Infantile Spasms Due to Unilateral Cerebral Infarcts

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1024-1026
Author(s):  
LUIS A. ALVAREZ ◽  
SHLOMO SHINNAR ◽  
SOLOMON L. MOSHÉ
Keyword(s):  
Mental Retardation ◽  
Genetic Disorders ◽  
Infantile Spasms ◽  
Seizure Disorder ◽  
Neurologic Examination ◽  
Cerebral Infarcts ◽  
Symptomatic Group ◽  
High Incidence ◽  
Underlying Disorder ◽  
Group 1

Infantile spasms are an age-specific seizure disorder that occur in infants with no known underlying disorder or prior neurologic insult (cryptogenic group) as well as in infants with a variety of genetic disorders or known prior neurologic insult (symptomatic group).1-8 The presence of infantile spasms is associated with a high incidence of developmental retardation (87%)3 even in previously normal infants.3,5-7 Although there are many contradictory studies, it is generally believed that the infants in the symptomatic group, especially those with abnormal findings on neurologic examination prior to the onset of the seizures, have a significantly higher incidence of mental retardation and epilepsy than the infants in the cryptogenic group.1-9

The Biosocial Basis OF Mental Retardation, by Sonia F. Osler and Robert E. Cooke. Baltimore: The Johns Hopkins Press, 1965, 151 pp., $5.50

PEDIATRICS ◽  
1966 ◽  
Vol 37 (6) ◽  
pp. 986-986
Author(s):  
Robert B. Kucel
Keyword(s):  
Mental Retardation ◽  
Low Income ◽  
Social Factors ◽  
Psychological Factors ◽  
Low Socioeconomic ◽  
Important Concern ◽  
The Social ◽  
High Incidence ◽  
Low Income Families ◽  
Relationship Of

With the increasing interest in mental retardation more articles, monographs, and books appear on the subject. The Biosocial Basis of Mental Retardation is a collection of seven essays originally delivered at the John Hopkins Hospital. Although pediatricians have turned their attention in mental retardation mostly to the biological components of mental retardation, there is a growing awareness that social and psychological factors also play a significant role. The interrelationship of biological and social factors is virtually an unchartered sea. The several authors who originally presented these essays are attempting to highlight some of the social factors and, where appropriate, to point out how some of the social features relate to biological ones. For example, the well known relationship of the high incidence of prematurity in low socioeconomic group families is a fact most pediatricians know but the implication of this fact as far as prevention is concerned is a large and important concern and as yet poorly understood. With the increasing amount of federal interest in programs for low income families, many pediatricians will want to become better informed about the implications. Some of these points are considered in the chapter by Janet Hardy. For the person concerned with medical remedies for mental retardation, there will be little of interest in this book. On the other hand, for those who are anxious to know more about social and psychological factors as they relate to mental retardation, this is a very useful and fascinating compendium of articles. Particularly intriguing are the articles by Eli Ginzberg who discusses the mentally handicapped in an increasingly technological society.

Oligophrenia associated with various pathogenesis

2020 ◽  
Vol 56 (07) ◽  
pp. 73-76
Author(s):  
Afat Afar Israfilova ◽  
Keyword(s):  
Mental Retardation ◽  
Key Words ◽  
Metabolic Disorders ◽  
Genetic Disorders ◽  
Physical Illness ◽  
The Body ◽  
Negative Effect

The causes of pathology are different. There are various inherited genetic disorders of the body, which are metabolic disorders, chromosome deficiency leads to various pathologies. Other factors have a negative effect on embryonic pathogenesis in the intrauterine stage. As a result, the baby does not develop properly in the womb. Key words: Pathology, physical illness, infection, mental retardation

Infantile Spasms, Hypsarhythmia, and Mental Retardation

JAMA ◽  
1962 ◽  
Vol 182 (5) ◽  
pp. 523 ◽  
Author(s):  
J. Gordon Millichap
Keyword(s):  
Mental Retardation ◽  
Infantile Spasms

Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle cell disease

Blood ◽  
2003 ◽  
Vol 101 (2) ◽  
pp. 415-419 ◽  
Author(s):  
Jessica N. Henderson ◽  
Michael J. Noetzel ◽  
Robert C. McKinstry ◽  
Desiree A. White ◽  
Melissa Armstrong ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Sickle Cell Disease ◽  
Endotracheal Intubation ◽  
Reversible Posterior Leukoencephalopathy Syndrome ◽  
Cognitive Testing ◽  
Acute Chest Syndrome ◽  
Neurologic Examination ◽  
Cell Disease ◽  
Cerebral Infarcts ◽  
Posterior Leukoencephalopathy

Patients with severe acute chest syndrome (ACS) requiring endotracheal intubation and erythrocytopheresis are at increased risk for neurologic morbidity. This study examines patients with sickle cell disease who developed severe episodes of ACS, leading to endotracheal intubation, ventilatory support for respiratory failure, and erythrocytapheresis. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) studies, a neurologic examination by a pediatric neurologist, and cognitive testing were done in all patients. Five consecutive patients, aged 3 to 9 years, were identified with severe ACS. All patients developed neurologic complications resulting from ACS episodes, including seizures (n = 2), silent cerebral infarcts (n = 3), cerebral hemorrhage (n = 2), and reversible posterior leukoencephalopathy syndrome (n = 3). Children with severe ACS should have a magnetic resonance image of the brain, neurologic examination by a neurologist, and cognitive testing to detect the presence of neurologic morbidity.

scholarly journals Infantile Spasms: Little Seizures, BIG Consequences

2006 ◽  
Vol 6 (3) ◽  
pp. 63-69 ◽  
Author(s):  
W. Donald Shields
Keyword(s):  
Mental Retardation ◽  
Seizure Control ◽  
Early Recognition ◽  
Infantile Spasms ◽  
Diagnostic Evaluation ◽  
Proper Treatment ◽  
Important Impact

Infantile spasms is one of the “catastrophic childhood epilepsies” because of the difficulty in controlling seizures and the association with mental retardation. However, early recognition, a careful diagnostic evaluation, and proper treatment may allow some children to attain seizure control and to achieve a normal, or at least much improved, level of development. Thus, there is the opportunity to have an important impact in the lives of these unfortunate children and their families.

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