Meconium Aspiration and Tolazoline

PEDIATRICS ◽  
1978 ◽  
Vol 62 (1) ◽  
pp. 124-124
Author(s):  
Gabriel Duc
Keyword(s):  
Newborn Infants ◽  
Antibacterial Prophylaxis ◽  
Meconium Aspiration ◽  
Practical Consequence ◽  
Pharmacologic Agents ◽  
Modern Era

In days gone by, therapists had a limited number of medications (principally, harmless decoctions) to choose from. Under these circumstances, untested proclamations concerning treatment with these medications were of little practical consequence to patients. In the modern era of powerful pharmacologic agents, the situation is different. Unevaluated proposals for therapy (such as antibacterial prophylaxis using sulfisoxazole or chloramphenicol, or oxygen for newborn infants) have had tragic results. Therefore, it is disturbing to find an example of untested advice in a highly respected and widely circulated textbook of pediatrics.

AIDS and Suctioning Newborn Infants

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 520-521
Author(s):  
PAUL M. KEMPEN
Keyword(s):  
Endotracheal Tube ◽  
Endotracheal Intubation ◽  
Negative Pressure ◽  
Newborn Infants ◽  
Upper Airway ◽  
Suction Catheter ◽  
Meconium Aspiration ◽  
Endotracheal Suction ◽  
Suction Device ◽  
Recommended Therapy

To the Editor.— The current recommended therapy for patients with meconium aspiration consists of extensive suctioning of the oropharynx and nasopharynx after delivery of the head, with subsequent endotracheal intubation and deep suction with the endotracheal tube as the suction catheter. The upper airway is commonly cleared with a bulb syringe and/or a Delee suction device. With both the Delee and the currently recommended endotracheal suction methods, the physician's mouth is the source of negative pressure.

ADJUSTMENT OF VENTILATION AND PERFUSION IN THE FULL-TERM NORMAL AND DISTRESSED NEONATE AS DETERMINED BY URINARY ALVEOLAR NITROGEN GRADIENTS

PEDIATRICS ◽  
1971 ◽  
Vol 47 (5) ◽  
pp. 865-869
Author(s):  
A. N. Krauss ◽  
J. A. Soodalter ◽  
P. A. M. Auld
Keyword(s):  
Normal Distribution ◽  
Pulmonary Ventilation ◽  
Newborn Infants ◽  
Term Infant ◽  
Full Term ◽  
Normal Range ◽  
Meconium Aspiration ◽  
Large Gradient ◽  
Almost All ◽  
Ventilation And Perfusion

The urinary alveolar nitrogen gradient was measured serially in 20 normal and six distressed full-term newborn infants. When the gradient is small (less than 10 mm Hg) ventilation is evenly distributed throughout the lung. When a large gradient is determined this is a reflection of numbers of alveoli with low ventilation-perfusion (VA/Q) ratios. In healthy adults used as a control for the method, a gradient of less than 10 mm Hg was recorded. Healthy, nondistressed newborn infants were almost all within the normal range from the first day of life. Infants found to have distress due to meconium aspiration or transient neonatal tachypnea had large gradients throughout the first week of life. The studies indicate that the healthy, full-term infant rapidly achieves a normal distribution of pulmonary ventilation, whereas serious maldistribution of ventilation occurs in meconium aspiration pneumonia.

An Investigation of the Mortality Rate and Risk Factors in Newborn Infants With Meconium Aspiration Syndrome

2016 ◽  
Vol 7 (3) ◽  
Author(s):  
Mohammad Kazem Sabzehei ◽  
Behnaz Basiri ◽  
Maryam Shokouhi ◽  
Mohammad Hossein Eslamian ◽  
Zahra Razavi
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Newborn Infants ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration

Coproporphyrin in urine of newborns with meconium aspiration syndrome.

1983 ◽  
Vol 29 (12) ◽  
pp. 2054-2056 ◽  
Author(s):  
J Francoual ◽  
A Lindenbaum ◽  
M Dehan ◽  
H de Verneuil ◽  
Y Nordmann ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Thin Layer ◽  
High Performance ◽  
Newborn Infants ◽  
Meconium Aspiration Syndrome ◽  
Spectrophotometric Analysis ◽  
Partial Purification ◽  
Meconium Aspiration ◽  
Urinary Coproporphyrin

Abstract We evaluated coproporphyrin in the first urine passed by newborn infants with and without meconium aspiration, by spectrophotometric analysis and thin-layer and "high-performance" liquid chromatography. Urines of newborn infants without meconium aspiration contained only very small quantities of coproporphyrin, detected, after partial purification, by "high-performance" liquid chromatography. Urines of newborn infants with meconium aspiration contained large quantities of coproporphyrin, identified by all three techniques. Urinary coproporphyrin as measured spectrophotometrically correlates well with the "urinary meconium index," and the method is simple, rapid, and reliable, even for samples containing hemoglobin.

Newborn Infants of Tuberculous Mothers, Further Comment

PEDIATRICS ◽  
1969 ◽  
Vol 43 (2) ◽  
pp. 303-304
Author(s):  
Sanford N. Cohen ◽  
Wendell W. Weber
Keyword(s):  
Newborn Infant ◽  
Recent Article ◽  
Newborn Infants ◽  
Great Care ◽  
Hepatic Enzyme ◽  
Pharmacologic Agents ◽  
Inh Prophylaxis

In their recent article, Avery and Wolfsdorf discussed INH prophylaxis of infants of tuberculous mothers and stated, "The unusual reactions of infants to many pharmacologic agents, with respect to absorption and excretion, have necessitated great care in matters of dosage and indications in infancy." The Committee on Drugs commented, in the same issue, that the pharmacology of INH has not been systematically studied in the newborn infant. We have been studying the characteristics of the hepatic enzyme which catalyzes the acetylation of INH and sulfonamides.

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