Let's go beyond: The relationship between arterial stiffness and CGM-derived glycemic control in patients with type 1 diabetes

2021 ◽  
Author(s):  
Helleputte S. ◽  
Calders P. ◽  
Lapauw B. ◽  
De Backer T.
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Arterial Stiffness ◽  
The Relationship

scholarly journals Metabolic Control of the FreeStyle Libre System in the Pediatric Population with Type 1 Diabetes Dependent on Sensor Adherence

2022 ◽  
Vol 11 (2) ◽  
pp. 286
Author(s):  
Isabel Leiva-Gea ◽  
Maria F. Martos-Lirio ◽  
Ana Gómez-Perea ◽  
Ana-Belen Ariza-Jiménez ◽  
Leopoldo Tapia-Ceballos ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Metabolic Control ◽  
Pediatric Population ◽  
Interventional Study ◽  
Freestyle Libre ◽  
Scan Rate ◽  
The Impact ◽  
The Relationship

Aims: To evaluate the relationship between daily sensor scan rates and changes in HbA1c and hypoglycemia in children. Methods: We enrolled 145 paediatric T1D patients into a prospective, interventional study of the impact of the FreeStyle Libre 1 system on measures of glycemic control. Results: HbA1c was higher at lower scan rates, and decreased as the scan rate increased to 15–20 scans, after which it rose at higher scan rates. An analysis of the change in hypoglycemia, based on the number of daily sensor scans, showed there was a significant correlation between daily scan rates and hypoglycemia. Subjects with higher daily scan rates reduced all levels of hypoglycaemia. Conclusions: HbA1c is higher at lower scan rates, and decreases as scan rate increases. Reductions in hypoglycemia were evident in subjects with higher daily scan rates.

scholarly journals Effects of Treatment With Continuous Subcutaneous Insulin Infusion on Arterial Stiffness and Endothelial Glycocalyx Compared to MDI Intensification in Patients With Type 1 Diabetes: Improvement After a Six-Month Pump Treatment

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A458-A459
Author(s):  
Aikaterini Kountouri ◽  
John Thymis ◽  
Foteini Kousathana ◽  
Konstantinos Balampanis ◽  
Loukia Pliouta ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Arterial Stiffness ◽  
Vascular Function ◽  
Continuous Subcutaneous Insulin Infusion ◽  
Insulin Infusion ◽  
Endothelial Glycocalyx ◽  
Control Group ◽  
Subcutaneous Insulin

Abstract Patients with type 1 diabetes mellitus (T1DM) present signs of atherosclerosis and endothelial dysfunction earlier compared to healthy individuals. The evidence regarding the efficacy of continuous subcutaneous insulin infusion (CSII) in vascular function in T1DM are scarce. The aim of this study is to determine whether insulin intensification with CSII improves arterial stiffness and endothelial function in T1DM compared to multiple daily insulin (MDI) injections. Thirty patients with T1DM were included in our study. Fifteen patients with poor glycemic control were transitioned from MDI to CSII and were reviewed immediately prior (baseline) and six months after the initiation of CSII. Fifteen patients, matched for sex, age and glycemic control, remained on intensified treatment with MDI (control group). In all patients at each visit we measure a) Carotid-femoral PWV b) central systolic blood pressure (cSBP) c) perfused boundary region (PBR) of the sublingual arterial microvessels. Both groups had similar cardiovascular markers and HbA1c at baseline (p>0.05). After a six month treatment period, patients on CSII improved HbA1c (7.9±1.5% vs 7.35±0.7%, p<0.05), PBR (2.1±0.2 vs. 2±0.2 μm, p<0.05), PWV (7.5±0.3 vs. 7.4±1.1m/s, p<0,05) and cSBP (114.6±12.5 vs. 112±5.4 mmHg, p<0.05). There were no statistically significant differences in PBR (2±0.3 vs. 2±0.3 μm, p>0.05), PWV (8±2.3 vs. 8±1.9m/s, p>0.05) and cSBP (115±15.2 vs. 115.7±15.4 mmHg, p>0.05) in patients who remained on MDI, despite improvement of HbA1c (8±1.1% vs 7.36±0.8%, p<0.05). The use of CSII improves the thickness of endothelial glycocalyx and decreases arterial stiffness after six months treatment in patients with T1DM.

The relationship of glycemic control, insulin dose, and race with hypoglycemia in youth with type 1 diabetes

2020 ◽  
Vol 34 (6) ◽  
pp. 107519
Author(s):  
Stuart Chalew ◽  
Jodi Kamps ◽  
Brittney Jurgen ◽  
Ricardo Gomez ◽  
James Hempe
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Insulin Dose ◽  
Relationship Of ◽  
The Relationship

scholarly journals Characteristics of depressiveness among adolescents with diabetes mellitus

Medicina ◽  
2006 ◽  
Vol 43 (1) ◽  
pp. 65
Author(s):  
Jolanta Žilinskienė ◽  
Liuda Šinkariova ◽  
Aidas Perminas
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Depressed Mood ◽  
Daily Activity ◽  
Depression Scale ◽  
Negative Attitude ◽  
The Relationship

The objective of this article was to establish the characteristics of depressiveness among adolescents with diabetes. Adolescents aged 14 and 16 years suffering from diabetes, healthy ones, and their parents were enrolled in the study. A total of 260 adolescents (100 adolescents with type 1 diabetes mellitus and 160 healthy ones) were interviewed. To measure adolescents’ depressiveness, a new scale was constructed using different questionnaires (Maastricht, Hamilton, Beck). Parents’ depressiveness was measured with Beck depression scale. This study showed that 16-year-old girls with diabetes were more depressed than the healthy ones. Mothers of 14-year-old adolescents and 16-year-old girls with diabetes are more depressed than the healthy adolescents’ mothers. Results of the study confirmed that depressiveness of 14- and 16-year-old girls with diabetes and that of their mothers were related. The relationship between the depressiveness of mothers of 14-year-old boys with diabetes mellitus and bad glycemic control of their sons was determined. The following peculiarities of depressiveness among adolescents with diabetes were found: 14-year-old girls had more negative attitude toward themselves; 16-year-old girls were very sensitive and had depressed mood; 16-year-old boys complained about lowered daily activity.

scholarly journals Continuous Glucose Monitoring in People With Type 1 Diabetes on Multiple-Dose Injection Therapy: The Relationship Between Glycemic Control and Hypoglycemia

Diabetes Care ◽  
2019 ◽  
Vol 43 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Nick Oliver ◽  
Marga Gimenez ◽  
Peter Calhoun ◽  
Nathan Cohen ◽  
Vanessa Moscardo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Continuous Glucose Monitoring ◽  
Multiple Dose ◽  
Glucose Monitoring ◽  
Injection Therapy ◽  
The Relationship ◽  
Dose Injection
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