scholarly journals Rate-Correction Technique for QT Interval in Long-Term Telemetry ECG Recording in Beagle Dogs.

2002 ◽  
Vol 51 (5) ◽  
pp. 465-475 ◽  
Author(s):  
Hiroyasu MIYAZAKI ◽  
Masahiro TAGAWA
Keyword(s):  
Qt Interval ◽  
Beagle Dogs ◽  
Correction Technique ◽  
Telemetry Ecg

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

scholarly journals No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1799
Author(s):  
Jujhar Atwal ◽  
Jonathan Stockman ◽  
Matthew Gilham ◽  
David Allaway ◽  
Helen Renfrew ◽  
...  
Keyword(s):  
Filtration Rate ◽  
Fold Increase ◽  
Diet Group ◽  
Test Diet ◽  
Beagle Dogs ◽  
Adverse Health Effects ◽  
Mineral Balance ◽  
High Calcium ◽  
High Calcium Diet

The implications of long-term high calcium (Ca) intake are well documented in growing dogs and in adult dogs of large breed size, however, the consequences on other breeds and breed sizes are yet to be determined. Eighteen neutered adult beagles, nine males and nine females aged 1.4–4.4 years, were randomized to control or test diets providing in g∙4184 kJ−1 (1000 kcal−1): 1.44 and 7.19 total Ca balanced with 1.05 and 4.25 total phosphorus, respectively, for 40 weeks. Health parameters, ultrasound scans, radiographs, glomerular filtration rate, and mineral balance were measured at eight-week intervals. All dogs remained healthy with no measured evidence of orthopedic, urinary, or renal disease. The test diet resulted in a 5.2 fold increase in fecal Ca excretion. Apparent Ca digestibility (%) and Ca balance (g/d) did not significantly (p > 0.05) change from baseline in the test diet group, although dogs displayed a positive Ca balance (maximum at week 8, 1.11 g/d with 95% CI (0.41, 1.80)) before a neutral Ca balance was restored at week 32. Despite an initial positive Ca balance, we can conclude that no measurable adverse health effects were observed as a result of the test diet fed in this study in beagles over a period of 40 weeks.

scholarly journals Transitional Cell Carcinomas of the Urinary Tract in a Colony of Beagle Dogs

1989 ◽  
Vol 26 (6) ◽  
pp. 455-461 ◽  
Author(s):  
K. J. Nikula ◽  
S. A. Benjamin ◽  
G. M. Angleton ◽  
A. C. Lee
Keyword(s):  
Urinary Tract ◽  
Transitional Cell ◽  
Clinical Signs ◽  
Conclusive Evidence ◽  
Whole Body ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Significant Difference ◽  
Microscopic Features

Gross and light microscopic features of transitional cell carcinomas (TCC) of the urinary tract were examined in Beagle dogs used for the study of the long-term effects of low-dose, whole-body, 60Co gamma radiation. Thirty-eight cases of TCC occurred among 990 dogs that were from 0 to 14 years of age. There was no conclusive evidence of a radiation effect. The 38 TCC were equally divided between male and female dogs, but there was a significant difference in the sex distribution of urethra-origin TCC. Eleven males had a primary urethral TCC compared to only two females. There was no significant difference between the urethra-origin and bladder-origin TCCs in the number of tumors that caused clinical signs, metastasized, or that contributed to the death of the dog. All cases of urethral TCC in male dogs occurred in the prostatic urethra. The majority of these cases were not recognized to be neoplasms at gross necropsy, but microscopic examination revealed the TCC. Our findings differ from previous reports stating that TCC occurs more frequently in female than male dogs, and they especially differ from reports claiming that urethra-origin TCC is predominately a disease of female dogs.

Effects of body temperature on QT interval in beagle dogs

2009 ◽  
Vol 60 (2) ◽  
pp. 237-238 ◽  
Author(s):  
Laurie J. Shellhammer ◽  
Maxim Soloviev ◽  
Kenneth Kearney ◽  
Philip Atterson
Keyword(s):  
Body Temperature ◽  
Qt Interval ◽  
Beagle Dogs

Proliferation capacity of T-lymphocytes is affected transiently after a long-term weight gain in Beagle dogs

2013 ◽  
Vol 152 (3-4) ◽  
pp. 237-244 ◽  
Author(s):  
H. Van de Velde ◽  
G.P.J. Janssens ◽  
K. Rochus ◽  
L. Duchateau ◽  
L. Scharek-Tedin ◽  
...  
Keyword(s):  
Weight Gain ◽  
T Lymphocytes ◽  
Beagle Dogs ◽  
Proliferation Capacity

External monitoring of 203Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

Parasitology ◽  
1986 ◽  
Vol 92 (2) ◽  
pp. 463-469 ◽  
Author(s):  
F. W. Lengemann ◽  
R. B. Grieve ◽  
M. Chmielewicz ◽  
F. A. Kallfelz ◽  
J. R. Georgi
Keyword(s):  
Dirofilaria Immitis ◽  
Half Time ◽  
Beagle Dogs ◽  
External Monitoring

SUMMARYMicrofilariae of Dirofliaria immitis were labelled with 203Hg 2+in vitro and injected into irradiated mice and Beagle dogs. With irradiated mice it was possible to demonstrate microfilariae present in the blood and to detect 203Hg by external counting as long as 28 days after dosing. The 203Hg 2+ label had a half-time of 4–5 days; the amount of stable mercury in the labelling medium strongly influenced the survival of microfilariae in vivo. In dogs, external counting showed the lungs to be a major location of the microfilariae soon after reinjection into the host. Evidence was obtained that labelled microfilariae can circulate; however, the detection of dispersed microfilariae is difficult because of the relative insensitivity of the detecting system. For radiomercury the accumulation of the inorganic form in the liver and kidneys limits the long-term usefulness of 203Hg 2+ as a label if the organism being studied also accumulates in these organs.

scholarly journals Preliminary study: voluntary food intake in dogs during tryptophan supplementation

2011 ◽  
Vol 106 (S1) ◽  
pp. S162-S165 ◽  
Author(s):  
Víctor Fragua ◽  
Gemma González-Ortiz ◽  
Cecilia Villaverde ◽  
Marta Hervera ◽  
Valentina Maria Mariotti ◽  
...  
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Essential Amino Acid ◽  
Beagle Dogs ◽  
Supplementation Period ◽  
Preliminary Study ◽  
Serum Ghrelin ◽  
Voluntary Food Intake

Tryptophan, a precursor of important molecules such as serotonin, melatonin and niacin, is an essential amino acid for dogs. In pigs, tryptophan supplementation has been shown to induce a significant increase in food intake. The aim of the present study was to assess whether long-term tryptophan supplementation increases voluntary food intake in dogs and to observe whether this was accompanied by a change in serum ghrelin. In the present study, sixteen adult Beagle dogs were used, with four male and four female dogs fed diets supplemented with tryptophan (1 g/dog per d) during 81 d (Trp) and four male and four female dogs that were not supplemented (control). A voluntary food intake test was performed during 5 d following the supplementation period. The Trp group tended to show a higher food intake during the voluntary food intake test (58·0 (se 5·37) v. 77·5 (se 3·65) g/kg metabolic weight per d; P = 0·074). No significant differences were found for serum ghrelin concentrations.

scholarly journals Microdistribution and Long-term Retention of 239Pu (NO3)4 in the Respiratory Tracts of an Acutely Exposed Plutonium Worker and Experimental Beagle Dogs

2012 ◽  
Vol 72 (21) ◽  
pp. 5529-5536 ◽  
Author(s):  
Christopher E. Nielsen ◽  
Dulaney A. Wilson ◽  
Antone L. Brooks ◽  
Stacey L. McCord ◽  
Gerald E. Dagle ◽  
...  
Keyword(s):  
Beagle Dogs ◽  
Term Retention ◽  
Long Term Retention
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