Pulmonary sarcomatoid carcinoma - pathohistological and immunohistochemical analysis, prognosis and complex treatment

The pulmonary sarcomatoid carcinoma (PSC) is extremely rarely lung neoplasm. A woman at the age of 55 with a local advanced pulmonary sarcomatoid carcinoma of the right lung and CT data on bilateral adrenal metastases and three brain metastases were established. Diagnosis is placed after bronchoscopy with biopsy and detailed pathochistological and immunohistochemical analysis. PSC is extremely malignant and with high risk of distant haematogenic metastases. This rare clinical case support the need for strict pathohistological and immunohistochemical analysis, a difficult pathohistological differential diagnosis with other primary malignant lung tumors and the assessment of complex treatment. In order to improve the healing results and survival of patients, timely diagnosis is required at early stage with surgical treatment and subsequent adjuvant chemotherapy and targetеd therapy after genetic analysis of surgery or biopsy tissue material.

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Early CT imaging markers of COVID-19 progression

10.21203/rs.3.rs-23851/v1 ◽

2020 ◽

Author(s):

Yanqing Chen ◽

Ningning Tang ◽

Zhao Fu ◽

Youyong Wei ◽

Longbai Ma ◽

...

Keyword(s):

Early Recognition ◽

Early Stage ◽

Multivariate Logistic Regression Analysis ◽

Lower Lobe ◽

Older Age ◽

Treatment Regimens ◽

Early Markers ◽

Risk Of Progression ◽

Ct Data ◽

The Right

Abstract Background: Early recognition of patients who are prone to develop severe or critical COVID-19 pneumonia may improve its management and modify its outcome by better treatment regimens.Objective: To investigate Computed Tomography (CT)-based early markers of COVID-19 progression. Material and methods: Thirty-two COVID-19 patients were retrospectively enrolled, including 23 moderate cases who remained moderate until being cured and discharged from hospital, and 9 progressive cases who started with moderate pneumonia and later progressed to severe or critical pneumonia. Clinical and CT data in the early course of disease were reviewed and compared. The association between early features and progression of COVID-19 were analyzed. Results: The multivariate logistic regression analysis revealed that the progression of COVID-19 were significantly associated with older age and higher CT score of the right lower lobe in the early CT images. After adjustment for relevant covariates, the relationship between CT score of the right lower lobe and COVID-19 progression persisted (odds ratio 19.28, 95% confidence interval 1.07 - 348.34).Conclusions: Higher CT Score of the right lower lobe in early images and older age appeared to be promising biomarkers for early prediction of COVID-19 prognosis. Extensive involvement of the right lower lobe at the early stage may suggest a high risk of progression.

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Resection of pulmonary sarcomatoid carcinoma metastasized to the right ventricle

Journal of Cardiac Surgery ◽

10.1111/jocs.14535 ◽

2020 ◽

Vol 35 (5) ◽

pp. 1108-1109 ◽

Cited By ~ 1

Author(s):

Claudia L Cote ◽

Mathieu Castonguay ◽

Roger Baskett

Keyword(s):

Right Ventricle ◽

Sarcomatoid Carcinoma ◽

Pulmonary Sarcomatoid Carcinoma ◽

The Right

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A jéghegy csúcsa: multiplex faggyúmirigy-eredetű bőrtumor coloncarcinomában. Muir–Torre-szindróma

Orvosi Hetilap ◽

10.1556/650.2015.30165 ◽

2015 ◽

Vol 156 (24) ◽

pp. 979-984

Author(s):

Gyula Herr ◽

Mária Szenes ◽

Györgyi Hohl ◽

Márta Erzsébet Vinkler ◽

György Tüske ◽

...

Keyword(s):

Colorectal Cancer ◽

Early Stage ◽

Immunohistochemical Analysis ◽

Right Hemicolectomy ◽

Sebaceous Carcinoma ◽

Diagnostic Methods ◽

Definitive Treatment ◽

History Of ◽

Mutl Homolog 1 ◽

The Right

Muir–Torre syndrome is a rare genodermatosis with autosomal dominant inheritance. The syndrome is considered to be a subtype of the hereditary nonpolyposis colorectal cancer (or Lynch-syndrome). In two-third of the cases, it develops as the consequence of germline mutations in mismatch-repair genes – most commonly MutS Homolog-2 and MutL Homolog-1. Its diagnosis can be established if at least one sebaceous tumor (sebaceoma, sebaceous adenoma, epithelioma, carcinoma or basal-cell carcinoma with sebaceous differentiation) and/or keratoacanthoma and at least one internal neoplasm are present. Here the authors present the history of a 52-year-old man with multiple sebaceous carcinomas on his back. Immunohistochemical analysis showed the lack of MutL Homolog-1 protein expression in the tumor cells. Detailed clinical workup in order to identify internal malignancy found malignant coecum tumor. Histopathological evaluation of the sample from the right hemicolectomy revealed mid-grade adenocarcinoma with MutL Homolog-1 and postmeiotic segregation increased-2 deficiency. The detection of the cutaneous sebaceous carcinoma and the application of the modern diagnostic methods resulted in identification of the associated colorectal cancer in an early stage; hence, definitive treatment was available for the patient. Orv. Hetil., 2015, 156(24), 979–984.

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Gingival metastasis of a mediastinal pulmonary sarcomatoid carcinoma: a case report

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-019-0991-y ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 1

Author(s):

Zhonghua Qin ◽

Bin Huang ◽

Guiping Yu ◽

Yongqiang Zheng ◽

Ke Zhao

Keyword(s):

Sarcomatoid Carcinoma ◽

Posterior Mediastinum ◽

Diagnostic Dilemma ◽

Ki 67 ◽

Case Presentation ◽

Gingival Metastasis ◽

Pulmonary Sarcomatoid Carcinoma ◽

Tumor Metastases ◽

Rare Malignancy ◽

The Right

Abstract Background Pulmonary sarcomatoid carcinoma (PSC) is a rare malignancy with both epithelial and sarcoma components, and high tumor metastasis potential. Case presentation A 63-year-old male patient had a tumor in the right posterior mediastinum, and was eventually diagnosed with PSC and gingival metastasis. The patient underwent thoracoscopic right upper pneumonectomy with lymph node dissections, and the subsequent gingival biopsy revealed a metastatic PSC. The immunohistochemistry revealed that both PSC site tissues were positive for vimentin, CKAE1/AE3 and Ki-67. The patient received radiotherapy and chemotherapy after surgery, and deceased two months later due to systemic tumor metastases. Conclusion PSC metastasis is variable, and leads to diagnostic dilemma or erroneous diagnosis. A differential diagnosis can help to distinguish it from gingival cancer.

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Immunohistochemical analysis of NANOG expression and epithelial-mesenchymal transition in pulmonary sarcomatoid carcinoma

Oncology Letters ◽

10.3892/ol.2017.5864 ◽

2017 ◽

Vol 13 (5) ◽

pp. 3695-3702 ◽

Cited By ~ 3

Author(s):

Takeshi Tamaki ◽

Toshiki Shimizu ◽

Maiko Niki ◽

Michiomi Shimizu ◽

Tohru Nishizawa ◽

...

Keyword(s):

Epithelial Mesenchymal Transition ◽

Sarcomatoid Carcinoma ◽

Immunohistochemical Analysis ◽

Mesenchymal Transition ◽

Nanog Expression ◽

Pulmonary Sarcomatoid Carcinoma

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CLINICAL CASE OF A MALIGNANT PECOMA OF THE LUNG

Problems in oncology ◽

10.37469/0507-3758-2019-65-5-756-759 ◽

2019 ◽

Vol 65 (5) ◽

pp. 756-759

Author(s):

Mikhail Postolov ◽

Nadezhda Kovalenko ◽

K. Babina ◽

Stanislav Panin ◽

Yelena Levchenko ◽

...

Keyword(s):

Good Condition ◽

Lung Neoplasm ◽

Rare Condition ◽

Epithelioid Cell ◽

X Ray ◽

Perivascular Epithelioid Cell ◽

Mesenchymal Neoplasm ◽

Preoperative Ct ◽

Lymph Duct ◽

The Right

Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm characterized by expression of both mela-nocytic and smooth muscle markers. Only 10 primary malignant lung PEComas have been reported up to date. We report a 59-year-old male who presented with a lung neoplasm, found during the routine X-ray examination. Preoperative CT-scan revealed the 3,5-cm-sized mass, located at the border of the upper, middle and lower lobes of the right lung. Patient underwent a thoracotomy, resection of the upper, middle and lower lobes of the right lung accompanied with mediastinal lymphadenectomy. After surgery, chylothorax was revealed. Conservative treatment was unsuccessful, so we performed laparoscopic clipping of the thoracic lymph duct. Patient was dismissed from hospital on the 10-th day after the second operation in good condition. In this report, we intend to increase the limited knowledge relating to natural history and optimal treatment of such a rare condition as a primary malignant lung PEComa.

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The diagnosis of early pneumoconiosis in dust-exposed workers: comparison of chest radiography and computed tomography

Acta Radiologica ◽

10.1177/02841851211022501 ◽

2021 ◽

pp. 028418512110225

Author(s):

Hideyuki Hayashi ◽

Kazuto Ashizawa ◽

Masashi Takahashi ◽

Katsuya Kato ◽

Hiroaki Arakawa ◽

...

Keyword(s):

Computed Tomography ◽

Chest Radiography ◽

Pulmonary Emphysema ◽

Early Stage ◽

Pathological Changes ◽

Occupational History ◽

Exposed Workers ◽

History Of ◽

Ct Data ◽

Positive Results

Background Chest radiography (CR) is employed as the evaluation of pneumoconiosis; however, we sometimes encounter cases in which computed tomography (CT) is more effective in detecting subtle pathological changes or cases in which CR yields false-positive results. Purpose To compare CR to CT in the diagnosis of early-stage pneumoconiosis. Material and Methods CR and CT were performed for 132 workers with an occupational history of mining. We excluded 23 cases of arc-welder’s lung. Five readers who were experienced chest radiologists or pulmonologists independently graded the pulmonary small opacities on CR of the remaining 109 cases. We then excluded 37 cases in which the CT data were not sufficient for grading. CT images of the remaining 72 cases were graded by the five readers. We also assessed the degree of pulmonary emphysema in those cases. Results The grade of profusion on CR (CR score) of all five readers was identical in only 5 of 109 cases (4.6%). The CR score coincided with that on CT in 40 of 72 cases (56%). The CT score was higher than that on CR in 13 cases (18%). On the other hand, the CT score was lower than that on CR in 19 cases (26%). The incidence of pulmonary emphysema was significantly higher in patients whose CR score was higher than their CT score. Conclusion CT is more sensitive than CR in the evaluation of early-stage pneumoconiosis. In cases with emphysema, the CR score tends to be higher in comparison to that on CT.

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Primary Small Intestinal Sarcomatoid Carcinoma: Report of a Rare Case and Literature Review

Case Reports in Oncology ◽

10.1159/000514145 ◽

2021 ◽

pp. 538-544

Author(s):

Nozomi Karakuchi ◽

Senichiro Yanagawa ◽

Kei Kushitani ◽

Shinya Kodama ◽

Yukio Takeshima ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Early Stage ◽

Vena Cava ◽

Sarcomatoid Carcinoma ◽

Additional Treatment ◽

Intestinal Tumors ◽

Gastrointestinal Malignancies ◽

Node Metastasis ◽

Small Intestinal

Sarcomatoid carcinoma (SC) is a rare malignant tumor with properties of both epithelial and mesenchymal carcinomas. SC has been reported in various organs, but the number of reports for each type is small. Small intestinal tumors make up about 3–6% of gastrointestinal malignancies. Discovering them in the early stage is rare and difficult, with anemia and/or abdominal pain as the major symptoms of small intestinal tumors. Primary small intestinal SC (SISC) is rare among small intestinal tumors, and currently very few cases have been reported in the literature. Previous studies have reported that neither chemotherapy nor radiotherapy improves the overall survival rate of patients with SISC, and the prognosis is extremely poor. Currently, surgical resection remains the only optimal therapeutic approach for SISC. Here, we present the case of a 90-year-old woman who had acute peritonitis due to perforation of a small intestinal tumor. She underwent emergency exploratory laparotomy and partial resection of the small intestine, including the tumor. The tumor was pathologically identified as a primary SISC with mesenteric lymph node metastasis. Subsequently, she had recurrence in the intra-abdominal area and lymph node metastasis anterior to the inferior vena cava and died 15 months after surgery without any additional treatment.

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