Quantum cloud theory: Collapse expectations and superposition conservation

Most of metabolic processes are extremely complicated but occur spontaneously and steadily, the essential reason of which may be either a thermodynamic problem or related to some quantum properties. Here, collapse selection is interpreted with an analytical model of energy transfer, from which the concept of quantum cloud is defined as that during undetectable changes of a group of particles between its effective changes, particles are in the superposition of various energy states and the group is named as a cloud. It is deduced from a conservation notion of matter proportions that active cloud collapses have least-time expectation while passive collapses have matter-proportion expectation. As the results, quantum Zeno effect is a typical phenomenon of passive collapses while anti-Zeno effect is typical active collapses; moreover, the phenomenon of dark matter may be dark-cloud effect of normal matter while the phenomenon of accelerating universe may be induced by the luminescent asymmetries of bright celestial bodies.

The ALMA Survey of 70 μm Dark High-mass Clumps in Early Stages (ASHES). IV. Star Formation Signatures in G023.477

With a mass of ∼1000 M ⊙ and a surface density of ∼0.5 g cm−2, G023.477+0.114, also known as IRDC 18310-4, is an infrared dark cloud (IRDC) that has the potential to form high-mass stars and has been recognized as a promising prestellar clump candidate. To characterize the early stages of high-mass star formation, we have observed G023.477+0.114 as part of the Atacama Large Millimeter/submillimeter Array (ALMA) Survey of 70 μm Dark High-mass Clumps in Early Stages. We have conducted ∼1.″2 resolution observations with ALMA at 1.3 mm in dust continuum and molecular line emission. We have identified 11 cores, whose masses range from 1.1 to 19.0 M ⊙. Ignoring magnetic fields, the virial parameters of the cores are below unity, implying that the cores are gravitationally bound. However, when magnetic fields are included, the prestellar cores are close to virial equilibrium, while the protostellar cores remain sub-virialized. Star formation activity has already started in this clump. Four collimated outflows are detected in CO and SiO. H2CO and CH3OH emission coincide with the high-velocity components seen in the CO and SiO emission. The outflows are randomly oriented for the natal filament and the magnetic field. The position-velocity diagrams suggest that episodic mass ejection has already begun even in this very early phase of protostellar formation. The masses of the identified cores are comparable to the expected maximum stellar mass that this IRDC could form (8–19 M ⊙). We explore two possibilities on how IRDC G023.477+0.114 could eventually form high-mass stars in the context of theoretical scenarios.

Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution

Background: Conceived of as the “silver lining” of the dark cloud of the coronavirus disease 2019 (COVID-19) pandemic, lessons taught by this catastrophe should be leveraged by medical authorities and policy makers to optimize health care globally. A major lesson is that resilient health systems should absorb sudden shocks incited by overwhelming health emergencies without compromising the continuum of care of chronic diseases, especially of cancer. Methods: The present review dissects the association between COVID-19 and thyroid cancer (TC), especially with differentiated TC (DTC), focusing on available data, knowledge gaps, current challenges, and future perspectives. Results: Obesity has been incriminated in terms of both COVID-19 severity and a rising incidence of TC, especially of DTC. The current conceptualization of the pathophysiological landscape of COVID-19–(D)TC association implicates an interplay between obesity, inflammation, immunity, and oxidative stress. Whether COVID-19 could aggravate the health burden posed by (D)TC or vice versa has yet to be clarified. Improved understanding and harnessing of the pathophysiological landscape of the COVID-19–(D)TC association will empower a mechanism-guided, safe, evidence-based, and risk-stratified management of (D)TC in the COVID-19 era and beyond. Conclusion: A multidisciplinary patient-centered decision-making will ensure high-quality (D)TC care for patients, with or without COVID-19.

Anticancer Effects and Mechanisms of OSW-1 Isolated From Ornithogalum saundersiae: A Review

For centuries, cancer has been a lingering dark cloud floating on people’s heads. With rapid population growth and aging worldwide, cancer incidence and mortality are growing rapidly. Despite major advances in oncotherapy including surgery, radiation and chemical therapy, as well as immunotherapy and targeted therapy, cancer is expected be the leading cause of premature death in this century. Nowadays, natural compounds with potential anticancer effects have become an indispensable natural treasure for discovering clinically useful agents and made remarkable achievements in cancer chemotherapy. In this regards, OSW-1, which was isolated from the bulbs of Ornithogalum saundersiae in 1992, has exhibited powerful anticancer activities in various cancers. However, after almost three decades, OSW-1 is still far from becoming a real anticancer agent for its anticancer mechanisms remain unclear. Therefore, in this review we summarize the available evidence on the anticancer effects and mechanisms of OSW-1 in vitro and in vivo, and some insights for researchers who are interested in OSW-1 as a potential anticancer drug. We conclude that OSW-1 is a potential candidate for anticancer drugs and deserves further study.

The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases

With the continuous improvement of living standards but the lack of exercise, aging-associated metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD) are becoming a lingering dark cloud over society. Studies have found that metabolic disorders are near related to glucose, lipid metabolism, and cellular aging. Fibroblast growth factor 21 (FGF21), a member of the FGFs family, efficiently regulates the homeostasis of metabolism and cellular aging. By activating autophagy genes and improving inflammation, FGF21 indirectly delays cellular aging and directly exerts anti-aging effects by regulating aging genes. FGF21 can also regulate glucose and lipid metabolism by controlling metabolism-related genes, such as adipose triglyceride lipase (ATGL) and acetyl-CoA carboxylase (ACC1). Because FGF21 can regulate metabolism and cellular aging simultaneously, FGF21 analogs and FGF21 receptor agonists are gradually being valued and could become a treatment approach for aging-associated metabolic diseases. However, the mechanism by which FGF21 achieves curative effects is still not known. This review aims to interpret the interactive influence between FGF21, aging, and metabolic diseases and delineate the pharmacology of FGF21, providing theoretical support for further research on FGF21.

Discovery of CH2CHCCH and detection of HCCN, HC4N, CH3CH2CN, and, tentatively, CH3CH2CCH in TMC-1

We present the discovery in TMC-1 of vinyl acetylene, CH2CHCCH, and the detection, for the first time in a cold dark cloud, of HCCN, HC4N, and CH3CH2CN. A tentative detection of CH3CH2CCH is also reported. The column density of vinyl acetylene is (1.2 ± 0.2) × 1013 cm−2, which makes it one of the most abundant closed-shell hydrocarbons detected in TMC-1. Its abundance is only three times lower than that of propylene, CH3CHCH2. The column densities derived for HCCN and HC4N are (4.4 ± 04) × 1011 cm−2 and (3.7 ± 0.4) × 1011 cm−2, respectively. Hence, the HCCN/HC4N abundance ratio is 1.2 ± 0.3. For ethyl cyanide we derive a column density of (1.1 ± 0.3) × 1011 cm−2. These results are compared with a state-of-the-art chemical model of TMC-1, which is able to account for the observed abundances of these molecules through gas-phase chemical routes.