Sensitive detection of melanoma metastasis using circulating microRNA expression profiles

2013 ◽  
Vol 23 (5) ◽  
pp. 366-372 ◽  
Author(s):  
Rie Shiiyama ◽  
Satoshi Fukushima ◽  
Masatoshi Jinnin ◽  
Junji Yamashita ◽  
Azusa Miyashita ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Microrna Expression ◽  
Sensitive Detection ◽  
Circulating Microrna ◽  
Melanoma Metastasis

Circulating microRNA expression profiles in pre-eclampsia: evidence of increased miR-885-5p levels

2016 ◽  
Vol 123 (13) ◽  
pp. 2120-2128 ◽  
Author(s):  
VC Sandrim ◽  
MR Luizon ◽  
AC Palei ◽  
JE Tanus-Santos ◽  
RC Cavalli
Keyword(s):  
Expression Profiles ◽  
Microrna Expression ◽  
Circulating Microrna

scholarly journals Circulating MicroRNA Expression Profiles in Patients with Stable and Unstable Angina

Clinics ◽  
2020 ◽  
Vol 75 ◽  
Author(s):  
Sudong Liu ◽  
Xuemin Guo ◽  
Wei Zhong ◽  
Ruiqiang Weng ◽  
Jing Liu ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Circulating Microrna

Circulating microRNA expression profiles in ovarian cancer

2014 ◽  
Vol 34 (7) ◽  
pp. 620-624 ◽  
Author(s):  
L. Ayaz ◽  
F. Çayan ◽  
Ş. Balci ◽  
A. Görür ◽  
S. Akbayir ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Circulating Microrna

scholarly journals Circulating MicroRNA Expression Profiles Associated With Systemic Lupus Erythematosus

2013 ◽  
Vol 65 (5) ◽  
pp. 1324-1334 ◽  
Author(s):  
Anting Liu Carlsen ◽  
Aaron J. Schetter ◽  
Christoffer T. Nielsen ◽  
Christian Lood ◽  
Steen Knudsen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Circulating Microrna ◽  
Systemic Lupus

MicroRNAs and Adrenocortical Tumors: Where do we Stand on Primary Aldosteronism?

2020 ◽  
Vol 52 (06) ◽  
pp. 394-403
Author(s):  
Zsófia Tömböl ◽  
Péter István Turai ◽  
Ábel Decmann ◽  
Peter Igaz
Keyword(s):  
Rna Interference ◽  
Primary Aldosteronism ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Circulating Microrna ◽  
Adrenal Hyperplasia ◽  
Aldosterone Secretion ◽  
Adrenocortical Tumors ◽  
Bilateral Adrenal Hyperplasia ◽  
Aldosterone Producing Adenoma

AbstractMicroRNAs, the endogenous mediators of RNA interference, interact with the renin-angiotensin-aldosterone system, regulate aldosterone secretion and aldosterone effects. Some novel data show that the expression of some microRNAs is altered in primary aldosteronism, and some of these appear to have pathogenic relevance, as well. Differences in the circulating microRNA expression profiles between the two major forms of primary aldosteronism, unilateral aldosterone-producing adenoma and bilateral adrenal hyperplasia have also been shown. Here, we present a brief synopsis of these findings focusing on the potential relevance of microRNA in primary aldosteronism.

506. MENSTRUAL CYCLE VARIATIONS IN PLASMA microRNA EXPRESSION PROFILES

2009 ◽  
Vol 21 (9) ◽  
pp. 106
Author(s):  
E. M. C. Ohlsson Teague ◽  
V. Nisenblat ◽  
S. A. Robertson ◽  
M. L. Hull
Keyword(s):  
Menstrual Cycle ◽  
Diagnostic Tests ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Cycle Phase ◽  
Circulating Microrna ◽  
Transcriptional Level ◽  
Secretory Phase ◽  
Plasma Microrna ◽  
Reproductive Aged Women

microRNAs are short, single-stranded RNAs that regulate gene expression at the post-transcriptional level. Plasma and serum microRNAs correlate closely with microRNA profiles of diseased tissue and have been explored as blood-based biomarkers for human diseases, including steroid-driven malignancies. However, reproductive steroid signalling regulates the expression of specific microRNAs and this could impact the utility of microRNA biomarkers in reproductive aged women. We hypothesised that microRNA expression profiles are altered by steroid hormone fluctuations associated with the menstrual cycle. To test this hypothesis, plasma microRNA expression was measured in healthy women at 3 stages of a 28 day menstrual cycle; ie menstrual (day 3-5), follicular (day 9–13) and implantation window/secretory phase (day 18–22). Total RNA was extracted from plasma, multiplex reverse transcription was performed, and the cDNA pre-amplified prior to expression analysis of 667 microRNAs on Taqman low density PCR arrays (n=6 women). Preliminary data shows that up to 200 microRNAs may be detected with this methodology, and that at least 14 of these are differentially expressed (fold change ≥±1.5) at follicular and secretory phase, as compared to menstrual phase. We plan to confirm these findings with standard Taqman microRNA assays (n=10 women). Our findings suggest that plasma miRNA expression profiles change over the menstrual cycle, and that this could confound microRNA-based diagnostic tests. We hope to demonstrate the most appropriate cycle phase for blood-based miRNA profiling, facilitating the development of plasma microRNA-based diagnostic tests and providing valuable information to researchers studying circulating microRNA profiles in reproductive aged women.

Effects of dexamethasone and adrenocorticotropin on circulating microRNA expression in humans

2015 ◽  
Author(s):  
Ivan Igaz ◽  
Gabor Nyiro ◽  
Zoltan Nagy ◽  
Pal Perge ◽  
Miklos Toth ◽  
...  
Keyword(s):  
Microrna Expression ◽  
Circulating Microrna

scholarly journals Analysis of Circulating microRNA Signatures and Preeclampsia Development

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1003
Author(s):  
Margarita L. Martinez-Fierro ◽  
Idalia Garza-Veloz
Keyword(s):  
Pregnant Women ◽  
Expression Profiling ◽  
Gene Prediction ◽  
Microrna Expression ◽  
Differentially Expressed ◽  
Control Group ◽  
Case Group ◽  
Circulating Microrna ◽  
Activated T Cells ◽  
Serum Microrna

microRNAs are important regulators of cell processes and have been proposed as potential preeclampsia biomarkers. We evaluated serum microRNA expression profiling to identify microRNAs involved in preeclampsia development. Serum microRNA expression profiling was evaluated at 12, 16, and 20 weeks of gestation (WG), and at the time of preeclampsia diagnosis. Two groups were evaluated using TaqMan low-density array plates: a control group with 18 normotensive pregnant women and a case group with 16 patients who developed preeclampsia during the follow-up period. Fifty-three circulating microRNAs were differentially expressed between groups (p < 0.05). Compared with controls, hsa-miR-628-3p showed the highest relative quantity values (at 12 WG = 7.7 and at 20 WG = 3.45) and the hsa-miRs -151a-3p and -573 remained differentially expressed from 16 to 20 WG (p < 0.05). Signaling pathways including cancer-related, axon guidance, Neurotrophin, GnRH, VEGF, and B/T cell receptor, were most commonly altered. Further target gene prediction revealed that nuclear factor of activated T-cells 5 gene was included among the transcriptional targets of preeclampsia-modulated microRNAs. Specific microRNAs including hsa-miRs -628-3p, -151a-3p, and -573 were differentially expressed in serum of pregnant women before they developed preeclampsia compared with controls and their participation in the preeclampsia development should be considered.

scholarly journals Identification of Tumorigenic and Prognostic Biomarkers in Colorectal Cancer Based on microRNA Expression Profiles

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yuntao Shi ◽  
Yingying Zhuang ◽  
Jialing Zhang ◽  
Mengxue Chen ◽  
Shangnong Wu
Keyword(s):  
Target Genes ◽  
Cox Regression ◽  
Expression Profiles ◽  
Survival Rates ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Risk Groups ◽  
Normal Mucosa ◽  
Microrna Expression ◽  
Functional Enrichment

Objective. Although noncoding RNAs, especially the microRNAs, have been found to play key roles in CRC development in intestinal tissue, the specific mechanism of these microRNAs has not been fully understood. Methods. GEO and TCGA database were used to explore the microRNA expression profiles of normal mucosa, adenoma, and carcinoma. And the differential expression genes were selected. Computationally, we built the SVM model and multivariable Cox regression model to evaluate the performance of tumorigenic microRNAs in discriminating the adenomas from normal tissues and risk prediction. Results. In this study, we identified 20 miRNA biomarkers dysregulated in the colon adenomas. The functional enrichment analysis showed that MAPK activity and MAPK cascade were highly enriched by these tumorigenic microRNAs. We also investigated the target genes of the tumorigenic microRNAs. Eleven genes, including PIGF, TPI1, KLF4, RARS, PCBP2, EIF5A, HK2, RAVER2, HMGN1, MAPK6, and NDUFA2, were identified to be frequently targeted by the tumorigenic microRNAs. The high AUC value and distinct overall survival rates between the two risk groups suggested that these tumorigenic microRNAs had the potential of diagnostic and prognostic value in CRC. Conclusions. The present study revealed possible mechanisms and pathways that may contribute to tumorigenesis of CRC, which could not only be used as CRC early detection biomarkers, but also be useful for tumorigenesis mechanism studies.

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