Congenital Cardiovascular Anomalies in Twins

PEDIATRICS ◽  
1960 ◽  
Vol 25 (1) ◽  
pp. 20-20
Author(s):  
S. G.
Keyword(s):  
New York ◽  
Congenital Heart Disease ◽  
New York City ◽  
Heart Disease ◽  
Congenital Heart ◽  
Clinical Investigation ◽  
Monozygotic Twins ◽  
Dizygotic Twins ◽  
Genetic And Environmental Factors ◽  
Cardiovascular Anomalies

This paper reports on a very carefully conducted clinical investigation of the etiologic factors involved in cardiovascular anomalies in twins. The author studied 37 pairs of twins in whom congenital heart disease was known to be present in at least one member of the pair. The patients were selected from several clinics in New York City; only those pairs of twins were chosen for whom the zygosity could be definitely determined and the presence or absence of a cardiovascular anomaly established. There were 26 pairs of dizygotic twins and 11 pairs of monozygotic twins in the study. Two pairs in each group were concordant (both co-twins affected) for the presence of cardiovascular anomalies; all other pairs were discordant (only one twin had congenital heart disease). The relative etiologic significance of genetic and environmental factors is discussed in the light of these observations.

Coarctation of the aorta in dizygotic twins

2000 ◽  
Vol 10 (1) ◽  
pp. 46-48 ◽  
Author(s):  
Monica Caldas ◽  
Rami Dhillon
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Environmental Factors ◽  
Congenital Heart ◽  
Monozygotic Twins ◽  
Coarctation Of The Aorta ◽  
In Vitro Fertilisation ◽  
Dizygotic Twins ◽  
Genetic And Environmental Factors

AbstractThe incidence of congenital heart disease is higher in monozygotic than dizygotic twins, with a higher concordance rate. Although coarctation of the aorta has previously been reported in monozygotic twins, to the best of our knowledge it has not been described in dizygotic twins. We report here such a concurrence in dizygotic twins conceived by in-vitro fertilisation. The finding provides support for both genetic and environmental factors in the aetiology of congenital heart disease. Furthermore, it highlights our lack of data regarding the outcome of in-vitro fertilisation.

scholarly journals Impact of Coronavirus Disease 2019 (COVID‐19) on Patients With Congenital Heart Disease Across the Lifespan: The Experience of an Academic Congenital Heart Disease Center in New York City

2020 ◽  
Vol 9 (23) ◽  
Author(s):  
Matthew J. Lewis ◽  
Brett R. Anderson ◽  
Michael Fremed ◽  
Melissa Argenio ◽  
Usha Krishnan ◽  
...  
Keyword(s):  
New York ◽  
Congenital Heart Disease ◽  
New York City ◽  
Heart Disease ◽  
York City ◽  
Congenital Heart ◽  
Severe Infection ◽  
Genetic Syndrome ◽  
Physiological Stage ◽  
The Impact

Background We sought to assess the impact and predictors of coronavirus disease 2019 (COVID‐19) infection and severity in a cohort of patients with congenital heart disease (CHD) at a large CHD center in New York City. Methods and Results We performed a retrospective review of all individuals with CHD followed at Columbia University Irving Medical Center who were diagnosed with COVID‐19 between March 1, 2020 and July 1, 2020. The primary end point was moderate/severe response to COVID‐19 infection defined as (1) death during COVID‐19 infection; or (2) need for hospitalization and/or respiratory support secondary to COVID‐19 infection. Among 53 COVID‐19‐positive patients with CHD, 10 (19%) were <18 years of age (median age 34 years of age). Thirty‐one (58%) had complex congenital anatomy including 10 (19%) with a Fontan repair. Eight (15%) had a genetic syndrome, 6 (11%) had pulmonary hypertension, and 9 (17%) were obese. Among adults, 18 (41%) were physiologic class C or D. For the entire cohort, 9 (17%) had a moderate/severe infection, including 3 deaths (6%). After correcting for multiple comparisons, the presence of a genetic syndrome (odds ratio [OR], 35.82; P =0.0002), and in adults, physiological Stage C or D (OR, 19.38; P =0.002) were significantly associated with moderate/severe infection. Conclusions At our CHD center, the number of symptomatic patients with COVID‐19 was relatively low. Patients with CHD with a genetic syndrome and adults at advanced physiological stage were at highest risk for moderate/severe infection.

Twins and Congenital Heart Disease

1961 ◽  
Vol 10 (04) ◽  
pp. 443-456 ◽  
Author(s):  
Maurice Campbell
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformation ◽  
Genetic Predisposition ◽  
Congenital Heart ◽  
Monozygotic Twins ◽  
The Other ◽  
Unpublished Paper ◽  
Dizygotic Twins ◽  
Foetal Circulation

Summary and Conclusions The number of twins in 942 families where the propositus had a congenital malformation of the heart has been studied. The 38 pairs were not significantly more than could be expected by chance: nor were the 21 pairs where one member had a malformation of the heart. In 16 pairs, one was affected and the other normal; and in 5 pairs, one was affected and the other unknown. In 2 pairs, both were unknown because of early deaths; and in 15, both members of the pair were normal. In no pair were both members known to be affected. There is clear evidence from this series and from the series of Uchida and Rowe (1957) and of Lamy et al. (1957) that where one member of a pair of monozygotic twins has a congenital malformation of the heart, the other is generally normal. It is the exception rather than the rule for both members to be affected, though several examples of such pairs have been reported. There is some evidence from these three series that monozygotic twins are more liable to have a malformation of the heart than dizygotic twins and their sibs. It follows from these two findings, that the immediate cause of the malformation of the heart must be environmental, though probably there is some genetic predisposition. A disturbance of the foetal circulation to the affected twin because of a single placenta and chorion seems to be the most likely environmental cause. I should like to thank Professor Gedda of Rome and Professor Polani for their helpful suggestions and Dr. I. E. Evans for letting me see his unpublished paper on the evidence for monozygosity in some of the pairs of twins included in this paper.

CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1950 ◽  
Vol 6 (2) ◽  
pp. 299-304
Author(s):  
STANLEY GIBSON
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Private Practice ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Pediatric Practice ◽  
Medical Centers ◽  
Additional Burden ◽  
Cardiac Diagnosis ◽  
Cardiovascular Anomalies

A short while ago, I asked a busy pediatrician of long experience how many "blue babies" he had seen in the course of his practice. He thought for a moment, then replied, "Four." Since that time I have made several other inquiries among my pediatric associates and have been surprised to find how small a number of cases of congenital heart disease they have had in their private practice. Yet if some stranger from another planet should visit Dr. Taussig's clinic, he might well conclude that congenital heart disease is as frequent as measles. The concentration of cases in a few medical centers throughout the country has doubtless given a false impression of the frequency and importance of congenital malformations of the heart. If then the problem represents so small a portion of general pediatric practice, one may fairly ask whether the already overworked children's specialist should undertake an additional burden. He is apt, too, to be discouraged when he contemplates some of the special technics and gadgets which have become popular in cardiac diagnosis. Let me hasten to assure him that his feeling of frustration is no more acute than that of many of us of the older generation when some of our chemical pediatricians begin to toss their atomic weights around and overwhelm us with millimols and milliequivalents. I wish, however, to emphasize the fact that it requires very little time and effort to have a good working knowledge of the diagnosis of most of the congenital cardiovascular anomalies which lend themselves to correction or improvement by surgical means.

scholarly journals Long‐Term Outcome of Patients With Congenital Heart Disease Undergoing Cardiac Resynchronization Therapy

2021 ◽  
Author(s):  
Peter Kubuš ◽  
Jana Rubáčková Popelová ◽  
Jan Kovanda ◽  
Kamil Sedláček ◽  
Jan Janoušek
Keyword(s):  
New York ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Association ◽  
Cardiac Resynchronization ◽  
New York Heart Association ◽  
Crt Response

Background Cardiac resynchronization therapy (CRT) is rarely used in patients with congenital heart disease, and reported follow‐up is short. We sought to evaluate long‐term impact of CRT in a single‐center cohort of patients with congenital heart disease. Methods and Results Thirty‐two consecutive patients with structural congenital heart disease (N=30) or congenital atrioventricular block (N=2), aged median of 12.9 years at CRT with pacing capability device implantation, were followed up for a median of 8.7 years. CRT response was defined as an increase in systemic ventricular ejection fraction or fractional area of change by >10 units and improved or unchanged New York Heart Association class. Freedom from cardiovascular death, heart failure hospitalization, or new transplant listing was 92.6% and 83.2% at 5 and 10 years, respectively. Freedom from CRT complications, leading to surgical system revision (elective generator replacement excluded) or therapy termination, was 82.7% and 72.2% at 5 and 10 years, respectively. The overall probability of an uneventful therapy continuation was 76.3% and 58.8% at 5 and 10 years, respectively. There was a significant increase in ejection fraction/fractional area of change ( P <0.001) mainly attributable to patients with systemic left ventricle ( P =0.002) and decrease in systemic ventricular end‐diastolic dimensions ( P <0.05) after CRT. New York Heart Association functional class improved from a median 2.0 to 1.25 ( P <0.001). Long‐term CRT response was present in 54.8% of patients at last follow‐up and was more frequent in systemic left ventricle ( P <0.001). Conclusions CRT in patients with congenital heart disease was associated with acceptable survival and long‐term response in ≈50% of patients. Probability of an uneventful CRT continuation was modest.

scholarly journals Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease

BMC Genomics ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Guoliang Lyu ◽  
Chao Zhang ◽  
Te Ling ◽  
Rui Liu ◽  
Le Zong ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Monozygotic Twins

Twins

2019 ◽  
pp. 25-30
Author(s):  
Robin D. Clark ◽  
Cynthia J. Curry
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Birth Defects ◽  
Congenital Heart ◽  
Clinical Case ◽  
Monozygotic Twins ◽  
Perinatal Complications ◽  
Case Presentation ◽  
Incidence Risk

This chapter reviews the incidence, risk factors, and epidemiology of disorders associated with twinning. The timing of twinning and the types of twins are reviewed. The fetal and perinatal complications of twinning including twin to twin transfusion and its treatment are discussed, as well as the possible consequences of death of a monozygotic co-twin. These include severe disruptive brain abnormalities, and other vascular disruptive defects. The birth defects more common in twins are enumerated and specific patterns of birth defects such as hemifacial macrosomia and VACTERL are discussed. A clinical case presentation features monozygotic twins with twin-to-twin transfusion syndrome and congenital heart disease.

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