scholarly journals Role of microRNAs in mammalian spermatogenesis and testicular germ cell tumors

Reproduction ◽  
2015 ◽  
Vol 149 (3) ◽  
pp. R127-R137 ◽  
Author(s):  
Li Wang ◽  
Chen Xu
Keyword(s):  
Germ Cell ◽  
Expression Profiles ◽  
Regulation Of Gene Expression ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Mirna Regulation ◽  
Testicular Germ Cell ◽  
Complex Process ◽  
Regulatory Functions

microRNAs (miRNAs) are a class of small endogenous RNAs, 19–25 nucleotides in size, which play a role in the regulation of gene expression at transcriptional and post-transcriptional levels. Spermatogenesis is a complex process through which spermatogonial stem cells (SSCs) proliferate and differentiate into mature spermatozoa. A large number of miRNAs are abundantly expressed in spermatogenic cells. Growing evidence supports the essential role of miRNA regulation in normal spermatogenesis and male fertility and cumulative research has shown that this form of regulation contributes to the etiology of testicular germ cell tumors (TGCTs). In this review, we addressed recent advancements of miRNA expression profiles in testis and focused on the regulatory functions of miRNA in the process of SSC renewal, spermatogonial mitosis, spermatocyte meiosis, spermiogenesis, and the occurrence of TGCTs.

scholarly journals The Role of the Mouse Y Chromosome on Susceptibility to Testicular Germ Cell Tumors

2009 ◽  
Vol 69 (8) ◽  
pp. 3614-3618 ◽  
Author(s):  
Philip D. Anderson ◽  
Man-Yee Lam ◽  
Christophe Poirier ◽  
Colin E. Bishop ◽  
Joseph H. Nadeau
Keyword(s):  
Germ Cell ◽  
Y Chromosome ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

The Role of Alkaline Phosphatase Isoenzymes as Tumor Markers for Testicular Germ Cell Tumors

1991 ◽  
Vol 146 (1) ◽  
pp. 57-60 ◽  
Author(s):  
K. Koshida ◽  
A. Nishino ◽  
H. Yamamoto ◽  
T. Uchibayashi ◽  
K. Naito ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Germ Cell ◽  
Tumor Markers ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Alkaline Phosphatase Isoenzymes

scholarly journals The role of microenvironment in testicular germ cell tumors

2010 ◽  
Vol 10 (6) ◽  
pp. 529-536 ◽  
Author(s):  
Alejandro Díez-Torre ◽  
Unai Silván ◽  
María Díaz-Núñez ◽  
Juan Arechaga
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

scholarly journals Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Stefania Staibano ◽  
Gennaro Ilardi ◽  
Vincenza Leone ◽  
Chiara Luise ◽  
Francesco Merolla ◽  
...  
Keyword(s):  
Germ Cell ◽  
Critical Role ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Neoplastic Growth

scholarly journals Expression Profiles of PIWIL2 Short Isoforms Differ in Testicular Germ Cell Tumors of Various Differentiation Subtypes

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112528 ◽  
Author(s):  
Ildar V. Gainetdinov ◽  
Yulia V. Skvortsova ◽  
Elena A. Stukacheva ◽  
Oksana S. Bychenko ◽  
Sofia A. Kondratieva ◽  
...  
Keyword(s):  
Germ Cell ◽  
Expression Profiles ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Short Isoforms

scholarly journals Testicular germ cell tumors: the changing role of the pathologist

2019 ◽  
Vol 7 (S6) ◽  
pp. S204-S204 ◽  
Author(s):  
Andrea Ronchi ◽  
Francesca Pagliuca ◽  
Renato Franco
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Changing Role

scholarly journals Integrated analysis of high-throughput sequencing data reveals the key role of LINC00467 in the invasion and metastasis of testicular germ cell tumors

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hao Bo ◽  
Fang Zhu ◽  
Zhizhong Liu ◽  
Qi Deng ◽  
Guangmin Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
High Throughput Sequencing ◽  
Expression Profiles ◽  
Germ Cell Tumors ◽  
Differentially Expressed ◽  
Migration And Invasion ◽  
Integrated Analysis ◽  
Sequencing Data ◽  
Testicular Germ Cell

AbstractLong noncoding RNAs (lncRNAs) are involved in various physiological and pathological processes. However, the role of lncRNAs in testicular germ cell tumor (TGCT) has been rarely reported. Our purpose is to comprehensively survey the expression and function of lncRNAs in TGCT. In this study, we used RNA sequencing to construct the lncRNA expression profiles of 13 TGCT tissues and 4 paraneoplastic tissues to explore the function of lncRNAs in TGCT. The bioinformatics analysis showed that many lncRNAs are differentially expressed in TGCT. GO and KEGG enrichment analyses revealed that the differentially expressed lncRNAs participated in various biological processes associated with tumorigenesis in cis and trans manners. Further, we found that the expression of LINC00467 was positively correlated with the poor prognosis and pathological grade of TGCT using WGCNA analysis and GEPIA database data mining. In vitro experiments revealed that LNC00467 could promote the migration and invasion of TGCT cells by regulating the expression of AKT3 and influencing total AKT phosphorylation. Further analysis of TCGA data revealed that the expression was negatively correlated with the infiltration of immune cells and the response to PD1 immunotherapy. In summary, this study is the first to construct the expression profile of lncRNAs in TGCT. It is also the first study to identify the metastasis-promoting role of LNC00467, which can be used as a potential predictor of TGCT prognosis and immunotherapeutic response to provide a clinical reference for the treatment and diagnosis of TGCT metastasis.

scholarly journals The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Mariëtte E. G. Kranendonk ◽  
Wenzel M. Hackeng ◽  
G. Johan A. Offerhaus ◽  
Folkert H. M. Morsink ◽  
Geertruida N. Jonges ◽  
...  
Keyword(s):  
Germ Cell ◽  
Molecular Pathology ◽  
Germ Cell Tumors ◽  
Decisive Role ◽  
Type Ii ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell
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