scholarly journals Effect of drug-induced pathomorphosis on oral cavity organs and tissues in chronic obstructive pulmonary disease combined with coronary heart disease: A clinical case

2021 ◽  
Vol 8 (1) ◽  
pp. 4197-4202
Author(s):  
Nataliya Emelyanova ◽  
Irina Komir
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Clinical Case ◽  
Mutual Influence ◽  
Chronic Obstructive ◽  
Drug Induced ◽  
Obstructive Pulmonary Disease

This article describes a clinical case of a patient, as well as literature data confirming the direct mutual influence of lesions in the oral cavity and the bronchocardiac complex pathology. Special attention is paid to the side effects of the main drugs prescribed in the basic therapy of chronic obstructive pulmonary disease, combined with coronary heart disease. It is noted that the drug-induced pathomorphosis can cause the development of periodontal lesions. Insufficient knowledge of these issues and the practical need for corrective measures to be taken by dentists with this category of patients warrant the relevance of research in this direction.

scholarly journals THE PECULIARITIES OF THE COMBINED COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CORONARY HEART DISEASE (LITERATURE REVIEW)

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Т.О. Ilashchuk ◽  
O.P. Mykytyuk ◽  
Y.V. Chobanu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pulmonary Disease ◽  
Therapeutic Strategies ◽  
Data Sources ◽  
Chronic Obstructive ◽  
Physiological Effects ◽  
Obstructive Pulmonary Disease ◽  
Promising Area

The aim – to analyze the literature data sources concerning the peculiarities of thecombined course of chronic obstructive pulmonary disease (COPD) and coronaryheart disease (CHD), taking into account the endothelial dysfunction of systemicinflammation and oxidative stress.Conclusions. The main mechanisms involved in the progression of the combinedcourse of chronic obstructive pulmonary disease and coronary heart disease are theendothelial dysfunction, the systemic inflammation and desynchronosis. The pleiotropiceffects and diverce molecular interactions of sirtuins have distinct physiological effects,such as preventing the development and progression of emphysema in COPD and avoiding the progression of myocardical hypertrophy and heart failure. The researchof intermolecular interactions with the help of Sirtuin is a promising area for findingnew effective diagnostic and prognostic criteria and therapeutic strategies for COPDand CVD.

scholarly journals Developing and validating a nomogram for prediction coronary heart disease in patients with chronic obstructive pulmonary disease

2021 ◽  
Author(s):  
Yun Yu ◽  
Xiao-Xian Cai ◽  
Jun-Lin Chen ◽  
Jing-song Xu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pulmonary Disease ◽  
Area Under The Curve ◽  
Chronic Obstructive ◽  
Discriminative Ability ◽  
Internal Validation ◽  
Obstructive Pulmonary Disease ◽  
Clinical Applicability

Abstract Background Previous studies indicate that there is an association between chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). Herein,we established and further validated a novel nomogram for predicting CHD in patients with COPD. Methods In total,we assessed 421 patients with COPD admitted in the Second Affiliated Hospital of Nanchang University between January 2017 to August 2019 .Univariate and multivariate analyses were used to develop a nomogram model containing variables which we screened,testing the discriminative ability and calibration of the nomogram by C-index,area under the curve(AUC) and calibration plots. Decision curve analysis was applied to evaluate the benefit of the screeing model.Further, we conducted an internal validation by using the bootstrapping validation. Results Multivariate analysis shows that arterial thrombosis,prealbumin,albumin and estimated glomerular filtration rate are independent factors in predicting the risk of CHD.The prediction model exhibited discriminative ability with a C-index of 0.882 (95% CI: 0.848–0.916), and the AUC at 0.878(95% CI: 0.843–0.913).The nomogram demonstrated efficient calibration and clinical applicability when deciding on interventions with a CHD possibility threshold of 7% .During the interval validation, it could still attain a C-index value of 0.869. Conclusion The nomogram can predict the risk of CHD in patients with COPD,with a high discriminative ability and potential clinical applicability.

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