scholarly journals The influence of Metisevit on biochemical and morphological indicators of blood of piglets under nitrate loading

2017 ◽  
Vol 8 (3) ◽  
pp. 427-432 ◽  
Author(s):  
B. Gutyj ◽  
K. Leskiv ◽  
A. Shcherbatyy ◽  
V. Pritsak ◽  
V. Fedorovych ◽  
...  
Keyword(s):  
Blood Serum ◽  
Sodium Nitrate ◽  
Peroxidation Of Lipids ◽  
Physiological Level ◽  
Vitamins E And C ◽  
Complex Preparation ◽  
High Doses ◽  
Hematological Indicators ◽  
And Diffusion ◽  
Liver Intoxication

The article presents the results of research on the influence of the developed complex preparation Metisevit on the dynamics of morphological and biochemical blood indicators of piglets under nitrate loading. The research established that sodium nitrate intoxication causes disbalance of the physiological level of hematological indicators of the tested animals’ organisms. This was indicated by the manifestations of subclinical chronic nitrate-nitrite toxicosis: the increase in the level of nitrates, nitrites and methemoglobin in the blood. After prolonged feeding of the piglets with sodium nitrate at a dose of 0.3 g nitrate ion/kg, the concentration of nitrates and nitrites in the blood serum reached its maximum on the 60th day of the experiment. Also, the number of leukocytes and erythrocytes in the blood increased, and the activity of aspartate- and alanineaminotransferase in the blood serum increased. We rank the extent of liver intoxication with nitrates according to intensity of aminotransferase in the blood serum of the tested piglets. The normalization of morphological and biochemical indicators of blood of piglets under nitrate-nitrite intoxication requires usage of a preparation which contains vitamins, zeolites and antioxidants. If the fodder contains high doses of nitrates, 1.0 mg/kg dose of Metisevit is added to the fodder for preventing subclinical nitrate-nitrite toxicosis. Metisevit contains the following agents: phenozan acid, methionine, zeolite, selenium, vitamins E and C. The research conducted proved the feasibility of using Metisevit for preventing chronic nitrate-nitrite toxicosis in piglets. This preparation caused a decrease in the concentration of nitrates, nitrites and in the level of methemoglobin in the blood of piglets. Usage of Metisevit on piglets showed normalization of the number of erythrocytes and hemoglobin in the blood on the 10th day, and normalization of ASAT and ALAT on 30th and 90th days. The mechanism of Metisevit activity is connected with the direct contribution of its elements to the inhibition of the processes of absorbing metabolites which cause a toxic effect on the cell membranes of an animal’s organism. The absorbing activity of zeolite leads to decrease in concentration of agents which can be substrates for processes of peroxidation of lipids in the alimentary canal, and also to elimination of toxic pro-oxidant metabolites from the blood. This process occurs through osmosis and diffusion of these elements in the capillaries of microvilli of the small intestine and through their further fixation on sorbent granules.

scholarly journals Morphological and biochemical indicators of blood of rats poisoned by carbon tetrachloride and subject to action of liposomal preparation

2017 ◽  
Vol 8 (2) ◽  
pp. 304-309 ◽  
Author(s):  
B. Gutyj ◽  
T. Martyshchuk ◽  
I. Bushueva ◽  
B. Semeniv ◽  
V. Parchenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Functional State ◽  
Total Bilirubin ◽  
Hemoglobin Content ◽  
Physiological Level ◽  
Biochemical Indicators ◽  
Liposomal Preparation ◽  
Physiological Indicators ◽  
Hematological Indicators

The article gives the results of the research on the influence of a developed complex liposomal preparation on the dynamics of morphological and biochemical indicators of the blood of rats subjected to modeled oxidative stress caused by intermuscular injection of 50% carbon tetrachloride at a dose of 0.25 ml per 100 g of body mass. We found that in conditions of intoxication by carbon tetrachloride, the physiological level of hematological indicators of the researched animals’ body was disrupted. This is indicated by the reduction in the amount of erythrocytes, hemoglobin content, concentration of hemoglobin per erythrocyte, increase in the amount of leucocytes, mass of hemoglobin per erythrocyte and increase of colour indicator. Also, we detected suppression of protein synthesis function of the liver. The levels of total protein and albumin fraction were below the normal physiological level. High indicators were observed in the levels of creatinine, urea and total bilirubin. In order to normalize the functional state of the liver under oxidative stress it is reasonable to use a liposomal preparation which contains butafosfan, interferon, thistle and vitamins. In order to normalize morphological and biochemical indicators of the blood of rats subject to intoxication of carbon tetrachloride it is reasonable to use a liposomal preparation that contains butafosfan, selenium, thistle, methionine and vitamins. Using the liposomal preparation Butaselmevit for rats under oxidative stress the morphological and biochemical indicators in the blood normalized. On the 14th day the indictors of the number of erythrocytes, the hemoglobin content, the white blood cell count and red blood indexes compared to control came within the physiological indicators, indicating a recovery of hematopoietic function of the bone marrow and normalized indicators of the functional state of the liver. 

Effect of Treatment with Activated Prothrombin Complex Concentrate (FEIBA) on Factor VIII-Antibody Level

1978 ◽  
Vol 40 (02) ◽  
pp. 478-485 ◽  
Author(s):  
K Lechner ◽  
Ch Nowotny ◽  
B Krinninger ◽  
M Zegner ◽  
E Deutsch
Keyword(s):  
Factor Viii ◽  
Antibody Level ◽  
Prothrombin Complex Concentrate ◽  
Anamnestic Response ◽  
Activated Prothrombin Complex Concentrate ◽  
Inhibitor Level ◽  
Complex Preparation ◽  
Effect Of Treatment ◽  
High Doses ◽  
Stimulation Of

SummaryThe influence of treatment with an activated prothrombin complex preparation (FEIBA) on the antibody level was studied in 10 haemophiliacs with an antibody to factor VIII. The antibody level was observed to rise at least once in five patients, while in the remaining five patients no rise occurred. In all, 6 out of 31 treatments were followed by an anamnestic rise of the antibody level, corresponding to 19.4%. A rise of the inhibitor level following FEIBA treatment is likely to occur in patients who show a marked antibody rise after factor VIII treatment (good responders), but have a low antibody level at the time of treatment. High doses of FEIBA and simultaneous transfusion of red cells may also enhance the likelihood of an anamnestic response. Stimulation of antibody production is probably due to the presence of small amounts of factor VIII in this preparation.

Periodontal disease and high doses of inhaled corticosteroids alter NTPDase activity in the blood serum of rats

2014 ◽  
Vol 59 (8) ◽  
pp. 841-847 ◽  
Author(s):  
Vanessa L. Scarabelot ◽  
Juliano Cavagni ◽  
Liciane F. Medeiros ◽  
Bernardo Detânico ◽  
Joanna R. Rozisky ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Blood Serum ◽  
Inhaled Corticosteroids ◽  
High Doses

Crystallisation and Diffusion in Oriented Sapphire Amorphised by Zinc Ion Implantation

1990 ◽  
Vol 201 ◽  
Author(s):  
L. A. Bunn ◽  
D. K. Sood
Keyword(s):  
Epitaxial Growth ◽  
Zinc Ion ◽  
High Dose ◽  
Low Doses ◽  
Surface Layers ◽  
Rapid Diffusion ◽  
High Doses ◽  
Amorphous Surface ◽  
And Diffusion ◽  
Post Implantation

AbstractHigh dose zinc implantation (1×1016 to 6×1016 ions/cm2) into c-axis sapphire at 770K produces amorphous surface layers. Post-implantation annealing at temperatures at and above 800°C show that the modes of recrystallisation are strongly dependant on ion dose. At low doses formation of crystallites of α and γ phase Al2O3 is seen, with no evidence of any planar epitaxial growth at the original crystalline-amorphous interface. The zinc is seen to diffuse isotropically within the crystallised layer and becomes partially substitutional within the crystallites. At high doses, however, the formation of crystallites is inhibited, with the layer remaining amorphous. A more rapid diffusion of zinc is seen in the amorphous Al2O3, with some of the zinc being lost at the surface.

scholarly journals Physiological level of norepinephrine increases adenine nucleotides hydrolysis in rat blood serum

2011 ◽  
Vol 7 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Bernardo Carraro Detanico ◽  
Joanna Ripoll Rozisky ◽  
Ana Maria Oliveira Battastini ◽  
Iraci Lucena da Silva Torres
Keyword(s):  
Blood Serum ◽  
Adenine Nucleotides ◽  
Physiological Level ◽  
Rat Blood

scholarly journals Changes of Some Biochemical Parameters in Rats Supplemented with High Doses of Zinc Lactate

2016 ◽  
Vol 47 (4) ◽  
pp. 148-153
Author(s):  
V. Sloup ◽  
I. Jankovská ◽  
I. Langrová ◽  
M. Štolcová ◽  
S. Sloup ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Serum ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Control Group ◽  
Feed Mixture ◽  
Serum Samples ◽  
Standard Mixture ◽  
Esterified Fatty Acids ◽  
High Doses

Abstract The experiment was conducted on 18 Wistar rats during a six-week period; 12 animals were given zinc lactate (120 mg/rat and week) in feed mixture and 6 control animals were fed a standard mixture for rats (ST-1). Sixteen biochemical parameters were measured from blood (serum) samples: total protein (TP), albumin (ALB), urea (UREA), glucose (GLU), triacylglycerols (TAG), non-esterified fatty acids (NEFA), cholesterol (CHOL), creatinine (CREAT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), uric acid (UA), magnesium (Mg), calcium (Ca), phosphorus (P), and trace elements such as Fe and Zn. When compared to the control group, we found that rats fed zinc lactate had higher concentrations of GLU, UA, UREA, Fe, Mg, Ca, TAG, TP, ALB, and ALP in the blood serum. Contrarily, the concentrations of AST, NEFA, CHOL, CREAT, P, and Zn were higher in the blood serum of control rats. Statistically significant differences between rats fed Zn and the control were found only in the concentrations of GLU, AST, ALP, UA, and P.

scholarly journals Therapeutic efficacy and pharmacological safety of parenteral supplementation of different concentrations of copper in cows

2012 ◽  
Vol 55 (1) ◽  
pp. 25-35
Author(s):  
J. R. García-Díaz ◽  
H. Munyori-Nderitu ◽  
M. Cuesta-Mazorra ◽  
R. Quiñones-Ramos ◽  
J. M. Figueredo-Ross ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Serum ◽  
Control Group ◽  
Second Phase ◽  
Hepatic Enzymes ◽  
Physiological Level ◽  
Before And After ◽  
Two Phases ◽  
The One ◽  
The Impact

Abstract. The objective of the present study was to determine the parenteral dosage of the trace mineral copper (Cu) which re-establishes serum and hepatic levels in hypocupperhemic animals without causing intoxication in the liver or residuals in milk. The experiment was carried out in two phases; in the first phase, 20 hypocupperhemic animals were used. Those were divided into 4 groups of 5 cows each: 3 groups which received 25, 50 and 100 mg of Cu respectively and 1 control group without supplementation, but with induced copraemia 5 days before and after the treatment. The milk of the cows treated with 100 mg Cu was examined for residuals of this element for one month. In the second phase, 25 animals were selected and divided into 5 groups of 5 cows each: 1 control group and 4 groups which received 25, 50, 100 and 200 mg of Cu respectively. The impact of this Cu dosages on liver reserves of this element, on hepatic enzymes (alanine-amine-transaminase, aspartate-amine-transferase, alkaline phosphatase and glutamate dehydrogenase) and on bilirubin was analyzed. The groups treated with 50 and 100 mg Cu showed increased levels in blood serum and hepatic tissues (P<0.05) in comparison to the control group and the one treated with 25 mg, obtaining the physiological level considered normal in cows during 60 days without an effect to the level of Cu in milk or to the liver’s enzymatic activity. We conclude that treatment with this dosage results in a restoration of the Cu concentration in blood serum and hepatic tissues without toxic effects or residuals.

СOMPLEMENT FOR EVALUATING THE EFFECTIVENESS OF THERAPY FOR ONCOPATOLOGY

2021 ◽  
Vol 2 (1) ◽  
pp. 23-27
Author(s):  
Knyazeva O.A. ◽  
Kireeva E.A.
Keyword(s):  
Blood Serum ◽  
Dissociation Constant ◽  
Complex Preparation ◽  
Cu And Zn

Purpose of the study. To assess changes in the comple-ment system in oncopathology (C3 (H2O) level, C1q-IgG dissociation constant) and the effect on these indicators of a complex preparation of 3d-metal gluconates (Mn, Fe, Co, Cu and Zn). It has been shown that in oncopathology (NHL, CL, BC) during incubation of blood serum, there is a change in the nature of the transition of the C3 component of the complement into its hydrolysis form C3 (H2O) and an in-crease in the dissociation constant of the C1q-IgG com-plex. After therapy with a complex preparation of 3d-metal gluconates, a correction of the C3 (H2O) level was observed. Treatment in myeloma mice had a similar effect on the hydrolysis curve of the C3 component and led to a decrease in the C1q-IgG dissociation constant. The use of these complement indicators may be promising for assessing the effectiveness of therapy.

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