Pulmonary Function Testing in Pediatric Practice

1994 ◽  
Vol 15 (10) ◽  
pp. 403-411
Author(s):  
Gary A. Mueller ◽  
Howard Eigen

Pulmonary function testing is an important tool in the evaluation of children who have or are suspected of having lung disease. Of particular importance, pulmonary function testing provides objective and reproducible measurements, which then can be used to follow the response to therapy. The measurements of air flow and lung volumes are the mechanical pulmonary function tests used most commonly. However, measurements of the efficiency of gas exchange also are considered a test of pulmonary function and can be assessed by such methods as arterial blood gas and oximetry. This article focuses on those tests readily available to the pediatrician in the office or hospital. Measuring pulmonary function regularly is analogous to measuring blood pressure in patients who have hypertension, allowing the physician to follow a measurement directly associated with the pulmonary disease process. As with other clinical tests, pulmonary function measurements are most effective when used to answer a specific question about the patient. For example, in a child who presents having a persistent cough and a family history of asthma, the diagnosis may be asthma, and the question "Does the child have airflow obstruction consistent with asthma?" can be answered by spirometry. Spirometry The parameters commonly measured in the assessment of respiratory function are lung volumes, air flows and timed volumes, and airway reactivity.

1992 ◽  
Vol 10 (3) ◽  
pp. 459-463 ◽  
Author(s):  
E R Ellis ◽  
R B Marcus ◽  
M J Cicale ◽  
D S Springfield ◽  
F J Bova ◽  
...  

PURPOSE Because of the scarcity of information regarding long-term follow-up of pulmonary function after whole-lung irradiation, a prospective study was started at the University of Florida in 1979 to evaluate pulmonary function after treatment with whole-lung irradiation and doxorubicin in patients with osteogenic sarcoma. PATIENTS AND METHODS Between 1979 and 1984, 57 osteogenic sarcoma patients with no evidence of metastatic disease at diagnosis received adjuvant therapy consisting of whole-lung irradiation (with the heart shielded) followed by Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH). The whole-lung irradiation schema was 1,600 cGy in 10 fractions with 8-MV x-rays via anterior and posterior fields. This was followed by five cycles of Adriamycin for a total dose of 450 mg/m2. Pulmonary function tests (PFTs) consisting of spirometry, lung volumes, and diffusing capacity were obtained before the whole-lung irradiation, at 6 and 12 months after irradiation, and at yearly intervals thereafter. RESULTS At the time of analysis, 28 of the 57 patients were available for study, with a mean follow-up of 42 months (range, 6 to 77 months). Follow-up pulmonary function testing revealed decreased forced vital capacity (FVC) and forced expiratory volume at 1 second (FEV1) during the first 6 to 12 months after whole-lung irradiation. These values returned to baseline during the second-year posttherapy and remained at baseline throughout the remainder of the follow-up period. Changes in lung volumes demonstrated a similar early trend, with significant decreases in total lung capacity (TLC) and functional residual capacity (FRC) at 6 to 12 months. These changes, however, did not improve significantly during the remainder of the follow-up period. Diffusing capacity of the lungs for carbon monoxide (DLCO) also reached a nadir at 6 to 12 months after whole-lung irradiation, with resolution by 2 years and maintenance of at least baseline values for the remainder of the follow-up period. CONCLUSIONS Treatment with whole-lung irradiation and Adriamycin, as given in this study, caused no significant sequelae, as demonstrated by pulmonary function testing during the mean follow-up period of 42 months, although a mild, transient restrictive ventilatory defect occurred at 6 to 12 months after treatment.


Author(s):  
Mathias Poussel ◽  
Isabelle Thaon ◽  
Emmanuelle Penven ◽  
Angelica I. Tiotiu

Work-related asthma (WRA) is a very frequent condition in the occupational setting, and refers either to asthma induced (occupational asthma, OA) or worsened (work-exacerbated asthma, WEA) by exposure to allergens (or other sensitizing agents) or to irritant agents at work. Diagnosis of WRA is frequently missed and should take into account clinical features and objective evaluation of lung function. The aim of this overview on pulmonary function testing in the field of WRA is to summarize the different available tests that should be considered in order to accurately diagnose WRA. When WRA is suspected, initial assessment should be carried out with spirometry and bronchodilator responsiveness testing coupled with first-step bronchial provocation testing to assess non-specific bronchial hyper-responsiveness (NSBHR). Further investigations should then refer to specialists with specific functional respiratory tests aiming to consolidate WRA diagnosis and helping to differentiate OA from WEA. Serial peak expiratory flow (PEF) with calculation of the occupation asthma system (OASYS) score as well as serial NSBHR challenge during the working period compared to the off work period are highly informative in the management of WRA. Finally, specific inhalation challenge (SIC) is considered as the reference standard and represents the best way to confirm the specific cause of WRA. Overall, clinicians should be aware that all pulmonary function tests should be standardized in accordance with current guidelines.


AAOHN Journal ◽  
1986 ◽  
Vol 34 (8) ◽  
pp. 366-369
Author(s):  
Eileen Burke-Klein

For the results of pulmonary function testing to be valid, the examination must be administered by a knowledgeable technician and the instrument must fulfill performance criteria. In general, most small to mid-sized industries rely upon local medical clinics to provide pulmonary function tests. Because of this, a survey was undertaken to study the pulmonary function testing services available at occupational medical clinics in a large metropolitan area. The purpose of this study was: 1. to determine the percentage of clinics complying with the program prerequisites mentioned above, and 2. to identify the other predictive characteristics of clinics more likely to meet these standards. A random sample of occupational medical clinics providing pulmonary function testing were selected for this study. Of the 31 clinics providing pulmonary function testing services, a random sample of 14 were chosen to perticipate; for these clinics, administrators and/or physicians were interviewed and testing equipment was examined. It was found that 17% of clinics employed certified technicians to conduct testing and 42% had instruments meeting performance specifications. Overall, only 8% of the sample met both prerequisites. No significant relationship was found between selected variables that it was hoped would identify clinics more likely to perform valid pulmonary function testing. It is believed that a larger sample size would be necessary to establish such significant correlations.


2021 ◽  
Vol 96 (3) ◽  
pp. 209-217
Author(s):  
Sung Yoon Lim ◽  
Ho Il Yoon

Spirometry, also called office-based pulmonary function testing, is a useful tool for diagnosis and classification of lung disease. Here, we outline a simple stepwise approach for interpretation of spirometry results. The first step is to determine the forced expiratory volume in a one second/forced vital capacity (FEV1/FVC) ratio. If airflow is limited, a bronchodilator is administered followed by reassessment. The next step is to determine whether FVC is low; an observed decrease in FVC indicates a restrictive patten. For patients with obstructive disease, inhalation medication is needed. Therefore, this review also describes the most appropriate inhalation device for each patient and the correct use of the device to maximize inhalation therapy benefits.


2021 ◽  
Vol 9 ◽  
Author(s):  
Sotirios Fouzas ◽  
Dimos Gidaris ◽  
Nikolaos Karantaglis ◽  
Harry Opsimos ◽  
Emmanouil I. Alexopoulos ◽  
...  

As the COVID-19 pandemic is still evolving, guidelines on pulmonary function testing that may dynamically adapt to sudden epidemiologic changes are required. This paper presents the recommendations of the Hellenic Pediatric Respiratory Society (HPRS) on pulmonary function testing in children and adolescents during the COVID-19 era. Following an extensive review of the relevant literature, we recommend that pulmonary function tests should be carried out after careful evaluation of the epidemiologic load, structured clinical screening of all candidates, and application of special protective measures to minimize the risk of viral cross infection. These principles have been integrated into a dynamic action plan that may readily adapt to the phase of the pandemic.


2011 ◽  
pp. 108-121 ◽  
Author(s):  
James R. Munis

Pulmonary function tests (PFTs) sort out the ability of the lungs to ventilate and oxygenate. Perhaps the most useful PFT measures arterial blood gas (ABG). Once we've established that the ABG is normal, it doesn't much matter whether pulmonary function is provided by a machine or is natural, nor do specific respiratory parameters (eg, tidal volume, respiratory rate, flow rate) matter as much as the end result of pulmonary function—the ABGs. The next type of PFT is spirometry, is the measurement of inhaled and exhaled lung gas. The next PFT is the flow-volume loop. Before looking at how the loop changes with pathologic conditions, you should be familiar with the axes of the graph. Note that the horizontal axis is inverted, with high volumes closer to the origin and low volumes further from the origin. Finally, the test measuring diffusing capacity of the lung for carbon monoxide (DLCO) rounds out the list of commonly used PFTs.


2016 ◽  
Vol 02 (01) ◽  
pp. 16
Author(s):  
Luís Miguel Borrego ◽  
◽  
◽  
Mário Morais-Almeida ◽  
◽  
...  

Pulmonary function tests (PFT) are usually useful to confirm the diagnosis, as well as for guidance to therapy and also to clarify the prognosis of several respiratory diseases, but only recently it gained interest in preschool aged children. Published papers have shown the feasibility of respiratory function testing in preschool aged children, as in the context of clinical investigation, as in clinical daily practice, but more investigation is needed to demonstrate PFT usefulness, particularly in clinical correlation and prospective follow-up of preschool asthmatic children.


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