scholarly journals Molecular Analyses of MHC Genes and T Cell Receptor V.BETA. Gene Usage in the NOD Mouse and Its Nondiabetic Sister Strains.

1991 ◽  
Vol 7 ◽  
pp. 24-32
Author(s):  
Yukio KOIDE ◽  
Takato O. YOSHIDA
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Nod Mouse ◽  
Molecular Analyses ◽  
Mhc Genes ◽  
Gene Usage

scholarly journals Peripheral CD25 positive T lymphocytes with biased T cell receptor V  gene usage in autoimmune endogenous posterior uveitis

1995 ◽  
Vol 48 (1) ◽  
pp. M46-M50 ◽  
Author(s):  
P J Tighe ◽  
J V Forrester ◽  
J Liversidge ◽  
H F Sewell
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Posterior Uveitis ◽  
Gene Usage ◽  
V Gene

T-cell receptor gene usage and expression in renal allograft-derived T-cell lines

1990 ◽  
Vol 28 (2) ◽  
pp. 82-95 ◽  
Author(s):  
Susan L. Hand ◽  
Bruce Lee Hall ◽  
Olivera J. Finn
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Lines ◽  
Renal Allograft ◽  
Receptor Gene ◽  
Cell Receptor ◽  
Gene Usage ◽  
T Cell Receptor Gene ◽  
T Cell Lines ◽  
Cell Receptor Gene

scholarly journals T Cell Receptor β Chain Gene Usage in Endemic Pemphigus Foliaceus (Fogo Selvagem)

2002 ◽  
Vol 119 (2) ◽  
pp. 377-383 ◽  
Author(s):  
Achim K. Moesta ◽  
Animesh A. Sinha ◽  
Mong-Shang Lin ◽  
Luis A. Diaz
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Pemphigus Foliaceus ◽  
Gene Usage ◽  
Endemic Pemphigus Foliaceus ◽  
Β Chain

Detection of skewed T-cell receptor V-β gene usage in the peripheral blood of patients with multiple sclerosis

1998 ◽  
Vol 85 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Bruno Gran ◽  
Donella Gestri ◽  
Alessandra Sottini ◽  
Eugenia Quiròs Roldàn ◽  
Alessandra Bettinardi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Receptor ◽  
Peripheral Blood ◽  
Cell Receptor ◽  
Gene Usage

scholarly journals Gamma/delta lineage relationship within a consecutive series of human precursor T-cell neoplasms

Blood ◽  
1989 ◽  
Vol 74 (7) ◽  
pp. 2508-2518 ◽  
Author(s):  
JP de Villartay ◽  
AB Pullman ◽  
R Andrade ◽  
E Tschachler ◽  
O Colamenici ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Consecutive Series ◽  
Gene Rearrangements ◽  
Gamma Delta ◽  
Delta Gene ◽  
Gene Usage ◽  
Rearrangement Process ◽  
Gamma Delta T Cell

Abstract We analyzed the gene rearrangements associated with the newly described delta T-cell receptor (TCR) gene from a series of 19 consecutive precursor T-cell (lymphoblastic) neoplasms that represent discrete stages surrounding the TCR gene rearrangement process. Significantly, the delta TCR gene showed rearrangement in most (13 of 19) of these T cells, and in addition it was rearranged in two cells displaying no rearrangement for any other TCR gene. Our survey showed three types of delta gene rearrangements associated with cell-surface TCR expression that presumably represent usage of three V delta genes. This analysis demonstrates (1) a major subclass of human precursor T-cell neoplasms belonging to the gamma/delta T-cell receptor-rearranging subtype; (2) a narrow repertoire of human V delta gene usage; and (3) the utility of delta gene rearrangements as a diagnostic clonal marker in precursor T lymphoblastic neoplasms.

Analysis of T cell receptor Vβ gene usage during the course of disease in patients with chronic hepatitis B

1998 ◽  
Vol 5 (6) ◽  
pp. 428-434
Author(s):  
Horng-yunn Dou ◽  
Jaw-Ching Wu ◽  
Wei-li Peng ◽  
Chungming Chang ◽  
Wei-Kuang Chi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Course Of Disease ◽  
Gene Usage ◽  
T Cell Receptor Vβ

scholarly journals An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 ◽  
Vol 180 (3) ◽  
pp. 1171-1176 ◽  
Author(s):  
P Dellabona ◽  
E Padovan ◽  
G Casorati ◽  
M Brockhaus ◽  
A Lanzavecchia
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Clone ◽  
Cell Subset ◽  
Cell Receptor ◽  
T Cell Subsets ◽  
T Cell Clone ◽  
Gene Usage ◽  
Beta Gene

The T cell receptor (TCR)-alpha/beta CD4-8- (double negative, DN) T cell subset is characterized by an oligoclonal repertoire and a restricted V gene usage. By immunizing mice with a DN T cell clone we generated two monoclonal antibodies (mAbs) against V alpha 24 and V beta 11, which have been reported to be preferentially expressed in DN T cells. Using these antibodies, we could investigate the expression and pairing of these V alpha and V beta gene products among different T cell subsets. V alpha 24 is rarely expressed among CD4+ and especially CD8+ T cells. In these cases it is rearranged to different J alpha segments, carries N nucleotides, and pairs with different V beta. Remarkably, V alpha 24 is frequently expressed among DN T cells and is always present as an invariant rearrangement with J alpha Q, without N region diversity. This invariant V alpha 24 chain is always paired to V beta 11. This unique V alpha 24-J alpha Q/V beta 11 TCR was found in expanded DN clones from all the individuals tested. These findings suggest that the frequent occurrence of cells carrying this invariant TCR is due to peripheral expansion of rare clones after recognition of a nonpolymorphic ligand.

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