The role of estimated glucose disposal rate as a predictor of insulin resistance, NAFLD and major adverse cardiovascular events in type 1 diabetes mellitus

2021 ◽  
Author(s):  
Jonathan Mertens ◽  
Christophe De Block ◽  
Eveline Dirinck ◽  
Sven Francque
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Cardiovascular Events ◽  
Glucose Disposal ◽  
Major Adverse Cardiovascular Events ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

scholarly journals Estimated Glucose Disposal Rate (eGDR) – A Marker for the Assessment of Insulin Resistance in Type 1 Diabetes Mellitus

2016 ◽  
Vol 23 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Mihaela L. Bîcu ◽  
Daniel Bîcu ◽  
Sigina Gârgavu ◽  
Magdalena Sandu ◽  
Mihaela I. Vladu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Disposal ◽  
Chronic Complications ◽  
Important Indicator ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

AbstractBackground and Aims: Studies have shown an increased incidence of chronic complications in people with type 1 diabetes mellitus (T1DM) with insulin resistance (IR) compared to people with T1DM without IR. Estimated glucose disposal rate (eGDR) is an important indicator of IR in patients with T1DM, lower eGDR levels indicating greater IR. It was shown that T1DM patients with chronic complications (diabetic retinopathy - DR, diabetic peripheral neuropathy - DPN or diabetic kidney disease - DKD) exhibit higher IR compared to patients without chronic complications. The aim of our study was to evaluate eGDR as a marker for the assessment of IR in T1DM patients.Materials and Methods: The study was observational, cross-sectional and included 140 T1DM patients with diabetes duration>10 years. The collected data were analyzed using the Statistic Package for Social Sciences (SPSS) version 22 software (IBM Corporation, Armonk, NY, USA).Results: eGDR presented statistically significant correlations (p<0.05) with the presence of metabolic syndrome (MS), obesity, chronic complications of T1DM, cardiovascular risk (CVR) and smoking status in patients with T1DM duration >10 years.Conclusions: eGDR represents a reliable marker for assessing the IR in T1DM.

scholarly journals Estimated glucose disposal rate demographics and clinical characteristics of young adults with type 1 diabetes mellitus: A cross-sectional pilot study

2020 ◽  
Vol 17 (5) ◽  
pp. 147916412095232
Author(s):  
Revathi Nishtala ◽  
Noppadol Kietsiriroje ◽  
Mohammad Karam ◽  
Ramzi A Ajjan ◽  
Sam Pearson
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Characteristics ◽  
Glucose Disposal ◽  
Cross Sectional ◽  
Lipid Management ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

Background: Estimated glucose disposal rate (eGDR) is a practical measure of Insulin Resistance (IR) which can be easily incorporated into clinical practice. We profiled eGDR in younger adults with type 1 diabetes mellitus (T1DM) by their demographic and clinical characteristics. Methods: In this single centre study, medical records of TIDM were assessed and eGDR tertiles correlated with demographic and clinical variables. Results: Of 175 T1DM individuals, 108 (61.7%) were males. Mean age (±SD) was 22.0 ± 1.6 years and median time from diagnosis 11.0 years (range 1–23). Individuals were predominantly Caucasian (81.7%), with 27.4% being overweight (BMI: 25–30 kg/m2) and 13.7% obese (BMI > 30 kg/m2). Mean total cholesterol (TC) levels were significantly lower in high and middle eGDR tertiles (4.4 ± 1 and 4.3 ± 0.8 mmol/l, respectively) compared with low eGDR tertile (4.8 ± 1, p < 0.05 for both). Triglyceride (TG) levels showed a similar trend at 1.1 ± 0.5 and 1.1 ± 0.5 mmol/l for high and middle eGDR tertile compared to low eGDR tertile (1.5 ± 1 mmol/l, p < 0.05 for both). Renal function was similar across eGDR tertiles and no difference in retinopathy was detected. Conclusion: TC and TG are altered in individuals with T1DM and low eGDR, suggesting that this subgroup requires optimal lipid management to ameliorate their vascular risk.

Estimated glucose disposal rate in patients under 18 years of age with type 1 diabetes mellitus and overweight or obesity

2013 ◽  
Vol 60 (7) ◽  
pp. 379-385
Author(s):  
Enrique Palomo Atance ◽  
M. José Ballester Herrera ◽  
Patricio Giralt Muiña ◽  
Rafael Ruiz Cano ◽  
Alberto León Martín ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Disposal ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate ◽  
Overweight Or Obesity

scholarly journals Use of the Estimated Glucose Disposal Rate as a Measure of Insulin Resistance in an Urban Multiethnic Population With Type 1 Diabetes

Diabetes Care ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. 2280-2285 ◽  
Author(s):  
E. J. Epstein ◽  
J. L. Osman ◽  
H. W. Cohen ◽  
S. N. Rajpathak ◽  
O. Lewis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Glucose Disposal ◽  
Multiethnic Population ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

Estimated Glucose Disposal Rate as a Predictor of All-Cause Mortality in Type 1 Diabetes—A 10-Year Follow-Up Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1694-P
Author(s):  
MONIA GAROFOLO ◽  
ALESSANDRA BERTOLOTTO ◽  
FABRIZIO CAMPI ◽  
DANIELA LUCCHESI ◽  
LAURA GIUSTI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Disposal ◽  
Follow Up Study ◽  
All Cause Mortality ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

scholarly journals Association of estimated glucose disposal rate and chronic diabetic complications in patients with type 1 diabetes

2021 ◽  
Author(s):  
César Ernesto Lam‐Chung ◽  
Néstor Martínez Zavala ◽  
Raúl Ibarra‐Salce ◽  
Francisco Javier Pozos Varela ◽  
Tania S. Mena Ureta ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Complications ◽  
Glucose Disposal ◽  
Estimated Glucose Disposal Rate ◽  
Glucose Disposal Rate

The role of myokines in the development of insulin resistance in children, with type 1 diabetes mellitus

2021 ◽  
pp. 19-26
Author(s):  
O. Ye. Pashkova ◽  
N. I. Chudova ◽  
O. S. Litvinenko
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Muscle Strength ◽  
Blood Serum ◽  
Muscle Mass ◽  
Pediatric Patients ◽  
Control Group

The aim — to study the role of myokines in the development of insulin resistance in children with type 1 diabetes mellitus.Materials and methods. Observations involved 68 children with type 1 diabetes mellitus (DM 1), with the mean age 11 to 17 years. Depending on the glycemic controllevel, patients were divided into 3 research groups. The control group consisted of 20 relatively healthy children. Muscle mass, the skeletal muscles index, fat mass and the percentage of fat in the bodywere determined in all patients. The Lovett’s test was used to assess the loss of muscle strength; evaluation of insulin resistance was made based onthe triglyceride­glucose index (TYG). Levels of myostatin, irisin, interleukins ­6 and ­13were measured in blood serum.Results and discussion. It has been established that with deterioration in the level of glycemic controlin DM 1 children, the component redistribution of body composition took place with an increased fat mass proportionand decreased muscle mass. This resulted in the reduced insulin-mediatedabsorption of glucose, that was confirmed by the significant increase in TYG level compared to control group. The analysis of cytokines in the blood serum showed a significant increase in the level of myostatin and interleukin­6 compared with the control group and the tendency to increased levels of the interleukins ­13 and the level of irisin in the blood serum in pediatric patients with DM 1. The increased levels of myostatin in DM 1childrenassociated with an increase in the triglycerides content (r = 0.44, p < 0.05) and raised TYG index (r = 0.33, p < 0.05), testifying theclose correlation between the high myostatin levels and the development of insulin resistance.Conclusions. In children with diabetes mellitus, the reduction of muscle strength and muscle mass take place with a deterioration in the state of glycemic control, accompanying by the development of insulin resistance. The violation of myokines synthesis,along with the chronic hyperglycemia and diabetic myopathy, plays the leading role in the formation of insulin resistance in pediatric patients with DM 1. It is manifested by the increased production of myostatin and interleukin­6 in the absence of activation of irisin and interleukin­13synthesis.

Sign in / Sign up

Export Citation Format

Share Document