scholarly journals Implementation of postgenomic technologies for cancer research. Institutional experience

2010 ◽  
Vol 17 (3-4) ◽  
pp. 100-105
Author(s):  
Martina RUDGALVYTĖ ◽  
Diana STANČIŪTĖ ◽  
Kristina BIELSKIENĖ ◽  
Violeta JONUŠIENĖ ◽  
Vida KIRVELIENĖ ◽  
...  
Keyword(s):  
Cancer Research ◽  
Molecular Biology ◽  
Biomedical Research ◽  
New Technologies ◽  
Rapid Development ◽  
Financial Resources ◽  
The Past ◽  
Genomic Technologies ◽  
Institutional Experience

Advance in molecular biology and the new technologies for biomedical research are being rapidly introduced into the research of complex pathologies worldwide. Implementation of these technologies, however, needs substantial financial resources for the equipment and for training the specialists. The rapid development of biomedical research over the past decade increases the risk of moral ageing of the implemented technologies and raises doubts as to whether countries with limited financial resources could afford them. In this article, we share our institutional experience in the implementation of post-genomic technologies in cancer research in Lithuania and stress the need of modern infrastructure in biomedical research, despite the needed efforts and associated risks. Keywords: postgenomic technologies, cancer research

scholarly journals Smarter–lighter–greener: research innovations for the automotive sector

2015 ◽  
Vol 471 (2179) ◽  
pp. 20140938 ◽  
Author(s):  
S. K. Bhattacharyya
Keyword(s):  
Smart Materials ◽  
New Technologies ◽  
Rapid Development ◽  
Transport Infrastructure ◽  
Past Century ◽  
Automotive Sector ◽  
Propulsion Systems ◽  
The Past ◽  
Light Weighting ◽  
Human Desire

This paper reviews the changing nature of research underpinning the revolution in the automotive sector. Legislation controlling vehicle emissions has brought urgency to research, so we are now noticing a more rapid development of new technologies than at any time in the past century. The light-weighting of structures, the refinement of advanced propulsion systems, the advent of new smart materials, and greater in-vehicle intelligence and connectivity with transport infrastructure all require a fundamental rethink of established technologies used for many decades—defining a range of new multi-disciplinary research challenges. While meeting escalating emission penalties, cars must also fulfil the human desire for speed, reliability, beauty, refinement and elegance, qualities that mark out the truly great automobile.

Crochet microentrepreneurs and technology: A collective case study

2021 ◽  
Vol 12 (2) ◽  
pp. 275-293 ◽  
Author(s):  
Marie Segares
Keyword(s):  
Technology Adoption ◽  
New Technologies ◽  
Local Area ◽  
Financial Resources ◽  
Collective Case Study ◽  
Developed Economies ◽  
Supportive Environment ◽  
The Past ◽  
Income Sources

Artisan entrepreneurship has been increasing in developed economies in the past decade. In order for artisan enterprises to thrive, these businesses would benefit from using technology to access global marketplaces, add value to their consumers and market beyond their local area. Unless operating as a collective, most artisan entrepreneurs manage microbusinesses with ten or fewer employees. Microbusiness owners face challenges to adopting technology including limited financial resources, lack of technological expertise and owner’s attitudes about technology. Extant research has not examined why and how artisan entrepreneurs introduce technology into their businesses. Crochet is an artisanal craft that can only be produced by hand without requiring any contemporary technological solutions. This collective case study explored how five women crochet artisan microentrepreneurs navigated the process of introducing new technologies into their businesses. Findings indicate that crochet artisan microentrepreneurs have diverse income sources, which are enabled by technology adoption. The communitarian nature of the artisan entrepreneur ‘ecosystem’ provides a supportive environment that facilitates the process of identifying, selecting and learning new technologies. Cost and perceived lack of self-efficacy are significant obstacles to technology adoption for crochet artisan microentrepreneurs. This study adds to the existing research on artisan entrepreneurship by exploring technology adoption in this context and sharing the perceived benefits and challenges experienced with other artisan microentrepreneurs.

Ultrastructure and analytical microprobe analysis of simian lung mite pigments

1986 ◽  
Vol 44 ◽  
pp. 324-325
Author(s):  
R. W. Cole ◽  
J. C. Kim
Keyword(s):  
Biomedical Research ◽  
Tissue Damage ◽  
Microprobe Analysis ◽  
Old World Monkeys ◽  
Old World ◽  
Experimental Animals ◽  
The Past ◽  
Lung Mite ◽  
Mite Infestations ◽  
Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

Impact of microRNAs on molecular epidemiology

2011 ◽  
Vol 152 (16) ◽  
pp. 633-641 ◽  
Author(s):  
Katalin Gőcze ◽  
Katalin Gombos ◽  
Gábor Pajkos ◽  
Ingrid Magda ◽  
Ágoston Ember ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Cancer Research ◽  
Molecular Epidemiology ◽  
Wide Spectrum ◽  
Translation Regulation ◽  
Rna Sequences ◽  
Serum Mirna ◽  
The Past ◽  
Non Coding Rna ◽  
Free Serum

Cancer research concerning short non-coding RNA sequences and functionally linked to RNA interference (RNAi) have reached explosive breakthrough in the past decade. Molecular technology applies microRNA in extremely wide spectrum from molecular tumor prediction, diagnostics, progression monitoring and prevention. Functional analysis of tissue miRNA and cell-free serum miRNA in posttranscription and translation regulation innovated and restructured the knowledge on the field. This review focuses on molecular epidemiology and primary prevention aspects of the small non-coding RNA sequences. Orv. Hetil., 2011, 152, 633–641.

Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Gene Expression ◽  
Cancer Research ◽  
Molecular Epidemiology ◽  
Exposure Assessment ◽  
Large Scale ◽  
First Generation ◽  
Cancer Epidemiology ◽  
Policy Changes ◽  
The Past ◽  
New Generation

The purpose of this review is to evaluate progress inmolecular epidemiology over the past 24 years in canceretiology and prevention to draw lessons for futureresearch incorporating the new generation of biomarkers.Molecular epidemiology was introduced inthe study of cancer in the early 1980s, with theexpectation that it would help overcome some majorlimitations of epidemiology and facilitate cancerprevention. The expectation was that biomarkerswould improve exposure assessment, document earlychanges preceding disease, and identify subgroupsin the population with greater susceptibility to cancer,thereby increasing the ability of epidemiologic studiesto identify causes and elucidate mechanisms incarcinogenesis. The first generation of biomarkers hasindeed contributed to our understanding of riskandsusceptibility related largely to genotoxic carcinogens.Consequently, interventions and policy changes havebeen mounted to reduce riskfrom several importantenvironmental carcinogens. Several new and promisingbiomarkers are now becoming available for epidemiologicstudies, thanks to the development of highthroughputtechnologies and theoretical advances inbiology. These include toxicogenomics, alterations ingene methylation and gene expression, proteomics, andmetabonomics, which allow large-scale studies, includingdiscovery-oriented as well as hypothesis-testinginvestigations. However, most of these newer biomarkershave not been adequately validated, and theirrole in the causal paradigm is not clear. There is a needfor their systematic validation using principles andcriteria established over the past several decades inmolecular cancer epidemiology.

The Synergy between CRISPR and Chemical Engineering

2019 ◽  
Vol 19 (3) ◽  
pp. 147-171
Author(s):  
Cia-Hin Lau ◽  
Chung Tin
Keyword(s):  
Viral Vectors ◽  
Chemical Engineering ◽  
Target Genes ◽  
New Technologies ◽  
Rapid Development ◽  
Genetic Circuits ◽  
Viral Packaging ◽  
Conditional Control ◽  
Logic Operations

Gene therapy and transgenic research have advanced quickly in recent years due to the development of CRISPR technology. The rapid development of CRISPR technology has been largely benefited by chemical engineering. Firstly, chemical or synthetic substance enables spatiotemporal and conditional control of Cas9 or dCas9 activities. It prevents the leaky expression of CRISPR components, as well as minimizes toxicity and off-target effects. Multi-input logic operations and complex genetic circuits can also be implemented via multiplexed and orthogonal regulation of target genes. Secondly, rational chemical modifications to the sgRNA enhance gene editing efficiency and specificity by improving sgRNA stability and binding affinity to on-target genomic loci, and hence reducing off-target mismatches and systemic immunogenicity. Chemically-modified Cas9 mRNA is also more active and less immunogenic than the native mRNA. Thirdly, nonviral vehicles can circumvent the challenges associated with viral packaging and production through the delivery of Cas9-sgRNA ribonucleoprotein complex or large Cas9 expression plasmids. Multi-functional nanovectors enhance genome editing in vivo by overcoming multiple physiological barriers, enabling ligand-targeted cellular uptake, and blood-brain barrier crossing. Chemical engineering can also facilitate viral-based delivery by improving vector internalization, allowing tissue-specific transgene expression, and preventing inactivation of the viral vectors in vivo. This review aims to discuss how chemical engineering has helped improve existing CRISPR applications and enable new technologies for biomedical research. The usefulness, advantages, and molecular action for each chemical engineering approach are also highlighted.

History—an overview

2018 ◽  
Author(s):  
Oriol Bohigas ◽  
Hans A. Weidenmüller
Keyword(s):  
Random Matrix Theory ◽  
Random Matrix ◽  
Matrix Theory ◽  
Rapid Development ◽  
The Past ◽  
History Of ◽  
And Mathematics

An overview of the history of random matrix theory (RMT) is provided in this chapter. Starting from its inception, the authors sketch the history of RMT until about 1990, focusing their attention on the first four decades of RMT. Later developments are partially covered. In the past 20 years RMT has experienced rapid development and has expanded into a number of areas of physics and mathematics.

scholarly journals Therapeutic Advances in Oncology

2021 ◽  
Vol 22 (4) ◽  
pp. 2008
Author(s):  
Jinsha Liu ◽  
Priyanka Pandya ◽  
Sepideh Afshar
Keyword(s):  
Small Molecules ◽  
New Technologies ◽  
Treatment Options ◽  
Current Treatment ◽  
Bispecific Antibodies ◽  
Gene Therapies ◽  
Therapeutic Modalities ◽  
The Past ◽  
Drug Conjugates ◽  
Novel Targets

Around 77 new oncology drugs were approved by the FDA in the past five years; however, most cancers remain untreated. Small molecules and antibodies are dominant therapeutic modalities in oncology. Antibody-drug conjugates, bispecific antibodies, peptides, cell, and gene-therapies are emerging to address the unmet patient need. Advancement in the discovery and development platforms, identification of novel targets, and emergence of new technologies have greatly expanded the treatment options for patients. Here, we provide an overview of various therapeutic modalities and the current treatment options in oncology, and an in-depth discussion of the therapeutics in the preclinical stage for the treatment of breast cancer, lung cancer, and multiple myeloma.

The Future of the Planetary Trust in a Kaleidoscopic World

2021 ◽  
pp. 1-8
Author(s):  
Edith Brown Weiss
Keyword(s):  
Artificial Intelligence ◽  
Natural Resource ◽  
Human Activities ◽  
New Technologies ◽  
Future Generations ◽  
Nuclear War ◽  
Human Environment ◽  
The Past ◽  
Resource Degradation ◽  
Shared Goal

Today, it is evident that we are part of a planetary trust. Conserving our planet represents a public good, global as well as local. The threats to future generations resulting from human activities make applying the normative framework of a planetary trust even more urgent than in the past decades. Initially, the planetary trust focused primarily on threats to the natural system of our human environment such as pollution and natural resource degradation, and on threats to cultural heritage. Now, we face a higher threat of nuclear war, cyber wars, and threats from gene drivers that can cause inheritable changes to genes, potential threats from other new technologies such as artificial intelligence, and possible pandemics. In this context, it is proposed that in the kaleidoscopic world, we must engage all the actors to cooperate with the shared goal of caring for and maintaining planet Earth in trust for present and future generations.

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