Growth hormone signaling and action in obese versus lean human subjects: evidence of increased hepatic GH sensitivity in obesity

2017 ◽  
Author(s):  
Morten Hogild Pedersen ◽  
Ann Mosegaard Bak ◽  
Steen Bonlokke Pedersen ◽  
Niels Jessen ◽  
Niels Moller ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Subjects ◽  
Hormone Signaling

OR13,1 The impact of fasting on growth hormone signaling and action in muscle and fat tissue in human subjects

2008 ◽  
Vol 18 ◽  
pp. S25
Author(s):  
L. Moller ◽  
L. Dalman ◽  
H. Norrelund ◽  
J. Frystyk ◽  
N. Billestrup ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Subjects ◽  
Hormone Signaling ◽  
Fat Tissue ◽  
The Impact

scholarly journals Growth Hormone Signaling in Muscle and Adipose Tissue of Obese Human Subjects: Associations With Measures of Body Composition and Interaction With Resveratrol Treatment

2014 ◽  
Vol 99 (12) ◽  
pp. E2565-E2573 ◽  
Author(s):  
Berthil F. Clasen ◽  
Morten M. Poulsen ◽  
Carlos Escande ◽  
Steen B. Pedersen ◽  
Niels Møller ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Adipose Tissue ◽  
Human Subjects ◽  
Hormone Signaling ◽  
Resveratrol Treatment ◽  
Obese Human

scholarly journals Obesity and its impact on COVID-19

2021 ◽  
Author(s):  
Angélica J. M. de Leeuw ◽  
Maureen A. M. Oude Luttikhuis ◽  
Annemarijn C. Wellen ◽  
Christine Müller ◽  
Cornelis F. Calkhoven
Keyword(s):  
Risk Factors ◽  
Growth Hormone ◽  
Healthcare Systems ◽  
Review Literature ◽  
Overweight And Obesity ◽  
Hormone Signaling ◽  
Global Spread ◽  
Number Of Publications ◽  
The Impact ◽  
Sheer Number

AbstractThe severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.

METABOLIC EFFECTS OF “PITUITARY GROWTH HORMONE PREPARATIONS” IN HUMAN SUBJECTS SUMMARY OF QUANTITATIVE STUDIES EXTENDING OVER A FIVE-YEAR PERIOD

1954 ◽  
Vol 14 (1) ◽  
pp. 110-117 ◽  
Author(s):  
LAURANCE W. KINSELL ◽  
SHELDON MARGEN ◽  
JOHN W. PARTRIDGE ◽  
GEORGE D. MICHAELS ◽  
HARRY E. BALCH ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Subjects ◽  
Metabolic Effects ◽  
Pituitary Growth Hormone ◽  
Quantitative Studies

scholarly journals Growth hormone signaling and action in obese versus lean human subjects

2019 ◽  
Vol 316 (2) ◽  
pp. E333-E344 ◽  
Author(s):  
Morten Lyng Høgild ◽  
Ann Mosegaard Bak ◽  
Steen Bønløkke Pedersen ◽  
Jørgen Rungby ◽  
Jan Frystyk ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Growth Hormone ◽  
Human Subjects ◽  
Glucose Production ◽  
Relative Increase ◽  
Antagonistic Effect ◽  
Endogenous Glucose Production ◽  
Metabolic Adaptation ◽  
Igf I

Growth hormone (GH) levels are blunted in obesity, but it is not known whether this relates to altered GH sensitivity and whether this influences the metabolic adaptation to fasting. Therefore, we investigated the effect of obesity on GH signal transduction and fasting-induced changes in GH action. Nine obese (BMI 35.7 kg/m2) and nine lean (BMI 21.5 kg/m2) men were studied in a randomized crossover design with 1) an intravenous GH bolus, 2) an intravenous saline bolus, and 3) 72 h of fasting. Insulin sensitivity (hyperinsulinemic, euglycemic clamp) and substrate metabolism (glucose tracer and indirect calorimetry) were measured in studies 1 and 2. In vivo GH signaling was assessed in muscle and fat biopsies. GH pharmacokinetics did not differ between obese and lean subjects, but endogenous GH levels were reduced in obesity. GH signaling (STAT5b phosphorylation and CISH mRNA transcription), and GH action (induction of lipolysis and peripheral insulin resistance) were similar in the two groups, but a GH-induced insulin antagonistic effect on endogenous glucose production only occurred in the obese. Fasting-induced IGF-I reduction was completely abrogated in obese subjects despite a comparable relative increase in GH levels (ΔIGF-I: lean, −66 ± 10 vs. obese, 27 ± 16 µg/l; P < 0.01; ΔGH: lean, 647 ± 280 vs. obese, 544 ± 220%; P = 0.76]. We conclude that 1) GH signaling is normal in obesity, 2) in the obese state, the preservation of IGF-I with fasting and the augmented GH-induced central insulin resistance indicate increased hepatic GH sensitivity, 3) blunted GH levels in obesity may protect against insulin resistance without compromising IGF-I status.

17β-Estradiol positively modulates growth hormone signaling through the reduction of SOCS2 negative feedback in human osteoblasts

Bone ◽  
2013 ◽  
Vol 55 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Simona Bolamperti ◽  
Emanuela Mrak ◽  
GianLuigi Moro ◽  
Paolo Sirtori ◽  
Gianfranco Fraschini ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Negative Feedback ◽  
Hormone Signaling ◽  
Human Osteoblasts ◽  
17Β Estradiol

Role of Prolactin Receptor in Growth Hormone Signaling in Human Breast Cancer Cells.

2010 ◽  
pp. OR33-6-OR33-6
Author(s):  
Jie Xu ◽  
Jing Jiang ◽  
Peter E Lobie ◽  
Serge Y Fuchs ◽  
Stuart J Frank
Keyword(s):  
Breast Cancer ◽  
Growth Hormone ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Prolactin Receptor ◽  
Hormone Signaling ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Growth Hormone Signaling in the Regulation of Acid Labile Subunit

2008 ◽  
Vol 21 (5) ◽  
pp. 754-768 ◽  
Author(s):  
Jin Wook Kim ◽  
Yves R. Boisclair
Keyword(s):  
Growth Hormone ◽  
Hormone Signaling ◽  
Acid Labile Subunit ◽  
Acid Labile
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