Psoriasisban szenvedő betegek életminőségének                     vizsgálata Magyarországon

Abstract: Introduction: The health status and health-related quality of life (HRQoL) of patients with psoriasis in Hungary are understudied. Aim: To assess HRQoL in psoriasis patients, to compare HRQoL of psoriasis patients to that of the general public in Hungary and to identify predictors of HRQoL. Method: Between 2012 and 2016, two cross-sectional surveys were carried out among psoriasis patients at two academic dermatology departments. HRQoL was assessed by EQ-5D-3L, EQ Visual Analogue Scale (EQ VAS) and Dermatology Life Quality Index (DLQI). Predictors of HRQoL were analysed by multivariate linear regression. Results: 434 patients were enrolled (mean age 49 years, 65% male, 81% moderate-to-severe psoriasis, 43% treated with biologics). Mean EQ-5D-3L, EQ VAS and DLQI scores were 0.74 ± 0.28, 69.06 ± 20.98 and 6.78 ± 7.38, respectively. Overall, 54%, 43%, 40%, 32% and 15% of patients indicated at least some problems in pain/discomfort, anxiety/depression, mobility, usual activities and self-care. EQ-5D-3L index scores in patients were lower compared to the age- and gender-matched general population in Hungary. The difference was statistically significant for the age groups 25–34 and 45–64 in males, and 18–64 in females (p<0.05). Female gender (p = 0.042), psoriatic arthritis (p<0.001) and palmoplantar psoriasis (p = 0.031) were associated with lower EQ-5D-3L index scores. On the contrary, employed and highly educated patients reported higher EQ-5D-3L index scores (p<0.001). Conclusions: We were the first to assess HRQoL in psoriasis patients by using EQ-5D questionnaire in Hungary, and more broadly in Central and Eastern Europe. Our findings are useful for cost-effectiveness modelling of psoriasis treatments and decision-making in healthcare. Orv Hetil. 2018; 159(21): 837–846.

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Health related quality of life of rosacea patients in China assessed by DLQI and willingness to pay: Cross-Sectional Questionnaire Study (Preprint)

10.2196/preprints.24185 ◽

2020 ◽

Author(s):

Yaqun Huang ◽

Sha Yan ◽

Hongfu Xie ◽

Ben Wang ◽

Zhixiang Zhao ◽

...

Keyword(s):

Quality Of Life ◽

Willingness To Pay ◽

Disease Duration ◽

Life Quality ◽

Cross Sectional Study ◽

Health Related Quality ◽

Cross Sectional ◽

Related Quality ◽

Health Related

BACKGROUND Rosacea is a chronic inflammatory dermatosis with facial skin involved, leading to physical and emotional problems, which greatly affected quality of life (QoL) of patients. Dermatology Life Quality Index (DLQI) and willingness to pay (WTP) are well-established instruments assessing the health-related quality of life (HRQoL), while very few studies have been focused on this topic about rosacea in China. OBJECTIVE To investigate HRQoL in Chinese rosacea patients assessed by DLQI and WTP and investigate potential predictors for patients with HRQoL severely affected. METHODS This cross-sectional study was conducted on 973 patients with rosacea. Sociodemographic data, clinical features and DLQI were collected, and WTP was assessed by three standardized items. Multivariable logistic analysis was performed to investigate independent factors influencing QoL. RESULTS 921 questionnaires were accomplished by participants. The mean DLQI score was 11.6 (median 11). Patients were willing to pay an average of $1050.2 or € 896.2 (median $431.4 or € 368.1) for complete cure. 33.3% would like to pay more than 20% of their monthly income to achieve sustainable control. There were positive correlations between WTP with DLQI (P < .05). DLQI could be independently impacted by age (21-30 and 31-40, OR = 3.242 and 3.617, respectively), the occupational requirement of appearance (high, OR = 4.410), disease duration (< 2 years, OR = 1.582), oedema (OR = 1.844) and severity of flushing, burning, stinging and pruritus (severe, OR = 2.003, 1.981, 2.491, 2.249, respectively). There were no significant associations between WTP and most of the clinical factors. CONCLUSIONS The QoL was negatively affected and should not be ignored among rosacea patients in China. Patients aged 21-40y, having occupational requirement of appearance, with the disease duration less than 2 years, and suffering severe flushing and related symptoms were more likely to have severe or very severe limitation of QoL.

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Living with Migraine in Canada – A National Community-Based Study

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2019.3 ◽

2019 ◽

Vol 46 (2) ◽

pp. 216-223

Author(s):

Kristianne Chelsea Altura ◽

Scott B. Patten ◽

Jeanne V. A. Williams ◽

Kirsten M. Fiest ◽

Nathalie Jetté

Keyword(s):

Health Status ◽

Age Groups ◽

Health Utility Index ◽

Health Utility ◽

Community Based ◽

Cross Sectional ◽

Utility Index ◽

Related Quality ◽

Health Related ◽

The Impact

ABSTRACT:Objective: To develop a detailed profile of individuals living with migraine in Canada. Such a profile is important for planning and administration of services. Methods: The 2011–2012 Survey of Living with Neurological Conditions in Canada (SLNCC), a cross-sectional community-based survey, was used to examine a representative sample of migraineurs (N = 949) aged 15 years and older. Several health-related variables were examined (e.g., general health, health utility index (HUI) [a measure of health status and health-related quality of life, where dead = 0.00 and perfect health = 1.00], stigma, depression, and social support). Respondents were further stratified by sex, age, and age of migraine onset. Weighted overall and stratified prevalence estimates and odds ratios, both with 95% CIs, were used to estimate associations. Results: Overall, males had poorer health status compared with females (e.g., mean HUI was 0.67 in males vs. 0.82 in females; men had over two times the odds of their migraine limiting educational and job opportunities compared with females). Poorer health-related variables were seen in the older age groups (35–64 years/≥65 years) compared with the 15–34-year age group. There were no differences between those whose migraine symptoms began before versus after the age of 20 years. Conclusions: In this Canadian sample, migraine was associated with worse health-related variables in men compared with women. However, both men and women were significantly affected by migraine across various health-related variables. Thus, it is important to improve clinical and public health interventions addressing the impact of migraine across individuals of all ages, sexes, and sociodemographic backgrounds.

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Schistosomiasis, Upper Gastrointestinal Bleeding, and Health Related Quality of Life Measurements in Rural Africa

10.21203/rs.3.rs-42011/v1 ◽

2020 ◽

Author(s):

Christopher Kenneth Opio ◽

Francis Kazibwe ◽

Lalitha Rejani ◽

Narcis B Kabatereine ◽

Ponsiano Ocama

Keyword(s):

Upper Gastrointestinal Bleeding ◽

Female Gender ◽

Health Related Quality ◽

Disability Weights ◽

Related Quality ◽

Health Related ◽

History Of ◽

Upper Gastrointestinal ◽

Eq Vas

Abstract Introduction Health related quality of life (HRQOL) measurements, which include disability weights, are important endpoints of health care delivery. These measurements are scarce for patients with upper gastrointestinal bleeding (UGIB) in rural sub-Saharan Africa (SSA) where schistosomiasis is endemic. Methods and materials In 2014, we studied HRQOL measurements among patients with UGIB in SSA where schistosomiasis is endemic. Participants included adult inpatients and outpatients with a history of UGIB at a primary health facility. We measured HRQOL using the EuroQoL 5-dimension (EQ-VAS/EQ5D) instrument and derived disability weights from EQ-VAS and EQ5D measurements. We profiled each participant’s medical history, physical examination, laboratory tests, imaging, and endoscopy findings. These were summarized through descriptive and inferential statistics.Results We studied 107 participants with a median age of 45 years. All participants experienced ≥1 lifetime episode of UGIB, 60% were females, while 22% had acute severe UGIB requiring admission, 98% hepatic schistosomiasis, 90% splenomegaly, 80% had esophageal varices, and 20% had peptic ulcers. Most (80%) had ever received praziquantel for schistosomiasis. No participant had ever had an endoscopy for UGIB or received propranolol for prevention of recurrent variceal UGIB. Measures of the 5 dimensions of health revealed a large proportion of participants had problems related to self-care (76%), anxiety/depression (88%), and pain/discomfort (89%). Few participants had problems with mobility(37%). The mean/median EQ-VAS derived disability weights and EQ5D derived disability weights were 0.38/0.30 and 0.38/0.34, respectively. Participants with ascites, acute UGIB, and severe anemia were found to have the highest EQ-VAS and EQ5D median disability weights. At linear regression age, female gender, ascites, and acute UGIB predicted EQ-VAS derived disability weights [F(4,100)=9.35, p<0.0000,R-squared =0.27] and EQ5D derived disability weights [F(4,100)=23.24, p<0.0000, R-squared =0.44]. Within these models, all four factors were significantly predicted higher disability weights, P-value <0.05. Conclusions In our study, older age, female gender, those with ascites or acute UGIB had the highest disability weights, and the greatest probability of having higher disability weights among patients with a history of UGIB where schistosomiasis is endemic. These findings are unique and improve the definitions of different health states among patients with UGIB and schistosomiasis.

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Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data

10.21203/rs.3.rs-17191/v2 ◽

2020 ◽

Author(s):

Shao Ju ◽

Shaosong Zhou ◽

Yuan Qu ◽

bibo liang ◽

Qing-Hong Yu ◽

...

Keyword(s):

Bone Turnover ◽

Age Groups ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Age And Gender ◽

Metabolic Markers ◽

The Difference ◽

Highly Correlated ◽

And Gender

Abstract Background: Bone turnover and metabolic indicators are related to age and gender. Age and gender should be matched in subjects in disease control research of bone turnover and metabolism, but strict matching of gender and age increases the difficulty and cost of the research. Therefore, the aim of this study was to solve the question of whether it is necessary to strictly match age and gender in clinical research in bone metabolism.METHODS: Patient data were extracted from the HIS of ZhuJiang Hospital, Southern Medical University. From these data, a cross-sectional study was conducted. Data relating to seven bone turnover and metabolic indicators from 1036 patients between January 2018 and October 2019 were analyzed. A total of 156 patients aged under 20 were identified and analyzed separately. RESULTS: P1NP, β-CTx and 25(OH)D were significant different in individuals younger than 20 years of age. ALP was significantly higher in those under 20 years of age and lower at age 20-39 compared with other age groups. The concentrations of Ca and P were different among the groups aged 0-19, 20-39, and 40-59 years of age groups but exhibited no difference above 60 years of age. PTH expression was not dependent on age. P1NP, β-CTx and PTH concentrations were not significantly different between the genders within the same age group. ALP was significantly different between genders within the age range 20-59 years. Ca and 25(OH)D were significantly different between the genders for those older than 60. Serum P was significantly different in the two genders for those aged 40-79. CONCLUSION: P1NP and β-CTx were highly correlated with age. If these two indictors require analysis in a case control study, the patients and controls should be strictly matched by age under 20 years. The demarcation point for ALP was 40 years of age. Ca and P were strongly recommended strict matching according to age in disease research. The difference in P1NP, β-CTx, 25(OH)D and ALP between genders depends on age differences.

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Impact of socio-demographic and clinical characteristics on functional disability and health-related quality of life in patients with rheumatoid arthritis: a cross-sectional study from Palestine

Health and Quality of Life Outcomes ◽

10.1186/s12955-021-01874-x ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Samah W. Al-Jabi ◽

Diaa I. Seleit ◽

Adnan Badran ◽

Amer Koni ◽

Sa’ed H. Zyoud

Keyword(s):

Functional Disability ◽

Health Assessment ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

Vas Scores ◽

The Impact ◽

Eq Vas ◽

Assessment Questionnaire

Abstract Background Rheumatoid arthritis (RA) is a chronic autoimmune disorder, which has a significant impact on patients' health-related quality of life (HRQoL), and limits physical function as well as increases pain and fatigue. Therefore, this study aimed to evaluate the HRQoL and functional disability profile of patients with RA in Palestine to determine the socio-demographic and clinical features associated with low HRQoL and functional disability in patients with RA and to investigate the impact of drugs used on functional disability and HRQoL. Methodology A cross-sectional, observational study conducted at rheumatology clinics in Northern West-Bank, Palestine (Alwatani Hospital—Nablus, Khalil Suleiman Hospital—Jenin, Thabet Thatbet Hospital-Tulkarem, and Darweesh Nazzal Hospital—Qalqilia). EuroQoL-5 Dimension scale (EQ-5D-5L) was used to evaluate HRQoL, Health Assessment Questionnaire, Disability Index (HAQ-DI) to evaluate the functional disability, and the Health Assessment Questionnaire pain visual analog scale (HAQ-VAS) to evaluate pain. Results 300 patients were included in the study, 229(76.3%) were females, the mean ± standard deviation age was 49 ± 13.10 years, and the median RA duration (lower–upper quartiles) was 6 (4–12) years. The median EQ-5D-5L index value and Euro QOL visual analogue scale (EQ-VAS) scores were 0.56 and 60, respectively. There was a significant strong positive correlation (R = 0.773; p < 0.001) between the EQ-5D-5L index values and the reported EQ-VAS scores. The median HAQ-DI and HAQ-VAS were 0.94 and 40, respectively. The results of multiple linear regression showed that treatment with biological DMARD (Etanercept), having work, higher income, absence of night pain, and absence of comorbid diseases were significantly associated with higher EQ-5D-5L index score (better HRQoL) and lower HAQ-DI scores (less disability). On the other hand, older age and the presence of morning stiffness were significantly associated with higher HAQ-DI scores (more disability). Conclusions This study revealed the impact of treatment, clinical variables, and socio-demographic factors on disability and HRQoL in RA patients. Healthcare providers should be aware of the association between treatment with biological DMARD and improved HRQoL and functional status to make early interventions that reduce disability and improve HRQoL in susceptible patients.

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HEALTH RELATED QUALITY OF LIFE OF CHILDREN WITH THALA SSEMIAAT TERTIARY CARE HOSPITAL IN BELAGAVI.- A CROSS SECTIONAL STUDY

10.36106/ijsr/9534273 ◽

2020 ◽

pp. 1-2

Author(s):

Arer AR ◽

Hulagbali M

Keyword(s):

Quality Of Life ◽

Tertiary Care ◽

Age Groups ◽

Sampling Technique ◽

Care Hospital ◽

Health Related Quality ◽

Cross Sectional ◽

Related Quality ◽

Health Related

A study was conducted on 90 children suffering with thalassemia who are attending thalassemia unit of KLES Dr. Prabhakar Kore Charitable Hospital Belagavi. To assess the health related quality of life of children with thalassemia and to find out the association between health related quality of life of children with Thalassemia and selected demographic variables. Purposive sampling technique was used to select the samples. Data was collected using standardized paediatric inventory quality of life (PedsQL 4.0 Generic Core Scales) tool. Data obtained was tabulated and analysed in terms of objectives of the study using descriptive and inferential statistics. The study revealed that Majority 70 (77.78%) of thalassemia children had average level of quality of life where as minimum 10 (11.11%) of thalassemia children had low and high level of quality of life. The association between age groups and levels of QOL is found to be not statistically significant (Chi-square= 6.3530, p=0.1740) and the association between religions and levels of QOL is found to be not statistically significant.

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Evaluation of differences in health-related quality of life in patients receiving conventional versus newer anti-epileptic drugs

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20200188 ◽

2020 ◽

Vol 9 (2) ◽

pp. 342

Author(s):

Kavisha S. Goswami ◽

Devang A. Rana ◽

Shalin Shah ◽

Supriya D. Malhotra

Keyword(s):

Quality Of Life ◽

Single Point ◽

Health Related Quality ◽

Cross Sectional ◽

Male Predominance ◽

Related Quality ◽

Health Related ◽

The Difference ◽

Better Than

Background: Epilepsy is associated with stigma and bad health-related quality of life (HR-QOL) due to this, and side effects of the drug therapy. Newer anti-epileptics are claimed to be better than the conventional. We evaluated this based on comparison of HR-QOL in patients taking the respective therapy.Methods: An observational, cross-sectional, single point study involved 127 consenting patients from Neurology OPD at V.S. General Hospital. Quality of life in epilepsy-10 (QOLIE-10) questionnaire was used to measure HR-QOL in patients. SPSS software and Graphpad prism were used to analyze the variables.Results: Patients of 20-30 age group were commonly affected (37.80%) with a male predominance (56.69%). 41.73% were unemployed. The difference in HR-QOL between patients and controls in all three domains (epilepsy effects, mental effects, role function domains) of QOLIE-10 was significant (p=0.0002), indicating better HR-QOL in controls. The worst HR-QOL scores were found in Epilepsy effects domain. Metabolic adverse effects (38.58%) were the common ADRs. Sodium valproate was the most effective in controlling seizures (last seizure episode: 15 months). HR-QOL correlation between patients receiving monotherapy and polytherapy was significant (p=0.026) with monotherapy rendering a better HR-QOL. Comparison of HR-QOL between patients taking the conventional and the newer drugs was not significant (p=0.1768).Conclusions: Our study nullifies the claims that newer drugs are better than the conventional since no such benefit was seen in HR-QOL as well as ADRs. Our findings ruled out the belief that cases of epilepsy are better controlled with polytherapy.

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Frequency, Prevalence, and Burden of Flares on Patients with Moderate to Severe Psoriasis: A Retrospective Cross-Sectional Analysis

Journal of Psoriasis and Psoriatic Arthritis ◽

10.1177/247553031700200306 ◽

2017 ◽

Vol 2 (3) ◽

pp. 64-70

Author(s):

Ming-Ann Hsu ◽

James Lucas ◽

Robert Wood ◽

Joseph C. Cappelleri ◽

James Piercy

Keyword(s):

Health Status ◽

Treatment Effectiveness ◽

Life Quality ◽

Work Productivity ◽

Cross Sectional Study ◽

Severe Psoriasis ◽

Activity Impairment ◽

Cross Sectional ◽

Related Quality ◽

Health Related

Background Psoriasis impairs health-related quality of life (HRQoL). Objective To improve understanding of flare burden in patients with moderate to severe psoriasis. Methods A retrospective, cross-sectional study comparing data in U.S. patients with and without psoriasis flares. Physicians identified flaring patients as those not in remission, or in remission < 12 weeks, with worsening/unstable disease progression. Results Overall health status (EQ-5D-3L) was reduced in flaring versus matched non-flaring patients ( P = .001); this difference was clinically meaningful (> 0.074 difference in absolute value). Reduced HRQoL and activity impairment, measured by Dermatology Life Quality Index ( P = .0178) and Work Productivity and Activity Impairment Questionnaire ( P = .0002), respectively, were observed in flaring versus non-flaring patients. Anxiety was associated with flaring ( P = .0139). Flaring patients were less satisfied with treatment effectiveness than non-flaring patients ( P < .0001). The flaring group experienced a median of two flares over 12 months. Conclusion Flares are associated with reduced health status and HRQoL and lower treatment satisfaction.

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Impact of Hypoglycemia on Health-Related Quality of Life among Type 2 Diabetes: A Cross-Sectional Study in Thailand

Journal of Diabetes Research ◽

10.1155/2019/5903820 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Thongchai Pratipanawatr ◽

Bancha Satirapoj ◽

Boonsong Ongphiphadhanakul ◽

Sompongse Suwanwalaikorn ◽

Wannee Nitiyanant

Keyword(s):

Cross Sectional Study ◽

Health Related Quality ◽

Sectional Study ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

Eq Vas ◽

One Way Anova

Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. Patients are generally advised lifestyle changes with antihyperglycemic agents prescribed. The major drawback of prescribing antihyperglycemic agents is the risk of hypoglycemia which subsequently impacts on health-related quality of life (HRQoL). This study is aimed at examining association between previous history of hypoglycemia and HRQoL. The study was a multicenter cross-sectional study, conducted from February 2013 to March 2015 at 5 tertiary care hospitals in Thailand (Srinagarind, Phramongkutklao, Ramathibodi, King Chulalongkorn Memorial, and Siriraj hospitals). The study population were males or females diagnosed with type 2 DM according to ADA criteria, 30 years of age or older, who had been treated with sulfonylurea (SU) monotherapy or SU and metformin combination for at least 6 months. Prespecified medical factors were extracted from medical records 12 months prior to patients’ enrolment. The experience of hypoglycemia questionnaire was used to collect and measure severity of hypoglycemia experienced during the previous 6 months. HRQoL was assessed using the 3-level version of EuroQol-5-dimension (EQ-5D-3L) and visual analogue scale (EQ-VAS) questionnaires. Of 659 eligible patients surveyed, 202 patients (30.65%) had experienced symptoms of hypoglycemia. HRQoL was significantly lower among patients reporting at least one of hypoglycemic symptoms, measured by EQ-VAS scores (mean±SD; 73.66±13.18, 73.56±15.10, or 68.93±14.76 vs. 77.01±13.02, one-way ANOVA; p=0.006) and EQ-5D-3L index scores (0.62±0.47, 0.68±0.38, or 0.58±0.51 vs. 0.79±0.31, one-way ANOVA; p<0.001) for mild, moderate, or severe/very severe hypoglycemic patients compared with patients without hypoglycemic symptoms. After adjusting for confounding factors in a multiple linear regression model, patients with hypoglycemic symptoms either mild, moderate, or severe/very severe demonstrated significantly higher impairment for EQ-VAS and EQ-5D indexes than those who did not experience hypoglycemic symptoms. In conclusion, our study showed decreased HRQoL determined by EQ-5D and EQ-VAS in patients reporting symptoms of hypoglycemia compared with patients not reporting hypoglycemic symptoms, relative to severity of hypoglycemia.

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The study of epidemiological correlates of hypertension among the rural population of Mehsana district of North Gujarat region, India

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20214790 ◽

2021 ◽

Author(s):

Nilesh Thakor ◽

Pankaj B. Nimbalkar ◽

Maulik D. Joshi

Keyword(s):

Blood Pressure ◽

Rural Areas ◽

Rural Population ◽

Age Groups ◽

Cross Sectional Study ◽

Cross Sectional ◽

Economic Class ◽

The Difference ◽

And Gender ◽

North Gujarat

Background: The changing lifestyle factors in rural population are associated with increase in hypertension. Objective was to find out the epidemiological correlates of hypertension among the rural population.Methods: This was cross sectional study and conducted in rural areas of Mehsana district of Gujarat during January 2019 to June 2019. People living rural areas were selected by stratified random sampling. They were screened for hypertension by JNC VII criteria using sphygmomanometer and detailed personal, past and family history was taken after written and informed consent. Data was entered in Microsoft excel and analysis was done using SPSS statistical package.Results: Out of total 602 subjects, 93 (15.4%) were hypertensive. Out of total 93 hypertensive subjects, 50 (53.8%) were females. A blood pressure category and gender difference were not statically significant (p=0.89). Out of 93 hypertensive subjects, 42 (45.2%) subjects were in the age group of ≥60 years. The difference between age groups and blood pressure category was significant (p<0.0001). Out of 93 hypertensive subjects’ majority 85 (91.4%) had negative tobacco history while only 8 (8.6%) consumed tobacco in any form. The tobacco history and blood pressure category were not significantly associated (p=0.211). Out of total 93 hypertensive subjects, 54 (58.1%) subjects were (≥25) body mass index (BMI). Categories of BMI and hypertension were extremely significantly associated (p<0.0001).Conclusions: Hypertension is significantly associated with age, socio economic class and BMI.

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