Association of insulin pump therapy vs insulin injection therapy with severe hypoglycemia, ketoacidosis, and glycemic control among children, adolescents, and young adults with T1DM

2018 ◽  
Author(s):  
Karges B ◽  
Schwandt A ◽  
Heidtmann B ◽  
Kordonouri O ◽  
Binder E ◽  
...  
Keyword(s):  
Young Adults ◽  
Glycemic Control ◽  
Insulin Pump ◽  
Severe Hypoglycemia ◽  
Insulin Injection ◽  
Injection Therapy ◽  
Adolescents And Young Adults ◽  
Insulin Pump Therapy ◽  
Pump Therapy

Complications With Insulin Pump Therapy vs Insulin Injection Therapy—Reply

JAMA ◽  
2018 ◽  
Vol 319 (5) ◽  
pp. 503
Author(s):  
Beate Karges ◽  
Elisabeth Binder ◽  
Joachim Rosenbauer
Keyword(s):  
Insulin Pump ◽  
Insulin Injection ◽  
Injection Therapy ◽  
Insulin Pump Therapy ◽  
Pump Therapy

scholarly journals Prospective study of efficacy and safety of insulin pump therapy in children and adolescents

2010 ◽  
Vol 13 (3) ◽  
pp. 143-146 ◽  
Author(s):  
Andrey Olegovich Emel'yanov ◽  
Tamara Leonidovna Kuraeva ◽  
Dmitriy Nikitich Laptev ◽  
Valentina Alexandrovna Peterkova
Keyword(s):  
Glycemic Control ◽  
Children And Adolescents ◽  
Insulin Pump ◽  
Severe Hypoglycemia ◽  
Self Control ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Raising Awareness ◽  
One Year

Adequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the most efficacious tool for the improvement of glycemic control.Aim. To estimate results of glycemic control in children and adolescents treated by insulin pump therapy. Materials and methods. The study included 173 patients aged 1.5-22 years having the disease for 0.5-20 years. MiniMed 508, MiniMed 712,MiniMed 722, Accu Check Spirit, Accu check D-Tron, Dana Care IIs pumps, ultrashort-acting insulins aspart and lispro were used. The patientsperformed self-control of glycemia 4-8 times during 24 hours. HbA1c was measured before and 12, 24, 36, 48 months after the onset of therapy. Thefrequency of DKA and severe hypoglycemia was recorded. Results. The HbA1c before the onset of therapy was 9.8 ?2.0% and dropped to 8.6; 8.7; 8.7; 8.9 and 9% 12, 24, 36, 48 months after it respectively.DKA was diagnosed in 20 (2.4%) and severe hypoglycemia in 5 patients. All patients in the CSII group were content with the use of the pumps, theabsence of injections and flexible day regimen. Conclusion. One year after the beginning of therapy the level of HbA1c significantly decreased. However, it increased again during a follow-up of5 years probably because of impaired compliance. This fact implies the necessity to regular repeat patient education for raising awareness of and motivationfor self-management.

Insulin Management for Type 1 Diabetic Patients During Social Alcohol Consumption: The SPRITZ Study

2020 ◽  
Vol 16 (6) ◽  
pp. 619-627
Author(s):  
Elisa Cipponeri ◽  
Cesare Blini ◽  
Christian Lamera ◽  
Valentina De Mori ◽  
Giovanni Veronesi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Glycemic Control ◽  
Educational Program ◽  
Insulin Pump ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Adult Type ◽  
Time To Peak

Background : There is no data available on the best insulin treatment to counteract the effects of glucose excursions due to a moderate alcohol intake associated with portions of slight fat and protein-containing food, as often the case during social happenings or “happy hours”. Introduction: This study analyzes the glycemic control and quality of life in 8 adult type 1 diabetic (T1D) patients on insulin-pump therapy which were invited to consume a traditional Italian aperitif (“Spritz” and chips). Introduction : This study analyzes the glycemic control and quality of life in 8 adult type 1 diabetic (T1D) patients on insulin-pump therapy which were invited to consume a traditional Italian aperitif (“Spritz” and chips). Methods: Patients consumed Spritz aperitif twice: using their habitual bolus, based on carbohydrates (CHO) counting (V1), or with a personalized, advanced bolus (V2) calculated from insulin/Kcal derived from Fats and Proteins (FPU). Post-prandial glucose was continuously monitored; glucose incremental areas (iAUC), glucose peak and time to peak, and estimated change from V1 to V2 from repeated- measures models were computed. Each patient fulfilled validated questionnaires on quality of life, knowledge about diabetes and CHO counting. Results : After the educational program, a reduced iAUC (0-80 min: -306, p=ns; 40-80 min: -400, p=0.07) due to greater (p=0.03) and prolonged double-wave insulin boluses was observed. Blood glucose peak and time to peak were also reduced. Moreover, improvements in the psycho-affective dimension, as well as in the alimentary knowledge were detected. Conclusion: Therefore, a personalized educational program on CHO + FPU counting together with insulin bolus management can improve glycemic control during social consumption of alcohol, with positive reflections on the psycho-affective dimension. Further studies are mandatory to confirm such preliminary results.

The effectiveness of a comprehensive diabetes program for glycemic control and adherence, and the selection of candidates for sensor-augmented insulin pump therapy

2021 ◽  
Vol 68 (10) ◽  
pp. 735-740
Author(s):  
José Fernando Botero ◽  
Luz Marcela Vásquez ◽  
Víctor M. Blanco ◽  
Diana Paola Cuesta ◽  
Alex Ramírez-Rincón ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Insulin Pump ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Selection Of

scholarly journals Glycemic Control and Hypoglycemia in Patients Treated with Insulin Pump Therapy: An Observational Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Guillermo Guzmán ◽  
Veline Martínez ◽  
Julián David Yara ◽  
Miguel Angel Mina ◽  
Juan Sebastian Solarte ◽  
...  
Keyword(s):  
Insulin Pump ◽  
Glycosylated Hemoglobin ◽  
Clinical Status ◽  
Life Quality ◽  
Glucose Monitoring ◽  
Severe Hypoglycemia ◽  
University Hospital ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Clinically Significant

Introduction. Diabetes mellitus (DM) is a highly prevalent disease worldwide. It has been associated with an important morbimortality due to its complications and sometimes as a result of adverse events related to treatment. Insulin pump therapy (IPT) is one of the options used to control this disease and reduces one of the most frequent complication associated with treatment: hypoglycemia, which has also a great impact on life quality and clinical status of patients. Materials and Methods. A descriptive and retrospective study was performed including patients treated and followed by the department of endocrinology from a high-complexity university hospital in Cali, Colombia, between 2012 and 2017. Patients were on IPT and continuous glucose monitoring (CGM): MiniMed Paradigm® Veo™ Insulin Pump (Medtronic®) and MiniMed 640G Insulin Pump-Enlite™ Sensor (Medtronic®). Presentation of hypoglycemia and variables associated with its development were evaluated. Results. 51 patients were included. The main indication for IPT initiation was the report of hypoglycemic episodes and inappropriate metabolic control. Initiation of IPT was related with a decrease in glycosylated hemoglobin (HbA1c) and also a decrease in severe hypoglycemic events and hospitalization due to hypoglycemia. The risk factors linked with clinically significant hypoglycemia were male gender, and standard deviation of glucose measures calculated by CGM. A diminished glomerular filtration rate (GFR) (<60 mL/min/1.73 m2) was correlated with higher risk of severe hypoglycemia. Conclusion. IPT with CGM is a useful strategy in the management of patients with DM; it is associated with a reduction of adverse hypoglycemic events and hospitalizations due to hypoglycemia.

Factors associated with glycemic control in adult type 1 diabetes patients treated with insulin pump therapy

Endocrine ◽  
2014 ◽  
Vol 48 (1) ◽  
pp. 164-169 ◽  
Author(s):  
Bartłomiej Matejko ◽  
Jan Skupien ◽  
Sandra Mrozińska ◽  
Małgorzata Grzanka ◽  
Katarzyna Cyganek ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Insulin Pump ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Adult Type ◽  
Factors Associated ◽  
Diabetes Patients
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