Modulating effects of omega-3 fatty acids and pioglitazone combination on insulin resistance through toll-like receptor 4 in type 2 diabetes mellitus

2016 ◽  
Author(s):  
Laila Eissa ◽  
Salma Eraky ◽  
Noha Mansour
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Omega 3 Fatty Acids ◽  
Toll Like Receptor ◽  
Omega 3 ◽  
Toll Like Receptor 4

scholarly journals The correlation between serum resistin and toll-like receptor-4 with insulin resistance in hypertensive subjects with or without type 2 diabetes mellitus

2021 ◽  
Vol 2 (04) ◽  
pp. 203-217
Author(s):  
Mustafa Al-Taie ◽  
Rayah Baban ◽  
Mouayed Hamed
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Hypertensive Patients ◽  
Patient Groups

Background: The most chronic disease prevalence in the Iraqi population are type-2 diabetes mellitus (T2DM) and hypertension (HT). One of the important causes of these chronic diseases is obesity. Resistin (RETN) is a major link between obesity and insulin resistance (IR) or T2DM (which induces IR). The action of RETN on IR is mediated by Toll-like receptor-4 (TLR4). TLR4 is a putative RETN receptor that has been suggested to participate in RETN-inducing inflammation and IR. Objectives: To study the association between serum RETN/TLR4 and IR in hypertensive patients with or without T2DM subjects. Methods: This cross-sectional study was conducted on 120 men that classified into four different groups. These groups consist of the following: 30 apparently control group, 30 patients with hypertension, 30 patients with T2DM but without HT and 30 hypertensive patients with T2DM. For all the subjects, serum RETN, TLR4 and serum insulin was estimated by using the ELISA technique. Results: Our results showed that mean levels of the serum RETN and TLR4 were significantly elevated in all patient groups when compared with the control group. Also, a positive correlation between serum RETN and TLR4 was found in hypertensive patients with T2DM patients. Conclusions: Serum RETN and TLR4 were higher in all patient groups when compared with the control group. In addition, a positive correlation between RETN and IR in all study groups was noted. Then, we suggested a close association between RETN and TLR4 and their positive correlations with IR.

scholarly journals Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus

2009 ◽  
Vol 90 (3) ◽  
pp. 613-620 ◽  
Author(s):  
Manas Kaushik ◽  
Dariush Mozaffarian ◽  
Donna Spiegelman ◽  
JoAnn E Manson ◽  
Walter C Willett ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Fish Intake ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain
Sign in / Sign up

Export Citation Format

Share Document