Relationship of Blood Pressure to Blood Lead Concentrations in Small Children

PEDIATRICS ◽  
1979 ◽  
Vol 63 (4) ◽  
pp. 674-676
Author(s):  
Ramesh C. Jhaveri ◽  
Lorenzo Lavorgna ◽  
Shiv K. Dube ◽  
Leonard Glass ◽  
Farida Khan ◽  
...  

Elevated blood lead concentrations are associated with a variety of pathophysiologic changes in both children and adults, even in the absence of clinical symptoms. Although hypertension has been described in adults with elevated blood lead concentrations,1 there have been no systematic studies in infants and children in which lead levels were correlated with blood pressure measurements. In the present study, blood lead concentrations of greater than 40 µg/dl were associated with blood pressure elevations in infants and young children. SUBJECTS AND METHODS Thirty-four patients, age 1 to 3 years, who were referred to the Special Lead Clinic of the Jewish Hospital and Medical Center of Brooklyn because of blood lead levels of more than 40 µg/dl were subjects of the study.

2006 ◽  
Vol 44 (2) ◽  
pp. 304-309 ◽  
Author(s):  
Concettina FENGA ◽  
Anna CACCIOLA ◽  
Lucia Barbaro MARTINO ◽  
Santina Ricciardo CALDERARO ◽  
Carmelina DI NOLA ◽  
...  

1996 ◽  
Vol 51 (4) ◽  
pp. 324-328 ◽  
Author(s):  
Uzi Navah ◽  
Paul Froom ◽  
Estela Kristal-Boneh ◽  
Bernard Moschovitch ◽  
Joseph Ribak

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.


Author(s):  
Florence Bodeau-Livinec ◽  
Philippe Glorennec ◽  
Michel Cot ◽  
Pierre Dumas ◽  
Séverine Durand ◽  
...  

PEDIATRICS ◽  
1996 ◽  
Vol 97 (4) ◽  
pp. 603-603
Author(s):  
Philip J. Landrigan

The article by Kimbrough et al (Pediatrics. 1995;95:550-554) concerning a survey of blood lead levels among children residing near a closed, heavily contaminated lead smelter found that 78 of 490 preschoolers (16%) had blood lead levels at or above the Centers for Disease Control and Prevention action level of 10 µg/dL. By contrast, the prevalence of elevated blood lead levels among all preschool children in the United States is 8.9%.1 Kimbrough et al found that blood lead levels were positively correlated with home dust lead levels, soil lead levels, hours of outdoor play, and levels of lead in indoor paint.


Sign in / Sign up

Export Citation Format

Share Document