Contribution of retinoic acid receptor signalling to adrenal cortex morphology and functional zonation through modulation of WNT/[beta]-catenin pathway

2017 ◽  
Author(s):  
Zein Rami El ◽  
Amanda J Rickard ◽  
Golib Dzib Jose Felipe ◽  
Benoit Samson-Couterie ◽  
Angelique Rocha ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Beta Catenin ◽  
Acid Receptor ◽  
Receptor Signalling

scholarly journals Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Rami M. El Zein ◽  
Audrey H. Soria ◽  
Jose Felipe Golib Dzib ◽  
Amanda J. Rickard ◽  
Fabio L. Fernandes-Rosa ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Retinoic Acid ◽  
Wnt Signaling ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Structure And Function ◽  
Acid Receptor ◽  
And Function ◽  
Canonical Wnt

Abstract Primary aldosteronism (PA) is the most frequent form of secondary arterial hypertension. Mutations in different genes increase aldosterone production in PA, but additional mechanisms may contribute to increased cell proliferation and aldosterone producing adenoma (APA) development. We performed transcriptome analysis in APA and identified retinoic acid receptor alpha (RARα) signaling as a central molecular network involved in nodule formation. To understand how RARα modulates adrenal structure and function, we explored the adrenal phenotype of male and female Rarα knockout mice. Inactivation of Rarα in mice led to significant structural disorganization of the adrenal cortex in both sexes, with increased adrenal cortex size in female mice and increased cell proliferation in males. Abnormalities of vessel architecture and extracellular matrix were due to decreased Vegfa expression and modifications in extracellular matrix components. On the molecular level, Rarα inactivation leads to inhibition of non-canonical Wnt signaling, without affecting the canonical Wnt pathway nor PKA signaling. Our study suggests that Rarα contributes to the maintenance of normal adrenal cortex structure and cell proliferation, by modulating Wnt signaling. Dysregulation of this interaction may contribute to abnormal cell proliferation, creating a propitious environment for the emergence of specific driver mutations in PA.

scholarly journals The endogenous retinoid metaboliteS-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling bothin vitroandin vivo

FEBS Journal ◽  
2009 ◽  
Vol 276 (11) ◽  
pp. 3043-3059 ◽  
Author(s):  
Jan P. Schuchardt ◽  
David Wahlström ◽  
Joëlle Rüegg ◽  
Norbert Giese ◽  
Madalina Stefan ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Receptor Signalling

[OP.3A.02] RETINOIC ACID RECEPTOR SIGNALING CONTRIBUTES TO ADRENAL CORTEX MORPHOLOGY AND FUNCTIONAL ZONATION

2016 ◽  
Vol 34 ◽  
pp. e26
Author(s):  
S. Boulkroun ◽  
A. Rickard ◽  
J. Golib Dzib ◽  
B. Samson-couterie ◽  
A. Rocha ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Receptor Signaling ◽  
Acid Receptor

scholarly journals SAT-LB061 Sex-Specific Role of Retinoic Acid Receptor Alpha Signaling in Adrenal Cortex Development and Functional Zonation

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Rami EL ZEIN ◽  
Audrey Soria ◽  
Jose Felipe Golib Dzib ◽  
Amanda Rickard ◽  
Fabio Luiz Fernandes-Rosa ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adrenal Cortex ◽  
Retinoic Acid Receptor ◽  
Specific Role ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Receptor ◽  
Receptor Alpha

Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells

2017 ◽  
Vol 350 (1) ◽  
pp. 284-297 ◽  
Author(s):  
A.C. Green ◽  
P. Kocovski ◽  
T. Jovic ◽  
M.K. Walia ◽  
R.A.S. Chandraratna ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Progenitor Cells ◽  
Adipocyte Differentiation ◽  
Retinoic Acid Receptor ◽  
Mesenchymal Progenitor Cells ◽  
Acid Receptor ◽  
Receptor Signalling
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