scholarly journals Effect of Catha edulis (khat) on pancreatic functions in streptozotocin-induced diabetes in male Sprague-Dawley rats

2018 ◽  
Vol 67 (4) ◽  
pp. 517-526 ◽  
Author(s):  
Abdulsamad Alsalahi ◽  
Mohammed A. Alshawsh ◽  
Zamri Chik ◽  
Zahurin Mohamed
Keyword(s):  
Sprague Dawley ◽  
Catha Edulis ◽  
Sprague Dawley Rats ◽  
Streptozotocin Induced Diabetes

scholarly journals Toxicological Features ofCatha edulis(Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Abdulsamad Alsalahi ◽  
Mahmood Ameen Abdulla ◽  
Mohammed Al-Mamary ◽  
Mohamed Ibrahim Noordin ◽  
Siddig Ibrahim Abdelwahab ◽  
...  
Keyword(s):  
Male Rats ◽  
High Dose ◽  
Sprague Dawley ◽  
Catha Edulis ◽  
Male And Female ◽  
Sd Rats ◽  
Sprague Dawley Rats ◽  
Serum Aspartate Aminotransferase ◽  
Liver And Kidney ◽  
Kg Medium

Hepato- and nephrotoxicity of Khat consumption (Catha edulisForskal) have been evoked. Therefore, this study was conducted to evaluate such possible hepatorenal toxicity in female and male Sprague-Dawley rats (SD rats) focusing primarily on liver and kidney. In addition, female and male rats were investigated separately. Accordingly, forty-eight SD-rats (100–120 g) were distributed randomly into four groups of males and female (n=12). Normal controls (NCs) received distilled water, whereas test groups received 500 mg/kg (low dose (LD)), 1000 mg/kg (medium dose (MD)), or 2000 mg/kg (high dose (HD)) of crude extract ofCatha edulisorally for 4 weeks. Then, physical, biochemical, hematological, and histological parameters were analyzed. Results in Khat-fed rats showed hepatic enlargement, abnormal findings in serum aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of male and female SD-rats and serum albumin (A) and serum creatinine (Cr) of female as compared to controls. In addition, histopathological abnormalities confirmed hepatic and renal toxicities of Khat that were related to heavy Khat consumption. In summary, Khat could be associated with hepatic hypertrophy and hepatotoxicity in male and female SD-rats and nephrotoxicity only in female SD-rats.

Effect of Streptozotocin-Induced Diabetes on Estradiol-Stimulated Changes in the Ultrastructure of the Rat Endometrium

1981 ◽  
Vol 39 ◽  
pp. 532-533
Author(s):  
G.T. Frederick ◽  
R.M. Gardner ◽  
J.M. Kirkland ◽  
G.M. Stancel
Keyword(s):  
Electron Microscopic Examination ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Thin Sections ◽  
Whole Cells ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sprague Dawley Rats ◽  
Uterine Growth ◽  
Streptozotocin Induced Diabetes

Estradiol (E2)-stimulated uterine growth has been well characterized both biochemically and morphologically. Recent studies have shown that insulin plays an important role in the regulation of cellular development. This study examines the effect of streptozotocin-induced diabetes on E2-stimulated changes in the ultrastructure of the endometrium of the rat uterus.Sprague-Dawley rats were ovariectomized at 21 days of age. Diabetes, defined as blood glucose levels greater than 300mg%, was induced in half of these animals by the injection of 85mg streptozotocin/kg body weight.The remaining animals were classified as normal. Animals from both groups were injected with either 0.9% saline or 4μg E2/100gm body weight. At 18, 24, 36 and 48 hours post-injection of E2, uterine segments were collected from 8-10 animals in each experimental group and processed for electron microscopic examination. Uterine segments from saline-injected animals served as controls. Data summarized describe observations made from thin-sections and have not been extrapolated for whole cells.

scholarly journals Streptozotocin-induced diabetes impairs Mg2+ homeostasis and uptake in rat liver cells

2004 ◽  
Vol 286 (2) ◽  
pp. E184-E193 ◽  
Author(s):  
Theresa E. Fagan ◽  
Christie Cefaratti ◽  
Andrea Romani
Keyword(s):  
Liver Cells ◽  
Atp Content ◽  
Sprague Dawley ◽  
Uptake Mechanism ◽  
Diabetes Onset ◽  
Kinase C ◽  
Sprague Dawley Rats ◽  
Rat Liver Cells ◽  
Streptozotocin Induced Diabetes ◽  
Stimulation Of

Male Sprague-Dawley rats rendered diabetic by streptozotocin injection presented 10 and 20% decreases in total hepatic Mg2+ content at 4 and 8 wk, respectively, following diabetes onset. This decrease was associated with a parallel decrease in K+ and ATP content and an increase in Na+ level. In diabetic liver cells, the Mg2+ extrusion elicited by α1-adrenoceptor stimulation was markedly reduced compared with nondiabetic livers, whereas that induced by β-adrenoceptor stimulation was unaffected. In addition, diabetic hepatocytes did not accumulate Mg2+ following stimulation of protein kinase C pathway by vasopressin, diacylglycerol analogs, or phorbol 12-myristate 13-acetate derivates despite the reduced basal content in cellular Mg2+. Experiments performed in purified plasma membrane from diabetic livers located the defect at the level of the bidirectional Na+/Mg2+ exchanger operating in the basolateral domain of the hepatocyte cell membrane, which could extrude but not accumulate Mg2+ in exchange for Na+. The impairment of Mg2+ uptake mechanism, in addition to the decrease in cellular ATP level, can contribute to explaining the decrease in liver Mg2+ content observed under diabetic conditions.

Cardio-protective effects of a dioxidovanadium(V) complex in male sprague–dawley rats with streptozotocin-induced diabetes

BioMetals ◽  
2020 ◽  
Author(s):  
Bonisiwe Mbatha ◽  
Andile Khathi ◽  
Ntethelelo Sibiya ◽  
Irvin Booysen ◽  
Patrick Mangundu ◽  
...  
Keyword(s):  
Protective Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Streptozotocin Induced Diabetes

Proconvulsant effect of khat (Catha edulis) in Sprague dawley rats

2009 ◽  
Vol 121 (3) ◽  
pp. 476-478 ◽  
Author(s):  
Eren Oyungu ◽  
Paul G. Kioy ◽  
Nilesh B. Patel
Keyword(s):  
Sprague Dawley ◽  
Catha Edulis ◽  
Sprague Dawley Rats

scholarly journals Bypassed and Preserved Stomach Resulted in Superior Glucose Control in Sprague-Dawley Rats with Streptozotocin-Induced Diabetes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jason Widjaja ◽  
Ponnie Robertlee Dolo ◽  
Qiang Zhang ◽  
Libin Yao ◽  
Chao Li ◽  
...  
Keyword(s):  
Glucose Control ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Streptozotocin Induced Diabetes

Influence of streptozotocin-induced diabetes and insulin on the functional capacity of rats

1981 ◽  
Vol 50 (3) ◽  
pp. 482-486 ◽  
Author(s):  
R. D. Murphy ◽  
A. C. Vailas ◽  
C. M. Tipton ◽  
R. D. Matthes ◽  
J. G. Edwards
Keyword(s):  
Functional Capacity ◽  
Time Course ◽  
Experimental Period ◽  
Maximum Oxygen Consumption ◽  
Sprague Dawley ◽  
Heart Rates ◽  
Sprague Dawley Rats ◽  
Streptozotocin Induced Diabetes ◽  
Lower Maximum ◽  
And Control

Male Sprague-Dawley rats were assigned to three groups designated as diabetic, diabetic-plus-insulin, and control and tested for maximum oxygen consumption (VO2max) and maximum heart rate on three different occasions during the 6- to 8-wk experimental period. Compared with the prediabetic values and the means of the other two groups, diabetic animals had significantly higher submaximum and lower maximum VO2 values. These relationships prevailed when the groups were evaluated in terms of ml.kg-1.min-1 or ml.(kg0.79-1).min-1. In addition, the diabetic animals had significantly lower submaximum and maximum heart rates and shorter run times. Daily injections of insulin (2 U.day-1.rat-1) restored VO2max to within the limits of the control animals but did not normalize heart rates or run-time values. The linear relationship between heart rates and VO2 was repeatedly demonstrated with normal animals. However, this relationship progressively declined with the time course of diabetes. These results indicate that, in untreated diabetes, functional capacity is markedly reduced with the progression of the disease and suggest that alterations in the autonomic nervous system, tissue metabolic capacity, and decreases in lean body mass are responsible for the changes noted.

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