisms underlying the comorbidity of schizophrenia and type 2 diabetes mellitus

2020 ◽  
Author(s):  
Yutaka Mizuki ◽  
Shinji Sakamoto ◽  
Yuko Okahisa ◽  
Yuji Yada ◽  
Nozomu Hashimoto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Low Socioeconomic Status ◽  
Neuronal Development ◽  
Epidemiological Studies ◽  
Susceptibility Genes ◽  
Low Socioeconomic

Abstract The mortality rate of patients with schizophrenia is high, and life expectancy is shorter by 10 to 20 years. Metabolic abnormalities including type 2 diabetes mellitus (T2DM) are among the main reasons. The prevalence of T2DM in patients with schizophrenia may be epidemiologically frequent because antipsychotics induce weight gain as a side effect and the cognitive dysfunction of patients with schizophrenia relates to a disordered lifestyle, poor diet, and low socioeconomic status. Apart from these common risk factors and risk factors unique to schizophrenia, accumulating evidence suggests the existence of common susceptibility genes between schizophrenia and T2DM. Functional proteins translated from common genetic susceptibility genes are known to regulate neuronal development in the brain and insulin in the pancreas through several common cascades. In this review, we discuss common susceptibility genes, functional cascades, and the relationship between schizophrenia and T2DM. Many genetic and epidemiological studies have reliably associated the comorbidity of schizophrenia and T2DM, and it is probably safe to think that common cascades and mechanisms suspected from common genes’ functions are related to the onset of both schizophrenia and T2DM. On the other hand, even when genetic analyses are performed on a relatively large number of comorbid patients, the results are sometimes inconsistent, and susceptibility genes may carry only a low or moderate risk. We anticipate future directions in this field.

The interaction of the dentist with an endocrinologist – a team approach in the treatment of inflammatory periodontal diseases in patients with type 2 diabetes mellitus (literature review)

2019 ◽  
Vol 24 (2) ◽  
pp. 140-144
Author(s):  
T. G. Petrova ◽  
N. B. Borodina ◽  
S. D. Rymar ◽  
O. D. Rymar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Epidemiological Studies ◽  
Team Approach ◽  
Therapeutic Implications

Relevance. Numerous epidemiological studies have found a high degree of association between DM and periodontal disease, and periodontal disease has even been proposed as a sixth complication of DM. It has also been demonstrated that this relationship is bidirectional, with periodontitis exerting an effect on DM. These fndings have diagnostic and therapeutic implications. Thus, the high prevalence of periodontal disease in DM indicates the need to evaluate glucose levels in periodontal patients. Conversely, intervention studies have demonstrated that the treatment of periodontal disease improves the glycemic control of DM patients. To alert health professionals about the risk that periodontitis represents for the onset or exacerbation of complications in individuals with type 2 diabetes mellitus (DM) and to emphasize that the mechanical treatment of periodontal disease and reestablishment of oral health are essential for the metabolic control of these patients.Materials and methods. A review of the literature on the topic of 30 sources from them 5 domestic and 25 foreign data.Some researchers demonstrate the Periodontal screening must be part of the overall clinical examination of patients with diabetes and, if diagnosed, periodontal disease must be treated appropriately to avoid or exacerbate diabetes complications besides improving glycemic control in these individuals.Results: In the postoperative period during the frst three days, patients of both groups had moderate soft tissue edema, slight flap hyperemia and palpation pain.Conclusions. Increased knowledge of dentists, endocrinologists and the public is required to improve early diagnosis of diabetes, adequate management, prevention and treatment of dental diseases in patients with DM.

scholarly journals Study of vitamin d levels in patients with type 2 diabetes mellitus

2021 ◽  
Vol 9 (1) ◽  
pp. 13-20
Author(s):  
Dr. J.V. Srujan ◽  
◽  
Dr. Surya Prakash Rao ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Study Results

Introduction: Diabetes is defined as a disturbance in intermediary metabolism manifesting aschronic sustained hyperglycemia, primarily due to either an absolute or a relative lack of insulin.Many epidemiological studies have demonstrated an inverse relationship between vitamin D levelsand diabetes mellitus. However, there is a paucity of literature regarding the levels of vitamin D intype 2 diabetes, which is common in our community. This study was taken up to shed more light onthis issue. Material and methods: This was a cross-sectional study conducted at NRI Institute ofMedical Sciences, Sangivalasa, Visakhapatnam district. Cases of Type 2 Diabetes Mellitus attendingto the outpatient department, diagnosed as per the ADA criteria of 2011, between the ages of 31and 75 years constituted the material for the present study. Results and conclusion: Vitamin Dlevels were found to be significantly lower in the study group (19.91±7.0 ng/ml) as compared to thecontrol group (32.22±4.0 ng/ml).

Increased risk of type 2 diabetes in patients with thyroid cancer after thyroidectomy: A nationwide cohort study

2021 ◽  
Author(s):  
Eun Roh ◽  
Eunjin Noh ◽  
Soon Young Hwang ◽  
Jung A Kim ◽  
Eyun Song ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Study ◽  
Thyroid Cancer ◽  
Cancer Patients ◽  
Reference Group ◽  
Increased Risk ◽  
Quartile Group

Abstract Context Abnormal thyroid function after thyroidectomy and subsequent thyroid-stimulating hormone suppression can have detrimental effects on glucose homeostasis in thyroid cancer patients. Objective To investigate whether thyroidectomy increases the risk of type 2 diabetes in thyroid cancer patients and to explore the association between levothyroxine dosage and type 2 diabetes risk. Design A retrospective population-based cohort study. Setting The Korean National Health Insurance database. Participants We included 36,377 thyroid cancer patients without known diabetes who underwent thyroidectomy between 2004 and 2013. Matched non-thyroid cancer subjects were selected using 1:1 propensity score matching. Main Outcome Measure Newly developed type 2 diabetes mellitus. Results Thyroid cancer patients who underwent thyroidectomy had a higher risk of developing type 2 diabetes mellitus than the matched controls (hazard ratio [HR]: 1.43, 95% confidence interval [CI]: 1.39–1.47). Among thyroid cancer patients, when the second quartile group (in terms of the mean levothyroxine dosage; 101–127 μg/day) was considered the reference group, the risk of type 2 diabetes mellitus increased in the first quartile (&lt;101 μg/day; HR: 1.45, 95% CI: 1.36–1.54) and fourth quartile groups (≥150 μg/day; HR: 1.37, 95% CI: 1.29–1.45); meanwhile, the risk decreased in the third quartile group (128–149 μg/day; HR: 0.91, 95% CI: 0.85–0.97). Conclusion Thyroid cancer patients who underwent thyroidectomy were more likely to develop type 2 diabetes mellitus than the matched controls. There was a U-shaped dose-dependent relationship between the levothyroxine dosage and type 2 diabetes mellitus risk.

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