Effects of dexamethasone and adrenocorticotropin on circulating microRNA expression in humans

2015 ◽  
Author(s):  
Ivan Igaz ◽  
Gabor Nyiro ◽  
Zoltan Nagy ◽  
Pal Perge ◽  
Miklos Toth ◽  
...  
Keyword(s):  
Microrna Expression ◽  
Circulating Microrna

scholarly journals Analysis of Circulating microRNA Signatures and Preeclampsia Development

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1003
Author(s):  
Margarita L. Martinez-Fierro ◽  
Idalia Garza-Veloz
Keyword(s):  
Pregnant Women ◽  
Expression Profiling ◽  
Gene Prediction ◽  
Microrna Expression ◽  
Differentially Expressed ◽  
Control Group ◽  
Case Group ◽  
Circulating Microrna ◽  
Activated T Cells ◽  
Serum Microrna

microRNAs are important regulators of cell processes and have been proposed as potential preeclampsia biomarkers. We evaluated serum microRNA expression profiling to identify microRNAs involved in preeclampsia development. Serum microRNA expression profiling was evaluated at 12, 16, and 20 weeks of gestation (WG), and at the time of preeclampsia diagnosis. Two groups were evaluated using TaqMan low-density array plates: a control group with 18 normotensive pregnant women and a case group with 16 patients who developed preeclampsia during the follow-up period. Fifty-three circulating microRNAs were differentially expressed between groups (p < 0.05). Compared with controls, hsa-miR-628-3p showed the highest relative quantity values (at 12 WG = 7.7 and at 20 WG = 3.45) and the hsa-miRs -151a-3p and -573 remained differentially expressed from 16 to 20 WG (p < 0.05). Signaling pathways including cancer-related, axon guidance, Neurotrophin, GnRH, VEGF, and B/T cell receptor, were most commonly altered. Further target gene prediction revealed that nuclear factor of activated T-cells 5 gene was included among the transcriptional targets of preeclampsia-modulated microRNAs. Specific microRNAs including hsa-miRs -628-3p, -151a-3p, and -573 were differentially expressed in serum of pregnant women before they developed preeclampsia compared with controls and their participation in the preeclampsia development should be considered.

scholarly journals Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Evguenia Nepotchatykh ◽  
Wesam Elremaly ◽  
Iurie Caraus ◽  
Christian Godbout ◽  
Corinne Leveau ◽  
...  
Keyword(s):  
Treatment Options ◽  
Expression Patterns ◽  
Chronic Fatigue ◽  
Microrna Expression ◽  
Myalgic Encephalomyelitis ◽  
Circulating Microrna ◽  
Prevention Measures ◽  
Case Definitions ◽  
Specific Symptom ◽  
Fatigue Syndrome

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM. Our findings highlight the differential expression of eleven microRNAs associated with a physiological response to PEM. The present study uncovers specific microRNA expression signatures associated with ME/CFS in response to PEM induction and reports microRNA expression patterns associated to specific symptom severities. The identification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevention measures, and effective treatment options.

scholarly journals Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3

2016 ◽  
Vol 12 (4) ◽  
pp. 2220-2226 ◽  
Author(s):  
Chaoyu Sun ◽  
Lei Tong ◽  
Wenran Zhao ◽  
Yan Wang ◽  
Yuan Meng ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Coxsackievirus B3 ◽  
Microrna Expression ◽  
Circulating Microrna

Sensitive detection of melanoma metastasis using circulating microRNA expression profiles

2013 ◽  
Vol 23 (5) ◽  
pp. 366-372 ◽  
Author(s):  
Rie Shiiyama ◽  
Satoshi Fukushima ◽  
Masatoshi Jinnin ◽  
Junji Yamashita ◽  
Azusa Miyashita ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Microrna Expression ◽  
Sensitive Detection ◽  
Circulating Microrna ◽  
Melanoma Metastasis

scholarly journals Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions

2014 ◽  
Vol 46 (11) ◽  
pp. 942-949 ◽  
Author(s):  
Yongming Xu ◽  
Xin Zhang ◽  
Shaofeng Pu ◽  
Junzhen Wu ◽  
Yingying Lv ◽  
...  
Keyword(s):  
Expression Profile ◽  
Microrna Expression ◽  
Circulating Microrna ◽  
Potential Predictor ◽  
Microrna Expression Profile

scholarly journals Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e106318 ◽  
Author(s):  
Dong Li ◽  
Long Ji ◽  
Lianbo Liu ◽  
Yizhi Liu ◽  
Haifeng Hou ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Septal Defect ◽  
Microrna Expression ◽  
Circulating Microrna

scholarly journals Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jun Wang ◽  
Jin-Tai Yu ◽  
Lin Tan ◽  
Yan Tian ◽  
Jing Ma ◽  
...  
Keyword(s):  
Expression Profiling ◽  
Microrna Expression ◽  
Circulating Microrna ◽  
Genome Wide

Circulating microRNA expression profiles in pre-eclampsia: evidence of increased miR-885-5p levels

2016 ◽  
Vol 123 (13) ◽  
pp. 2120-2128 ◽  
Author(s):  
VC Sandrim ◽  
MR Luizon ◽  
AC Palei ◽  
JE Tanus-Santos ◽  
RC Cavalli
Keyword(s):  
Expression Profiles ◽  
Microrna Expression ◽  
Circulating Microrna
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