scholarly journals Role of Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet Large Cell Ratio (P-LCR) Value in the Diagnosis of Immune Thrombocytopenic Purpura

2016 ◽  
Vol 2 (2) ◽  
Author(s):  
Mesbah Uddin Ahmed
Keyword(s):  
Immune Thrombocytopenic Purpura ◽  
Mean Platelet Volume ◽  
Large Cell ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Thrombocytopenic Purpura ◽  
Distribution Width ◽  
Cell Ratio

scholarly journals RELATIONSHIP BETWEEN RED BLOOD CELL AND PLATELET INDICES IN IRON DEFICIENCY ANEMIA

2021 ◽  
Vol 71 (2) ◽  
pp. 575-78
Author(s):  
Sahar Rabbani ◽  
Muhammad Farooq ◽  
Samina Naeem ◽  
, Muhammad Abdul Naeem ◽  
Nasir Uddin ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Red Blood Cell ◽  
Mean Platelet Volume ◽  
Large Cell ◽  
Deficiency Anemia ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Cell Ratio

Objective: To find out the correlation between the red blood cell and platelet indices in patients presenting with iron deficiency anemia at a tertiary care hospital of Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Department of Hematology, Combined Military Hospital Lahore, from Sep 2018 to Mar 2019. Methodology: The patients of age 1-70 years of either gender presenting with IDA were included in the study. The blood sample of patients were sent to laboratory to assess the red blood cell and platelet indices. SPSS-23 was used to analyze data. Results: Two hundred and seven patients fulfilling the inclusion criteria were included in this study. The mean age was 25.6 ±17.8years. Correlation was weak and insignificant between haemoglobin and packed cell volume (r=-0.385**, p<0.01), haemoglobin and mean cell volume (r=-0.225**, p<0.01), packed cell volume and mean cell haemoglobin (r =0.263**, p<0.01), & mean cell haemoglobin and mean platelet volume (r=0.143*, p<0.05). Correlation was moderate and significant between platelet distribution width and mean platelet volume (r=0.511**) & platelet distribution width and platelet large cell ratio (0.502**, p<0.01). Correlation was strong between mean platelet volume and platelet large cell ratio (r=0.759**, p<0.01). Conclusion: In conclusion, there was significant relation between red blood cell and platelets indices in iron deficiency anemia. Furthermore, haemoglobin and packed cell volume are weekly correlated, platelet distribution width and mean platelet volume are moderately correlated and mean platelet volume and platelet large cell ratio are strongly correlated.

scholarly journals Study of Platelet Indices and Their Interpretation in Thrombocytopenia in a Tertiary Care Hospital

2021 ◽  
Vol 10 (7) ◽  
pp. 435-439
Author(s):  
Vani Mittal ◽  
Munesh Munesh ◽  
Irbinder Kour Bali ◽  
Sunil Arora ◽  
Jyoti Singh ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Large Cell ◽  
Care Hospital ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Cell Ratio ◽  
Platelet Indices ◽  
Significant Difference

BACKGROUND Thrombocytopenia may either be due to increased destruction or impaired production of platelets. Platelet count alone is not enough to determine the mechanism of low platelets. Platelet indices like mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR) and platelet crit (PCT) can help determine the cause and we aimed at finding their role and function in cases of thrombocytopenia. METHODS An observational cross-sectional study of 155 patients with thrombocytopenia and 71 controls was done for a period of six months in SGT Hospital, Gurugram, to determine the mechanism behind the low platelet count with the help of these indices. RESULTS The mean values of the platelet indices (PDW, P-LCR and PCT) were found to be higher in accelerated destruction group (P < 0.05) in comparison to hypoproductive group, whereas, mean MPV values were higher in the former, but was not statistically significant. On comparison with the controls, both the groups of thrombocytopenia showed a statistically significant difference with P < 0.005 in all the four indices. Mean PCT values showed a highly significant difference between the two groups as well as with controls (P < 0.001) and also the relationship of PCT with severity of thrombocytopenia showed a direct relationship which was also significant (P < 0.001). CONCLUSIONS In distinguishing between the cause of thrombocytopenia i.e., hypoproductive or hyper destruction, platelet parameters play an important role. These platelet indices are easily available with the help of automated haematology analysers and can reduce the need for costly and invasive tests for evaluation of thrombocytopenia. KEY WORDS Mean Platelet Volume, Platelet crit, Platelet Distribution Width, Platelet Large Cell Ratio, Thrombocytopenia

Mean Platelet Volume, Platelet Distribution Width, and Platelet Count, in Connection with Immune Thrombocytopenic Purpura and Essential Thrombocytopenia

2019 ◽  
Vol 50 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Eunyup Lee ◽  
Miyoung Kim ◽  
Kibum Jeon ◽  
Jiwon Lee ◽  
Jee-Soo Lee ◽  
...  
Keyword(s):  
Platelet Count ◽  
Immune Thrombocytopenic Purpura ◽  
Mean Platelet Volume ◽  
Platelet Distribution Width ◽  
Kinetic Characteristics ◽  
Healthy Individuals ◽  
Platelet Volume ◽  
Thrombocytopenic Purpura ◽  
Distribution Width

AbstractObjectiveTo examine the kinetic characteristics of platelet (PLT) destruction and thrombopoiesis by using mean platelet volume (MPV) and platelet distribution width (PDW).MethodsUsing the ADVIA2120i instrument, we measured PLT counts, MPV, and PDW in 153 healthy individuals, 35 patients with immune thrombocytopenic purpura (ITP), and 48 patients with essential thrombocytopenia (ET).ResultsIn the ITP group, the MPV and PDW were higher than those values in healthy individuals. In the ET group, the MPV was lower than in the ITP group and in healthy individuals, and the PDW was lower than in the ITP group. When the ITP group was subdivided (PLT counts <45 × 103/µL vs ≥ 45 × 103/µL), the MPV and PDW tended to be higher in patients with PLT counts less than 45 × 103 per µL. When patients with ET were subdivided (PLT counts <770 × 103/µL vs ≥770 × 103/µL), the MPV and PDW were lower in patients with PLT count of 770 or greater × 103 per µL.ConclusionsIn ITP, the overall PLT composition varies, and PLT sequestration is nondiscriminatory. In ET, PLTs quickly shrink and remain small, resulting in a high proportion of small-sized PLTs.

Flow Cytometry With Inflorescence-An Accessible Method in the Study of Qualitative and Quantitative Modifications of Blood Platelets in Immune Thrombocytopenic Purpura

2018 ◽  
Vol 69 (9) ◽  
pp. 2476-2478
Author(s):  
Oana Viola Badulescu ◽  
Magda Badescu ◽  
Manuela Ciocoiu ◽  
Madalina Mocanu
Keyword(s):  
Flow Cytometry ◽  
Immune Thrombocytopenic Purpura ◽  
Mean Platelet Volume ◽  
Blood Platelets ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Thrombocytopenic Purpura ◽  
Distribution Width ◽  
Accessible Method ◽  
The Mean

The immune thrombocytopenic purpura (ITP) is a polymorphic and hematologic pathology, in terms of both clinical manifestations and etiopathogenic mechanisms, which bring on this disease. Establishing the type of thrombocytopenia, which can either be primary or secondary, peripheral or central, is essential for a further proper therapeutic conduct. The current means of diagnosis include a large variety of hematologic, immunologic and biochemical explorations, from the traditional ones to the latest methods, either genetical or molecular. The purpose of this paper is to emphasize the importance of a classical method of diagnosis, used in the primary triage of patients suffering from thrombocytopenia, highly valuable in the diagnosis process: the analysis of the mean platelet volume (MPV) and of the platelet distribution width (PDW), parameters revealed by the CBC (complete blood count). Evaluating the size of the platelets is a useful tool in the differential diagnosis between immune thrombocytopenic purpura and hereditary macrothrombocytopenia. The platelet distribution width and the mean platelet volume are read simultaneously, in order to differentiate the immune peripheral thrombocytopenia from the central one. The classical, viable and accessible method facilitates the measurement of MPV and PDW with the automatic analyzer, which functions according to the principle of flow cytometry with inflorescence, by using a LASER semiconductor and hydrodynamic focusing.

scholarly journals Platelets volume indexes and cardiovascular risk factors

2018 ◽  
Vol 64 (6) ◽  
pp. 554-559 ◽  
Author(s):  
Thaís Resende Batista ◽  
Roberta Carvalho de Figueiredo ◽  
Danyelle Romana Alves Rios
Keyword(s):  
Risk Factors ◽  
Large Cell ◽  
Review Literature ◽  
Preventive Strategies ◽  
Platelet Distribution Width ◽  
Epidemiological Evidence ◽  
Platelet Volume ◽  
Distribution Width ◽  
Cell Ratio ◽  
Subclinical Marker

SUMMARY Obesity, diabetes and hypertension are risk factors for cardiovascular diseases (CVD) because they promote a state of hypercoagulability. It is known that platelets play an important role in the development of atherosclerosis. Recent studies have evaluated platelet volume indexes (PVIs) in individuals with risk factors for CVD to better understand the platelet mechanisms involved in their development. The IVPs indirectly estimate platelet function and are easily obtained from automated hematology analyzers, which provide platelet counts, mean platelet volume (MPV), platelet distribution width (PDW) and the platelet-large cell ratio (P-LCR). The present study aims to review literature studies that investigated the association between PVIs and obesity, diabetes, and arterial hypertension, in order to evaluate its use as a potential subclinical marker of CVD. Studies have shown promising results for MPV, an index that allows for early detection of platelet activation and may be useful in identifying patients before the onset of CVD development so that preventive strategies can be implemented. The PDW, although evaluated by a smaller number of studies, also showed promising results. However, there is still a long way to go in order for the MPV and PDW to be used in clinical practice, since there is still a need for more epidemiological evidence, establishing reference values, and standardizing the way results are presented.

The role of mean platelet volume and platelet distribution width in the prediction of placental abruption

2016 ◽  
Vol 36 (7) ◽  
pp. 950-953 ◽  
Author(s):  
Sefa Arlier ◽  
Cevdet Adiguzel ◽  
Esra Saygili Yilmaz ◽  
Sevtap Seyfettinoglu ◽  
Caglar Helvacioglu ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Placental Abruption ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width

scholarly journals Evaluation of the diagnostic performance of platelet-derived indices for the differential diagnosis of thrombocytopenia in pediatrics

2015 ◽  
Vol 62 (4) ◽  
pp. 547-552
Author(s):  
Nelson Hernando Aponte Barrios ◽  
Adriana Linares Ballesteros ◽  
Isabel Cristina Sarmiento Urbina ◽  
Gloria Inés Uribe Botero
Keyword(s):  
Differential Diagnosis ◽  
Acute Leukemia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Immune Thrombocytopenic Purpura ◽  
Pediatric Patients ◽  
Area Under The Curve ◽  
Large Cell ◽  
Thrombocytopenic Purpura ◽  
Distribution Width ◽  
Cell Ratio

<p>Background. Platelet-derived indices have a well-established correlation with the differential diagnosis of thrombocytopenia in adult-based research. These indices include mean platelet volume, platelet distribution width, and platelet-large cell ratio.</p><p>Objective. To determine the values of platelet-derived indices in a pediatric population with diagnoses of thrombocytopenia and their etiologic correlation.</p><p>Materials and methods. Analytic observational diagnostictest study. The population for this analytical study was pediatric patients between 6 months and 18 years of age who had thrombocytopenia (&lt;100x109/L). The study period was 18 months long.</p><p>Results. Of 54 subjects, 18 (33.3%) were diagnosed with idiopathic thrombocytopenic purpura, and 36 (66.7%) were diagnosed with acute leukemia. Mean age was 7.4 years and 6.8 years for immune thrombocytopenic purpura and acute leukemia, respectively. Mean platelet distribution width values for immune thrombocytopenic purpura and acute leukemia were 15.08 fL and 10.73, respectively. Mean MPV for immune thrombocytopenic purpura and acute leukemia was 11.7 fL and 9.8 fL, respectively. Mean platelet-large cell ratio was 38.26% and 24.97% for idiopathic thrombocytopenic purpura and acute leukemia, respectively. Differences in these three distinct platelet indices between idiopathic thrombocytopenic purpura and acute leukemia were statistically significant (p=0.00). The area under the ROC curve for platelet-derived indices showed that they were adequate for defining the causes of thrombocytopenia. MPV and platelet-large cell ratio had an area under the curve of 0.89 and 0.88, respectively, while platelet size deviation width had an area under the curve of 0.903.</p><p>Conclusions. Platelet-derived indices could be useful in the initial approach for the differential diagnosis of pediatric patients with thrombocytopenia.</p>

scholarly journals Role of mean platelet volume (MPV), platlet distribution width (PDW) and platelet large cell ratio (PLCR) in diagnosis of hyperdestructive thrombocytopenia.

2019 ◽  
Vol 26 (08) ◽  
pp. 1266-1271
Author(s):  
Hamzullah Khan ◽  
Adnan Masood ◽  
Fazle Bari ◽  
Naila Tabassum ◽  
Ameezullah
Keyword(s):  
Bone Marrow ◽  
Mean Platelet Volume ◽  
Megaloblastic Anemia ◽  
Large Cell ◽  
Prognostic Indicators ◽  
Platelet Volume ◽  
Distribution Width ◽  
Cell Ratio ◽  
Platelet Indices ◽  
Study Results

Thrombocytopenia has been shown to have significant mortality if ignored. Platelet indices have been reported to be useful prognostic indicators. The objectives of this study was to determine the diagnostic importance of the platelet indices in diagnosis of hyperdestructive thrombocytopenia i.e ITP. Study Design: Cross sectional observational study. Setting: Department of Pathology (MTI) Qazi Hussain Ahmed Medical Comeplex Nowshera Medical College. Period: Aug 2017 to Jan 2018. Materials and Methods: These blood samples were analyzed in clinical Pathology laboratory of QHAMC. Required information’s were recorded on predesigned proforrma as per objectives of the study. Results: The peripheral smears of 139 cases were reported in the study. Detailed history and Thorough clinical examination was conducted. Mean age of the study population of the patients with standard deviation was 30.90(±6.4) years. Mean platelet count was 27. 37(±12.8) x109/. Mean platelet volume MPV was 11.4(±1.4) fl. Mean platelet distribution width (PDW) was 15.4(±3.3) fl. Mean platelet large cell ratio (PLCR) was 39.6(±8.9) %. Eight cases with MPV lower than 11fl and cases with PDW more than 15fl that were also having pancytopenia or bycytopenic picture were advised bone marrow aspiration for further diagnosis if clinically indicated. Six cases out of eight to whom bone marrow was advised were sent for bone marrow examination by the clinicians and we found that three of them were idiopathic thrombocytopenia and one Megaloblastic anemia, one case with pancytopenia due to hyperspleenism and one with acute leukemia with eosinophilia. Conclusion: From the above we concluded that all cases with MPV>11fl and PDW>14fl are sensitive and specific indicators for ITP and These indices help to distinguish hyper-destructive thrombocytopenia and hypo-productive thrombocytopenia very easily and it is also cost effective on a very simple test that is special smear. We must look for platelet indices very keenly while reporting a case with bi-cytopenia and pancytopenia.

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