Placental levels of miR-1-3p and miR-133a-3p are decreased in pregnancies complicated gestational diabetes with large-for-gestational-age birth outcomes and may be influencing vascular smooth muscle differentiation

2021 ◽  
Author(s):  
Margeurite Kennedy ◽  
Nigel Simpson ◽  
Eleanor Scott ◽  
Karen Forbes
Keyword(s):  
Smooth Muscle ◽  
Gestational Diabetes ◽  
Vascular Smooth Muscle ◽  
Birth Outcomes ◽  
Gestational Age ◽  
Muscle Differentiation ◽  
Large For Gestational Age ◽  
Smooth Muscle Differentiation

Vascular smooth muscle differentiation of murine stroma

1999 ◽  
Vol 27 (12) ◽  
pp. 1782-1795 ◽  
Author(s):  
Jean-Paul Remy-Martin ◽  
Aliette Marandin ◽  
Bruno Challier ◽  
Gabrielle Bernard ◽  
Marie Deschaseaux ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Differentiation ◽  
Smooth Muscle Differentiation

Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo

1998 ◽  
Vol 111 (19) ◽  
pp. 2977-2988 ◽  
Author(s):  
D.J. Grainger ◽  
J.C. Metcalfe ◽  
A.A. Grace ◽  
D.E. Mosedale
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Muscle Differentiation ◽  
Tgf Beta ◽  
Differentiation Markers ◽  
Smooth Muscle Tissue ◽  
Smooth Muscle Differentiation

Variations in the levels of smooth muscle-specific isoforms of contractile proteins have been reported to occur in many different vascular diseases. However, although much work has been done in vitro to investigate the regulation of smooth muscle cell differentiation, the molecular mechanisms which regulate the differentiation of vascular smooth muscle tissue in vivo are unknown. Using quantitative immunofluorescence, we show that in rat arteries levels of smooth muscle differentiation markers correlate with the levels of the cytokine TGF-beta. In young mice with one allele of the TGF-beta1 gene deleted, the levels of both TGF-beta1 and smooth muscle differentiation markers are reduced compared to wild-type controls. This regulation of smooth muscle differentiation by TGF-beta during post-natal development also occurs dynamically in the adult animal. Following various pharmacological or surgical interventions, including treatment of mice with tamoxifen and balloon injury of rat carotid arteries, there is a strong correlation between the changes in the levels of TGF-beta and changes in the levels of smooth muscle differentiation markers (r=0. 9, P<0.0001 for n=26 experiments). We conclude that TGF-beta dynamically regulates smooth muscle differentiation in rodent arteries in vivo.

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