The Relationship between the Serum Aspartate Aminotransferase/Alanine Aminotransferase Ratio and Pulse Pressure in Korean Adults with Hypertension

Background: Liver plays a major role in detoxification and excretion of many endogenous and exogenous compounds. Any injury may lead to severe liver damage and impairment of liver function. Harbal plants such as Terminalia chebula (Haritaki) may have free radical scavenging activity thereby can be used for the prevention and treatment of liver damage.Objective: To observe the effect of Terminalia chebula on paracetamol induced changes of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in Wister albino rats.Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka from January to December 2013. Total 44 rats with age 90 to 120 days, weighing between 150 to 200 gm were selected. After acclimatization for 14 days, they were divided into base line control (BC, n=11), paracetamol treated control (PC, n=11),Terminalia chebula pretreated and paracetamol treated (TCP-PCT n=11) and paracetamol pretreated and Terminalia chebula treated group (PCP-TCT, n=11). All groups received basal diet for 21 consecutive days. In addition to basal diet, rats of BC received propylene glycol (2ml/kg body weight, orally) and PC received single dose of paracetamol suspension (750mg/kg body weight, orally) on 21st day. Rats of TCP-PCT received Terminalia chebula extract (200 mg/kg body weight, orally) for 21 consecutive days and paracetamol suspension (750mg/kg body weight, orally) on 21st day. Again, rats of PCP-TCT received paracetamol suspension (750mg/kg body weight, orally) on the 1st day and Terminalia chebula extract (200 mg/kg body weight orally) for 21 consecutive days. All rats were sacrificed on 22nd day and then blood samples were collected. For assessment of liver function serum AST and ALT levels were estimated by using standard laboratory kits. The statistical analysis was done by one way ANOVA and post hoc Bonferroni test as applicable.Results: The mean serum AST and ALT levels were significantly (p<0.001) higher in PC in comparison to those of BC. Serum AST and ALT levels of all experimental groups were significantly (P<0.001) lower than PC group. Conclusion: From the results of this study, it may be concluded that Terminalia chebula may have some hepatoprotective effects in paracetamol induced liver damage in rats.Bangladesh Soc Physiol. 2015, June; 10(1): 1-5

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Sex-speciﬁc in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

10.31083/jomh.2021.064 ◽

2021 ◽

Keyword(s):

Blood Pressure ◽

Uric Acid ◽

Confidence Interval ◽

National Health ◽

Pulse Pressure ◽

Nutrition Examination Survey ◽

Korean Adults ◽

Health And Nutrition ◽

The Relationship ◽

Significant Factors

Background and objective: The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults. Material and methods: Data from 5122 subjects (2251 men and 2871 women) in the seventh Korean National Health and Nutrition Examination Survey (KNHANES VII-2, 2017) were analyzed. Results: Systolic blood pressure (SBP) and PP were signiﬁcant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. In women, SBP, diastolic blood pressure (DBP), and PP were not signiﬁcant factors determining the OR for hyperuricemia. After adjusting for related variables, the OR of hyperuricemia was signiﬁcantly higher in the high PP group (PP >60.0 mmHg) for men (OR, 1.760; 95% conﬁdence interval [CI], 1.152--2.688) and the overall population (OR, 1.557; 95% CI, 1.132--2.140) compared with the normal PP group, but this trend was not seen in women (OR, 1.060; 95% CI, 0.646--1.740). Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women.

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Estimation of Serum Aspartate Aminotransferase and Alanine Aminotransferase

An Easy Guide for Practical Biochemistry ◽

10.5005/jp/books/14203_22 ◽

2018 ◽

pp. 182-182

Author(s):

Divya D’sa ◽

Sowbhagya Lakshmi

Keyword(s):

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Serum Aspartate Aminotransferase

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Gender difference in the relationship between lipid accumulation product index and pulse pressure in nondiabetic Korean adults: The Korean National Health and Nutrition Examination Survey 2013–2014

Clinical and Experimental Hypertension ◽

10.1080/10641963.2021.2007943 ◽

2021 ◽

pp. 1-8

Author(s):

Hyun Ho Sung ◽

Mi Young Gi ◽

Ju Ae Cha ◽

Hye Eun Cho ◽

Ae Eun Moon ◽

...

Keyword(s):

Gender Difference ◽

National Health ◽

Pulse Pressure ◽

Lipid Accumulation ◽

Nutrition Examination Survey ◽

Lipid Accumulation Product ◽

Korean Adults ◽

Health And Nutrition ◽

The Relationship ◽

Lipid Accumulation Product Index

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Influence of Gender on the Ratio of Serum Aspartate Aminotransferase (AST) to Alanine Aminotransferase (ALT) in Patients With and Without Hyperbilirubinemia

Digestive Diseases and Sciences ◽

10.1007/s10620-007-9924-z ◽

2007 ◽

Vol 53 (3) ◽

pp. 799-802 ◽

Cited By ~ 18

Author(s):

Jorge R. Mera ◽

Beverly Dickson ◽

Mark Feldman

Keyword(s):

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Serum Aspartate Aminotransferase

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Sources of Error in Spectrophotometric Measurement of Aspartate Aminotransferase and Alanine Aminotransferase Activities in Serum

Clinical Chemistry ◽

10.1093/clinchem/20.1.43 ◽

1974 ◽

Vol 20 (1) ◽

pp. 43-50 ◽

Cited By ~ 23

Author(s):

Denis O Rodgerson ◽

Iris M Osberg

Keyword(s):

Enzyme Activity ◽

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Short Interval ◽

Error Sources ◽

Double Beam ◽

Serum Aspartate Aminotransferase ◽

Endogenous Substrate ◽

Coupled Reactions ◽

Serum Glutamate

Abstract We examined the measurement of serum aspartate and alanine aminotransferase activities with a short-interval enzyme-activity analyzer. Double-beam spectrophotometry was used to elucidate the source of errors in such measurements. For both enzymes the principal error sources are: (a) the presence of endogenous substrate for lactate dehydrogenase, and (b) reaction of 2-oxoglutarate with serum glutamate dehydrogenase and ammonium ions added to the reaction mixture in admixture with the secondary enzymes of the coupled reactions. In the case of serum aspartate aminotransferase, a less important source of error is the reaction of serum alanine aminotransferase with endogenous substrate. Use of 2-oxoglutarate as a reaction initiator in conventional methods causes errors. Suitable blank reagent mixtures are described that permit accurate, rapid measurement of these activities by double-beam spectrophotometry in a short-interval enzyme-activity analyzer.

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