scholarly journals The potential roles of neurotrophins in male reproduction

Reproduction ◽  
2013 ◽  
Vol 145 (4) ◽  
pp. R89-R95 ◽  
Author(s):  
Chunjin Li ◽  
Xu Zhou
Keyword(s):  
Growth Factors ◽  
Cell Growth ◽  
Cell Types ◽  
Male Reproduction ◽  
Testicular Development ◽  
Cellular Distribution ◽  
Polypeptide Growth Factors ◽  
Growing Body ◽  
Neuronal Tissues ◽  
Existing Data

Neurotrophins are a family of polypeptide growth factors that are required for the proliferation, differentiation, survival, and death of neuronal cells. A growing body of evidence suggests that they may have broader physiological roles in various non-neuronal tissues. The testicles are complex non-neuronal organs in which diverse cell types interact to achieve correct spermatogenesis. Both neurotrophins and their receptors have been detected in various cell types from mammalian testes, suggesting that neurotrophins may regulate or mediate intercellular communication within this organ. This review summarizes the existing data on the cellular distribution and possible biological roles of neurotrophins in the testes. The data reported in the literature indicate that neurotrophins affect somatic cell growth and spermatogenesis and imply that they play a role in regulating testicular development and male reproduction.

A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor

1989 ◽  
Vol 9 (6) ◽  
pp. 2567-2573
Author(s):  
S Hartzell ◽  
K Ryder ◽  
A Lanahan ◽  
L F Lau ◽  
D Nathan
Keyword(s):  
Growth Factors ◽  
Cell Growth ◽  
Tissue Factor ◽  
Human Tissue ◽  
Blood Clotting ◽  
Transmembrane Protein ◽  
3T3 Cells ◽  
Proteolytic Activation ◽  
Polypeptide Growth Factors ◽  
Mediate Cell

Polypeptide growth factors rapidly induce the transcription of a set of genes that appear to mediate cell growth. We report that one of the genes induced in BALB/c mouse 3T3 cells encodes a transmembrane protein (mTF) homologous to human tissue factor, which is involved in the proteolytic activation of blood clotting. mTF mRNA is present in many murine tissues and cell lines. Our results raise the possibility that mTF may also play a role in cell growth.

Selective disruption of neuregulin-1 function in vertebrate embryos using ribozyme-tRNA transgenes

Development ◽  
1998 ◽  
Vol 125 (10) ◽  
pp. 1899-1907 ◽  
Author(s):  
J.J. Zhao ◽  
G. Lemke
Keyword(s):  
Growth Factors ◽  
Cell Types ◽  
Erbb Receptors ◽  
Retinal Ganglion ◽  
Hammerhead Ribozymes ◽  
Neuregulin 1 ◽  
Polypeptide Growth Factors ◽  
Developing Heart ◽  
The Central Nervous System

The products of the neuregulin-1 gene constitute a set of polypeptide growth factors whose signalling through the ErbB receptors is essential to the growth and differentiation of many cell types in culture. Although studies with neuregulin-1 mutant mice have demonstrated that these growth factors are also essential regulators of cellular differentiation in vivo, the mid-embryonic death of these mutants precludes an analysis of hypothesized neuregulin-1 roles in later aspects of development. To circumvent this early lethality, we have pursued a ribozyme-based strategy for the perturbation of neuregulin-1 function in developing chick embryos. Early administration of a retrovirus carrying neuregulin-1 hammerhead-type ribozymes to blastoderm-stage embryos leads to an embryonic lethal phenotype that results from the failure of ventricular trabeculation in the developing heart, a faithful phenocopy of the mouse neuregulin-1 mutations. Later, more localized delivery of the ribozyme to the developing retina inhibits both the differentiation of retinal ganglion cell neurons and the proliferation of the neuroepithelial cells from which they derive. These results suggest that neuregulin-1 promotes both muscle cell differentiation in the heart and neuronal differentiation in the central nervous system. In addition, they demonstrate the utility of hammerhead ribozymes as a simple, effective and easily adaptable method of conditional gene inactivation in vertebrates.

scholarly journals A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor.

1989 ◽  
Vol 9 (6) ◽  
pp. 2567-2573 ◽  
Author(s):  
S Hartzell ◽  
K Ryder ◽  
A Lanahan ◽  
L F Lau ◽  
D Nathan
Keyword(s):  
Growth Factors ◽  
Cell Growth ◽  
Tissue Factor ◽  
Human Tissue ◽  
Blood Clotting ◽  
Transmembrane Protein ◽  
3T3 Cells ◽  
Proteolytic Activation ◽  
Polypeptide Growth Factors ◽  
Mediate Cell

Polypeptide growth factors rapidly induce the transcription of a set of genes that appear to mediate cell growth. We report that one of the genes induced in BALB/c mouse 3T3 cells encodes a transmembrane protein (mTF) homologous to human tissue factor, which is involved in the proteolytic activation of blood clotting. mTF mRNA is present in many murine tissues and cell lines. Our results raise the possibility that mTF may also play a role in cell growth.

scholarly journals Exploring the Intracrine Functions of VEGF-A

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 128
Author(s):  
Sophie Wiszniak ◽  
Quenten Schwarz
Keyword(s):  
Cell Growth ◽  
Molecular Mechanisms ◽  
Direct Action ◽  
Cancer Therapeutics ◽  
Cell Types ◽  
Vascular Endothelial ◽  
Signalling Molecule ◽  
Endothelial Growth Factor ◽  
Important Signalling Molecule ◽  
Vegf Signalling

Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted signalling protein best known for its roles in vascular development and angiogenesis. Many non-endothelial roles for VEGF are now established, with the discovery that VEGF and its receptors VEGFR1 and VEGFR2 are expressed in many non-vascular cell-types, as well as various cancers. In addition to secreted VEGF binding to its receptors in the extracellular space at the cell membrane (i.e., in a paracrine or autocrine mode), intracellularly localised VEGF is emerging as an important signalling molecule regulating cell growth, survival, and metabolism. This intracellular mode of signalling has been termed “intracrine”, and refers to the direct action of a signalling molecule within the cell without being secreted. In this review, we describe examples of intracrine VEGF signalling in regulating cell growth, differentiation and survival, both in normal cell homeostasis and development, as well as in cancer. We further discuss emerging evidence for the molecular mechanisms underpinning VEGF intracrine function, as well as the implications this intracellular mode of VEGF signalling may have for use and design of anti-VEGF cancer therapeutics.

Sign in / Sign up

Export Citation Format

Share Document