Consensus on the change of criteria for cure of acromegaly during the last decade

The Acromegaly Consensus Group redefined the consensus criteria for cure of acromegaly. 74 neurosurgeons and experienced endocrinologists summarized the latest results on diagnosis and treatment of acromegaly. In this consensus statement the reliable growth hormone and insulin-like growth factor-1 assays were established. Definition of disease control was discussed based on the available publications and evidence. This short communication summarizes the clinical aspects of consensus criteria for diagnosis and cure of acromegaly based on the original article. Orv. Hetil., 2011, 152, 703–708.

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Measurement of growth hormone, insulin-like growth factor I and their binding proteins: the clinical aspects

Clinica Chimica Acta ◽

10.1016/s0009-8981(01)00662-3 ◽

2001 ◽

Vol 313 (1-2) ◽

pp. 119-123 ◽

Cited By ~ 15

Author(s):

Kin-Chuen Leung ◽

Ken K.Y Ho

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Binding Proteins ◽

Clinical Aspects ◽

Insulin Like Growth Factor ◽

Factor I ◽

Growth Factor I

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Consensus Statement on the Standardization and Evaluation of Growth Hormone and Insulin-like Growth Factor Assays

Clinical Chemistry ◽

10.1373/clinchem.2010.150631 ◽

2011 ◽

Vol 57 (4) ◽

pp. 555-559 ◽

Cited By ~ 191

Author(s):

David R Clemmons

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Normative Data ◽

Consensus Statement ◽

International Workshop ◽

Research Society ◽

Insulin Like Growth Factor ◽

Gh Secretion ◽

Assay Performance ◽

Igf I

Abstract Growth hormone (GH) and insulin-like growth factor I (IGF-I) measurements are widely used in the diagnosis of disorders of GH secretion, evaluation of children with short stature from multiple causes, management of disorders that lead to nutritional insufficiency or catabolism, and monitoring both GH and IGF-I replacement therapy. Therefore, there is an ongoing need for accurate and precise measurements of these 2 peptide hormones. Representatives of the Growth Hormone Research Society, the IGF Society, and the IFCC convened an international workshop to review assay standardization, requirements for improving assay comparability, variables that affect assay interpretation, technical factors affecting assay performance, assay validation criteria, and the development and use of normative data. Special attention was given to preanalytical conditions, the use of international commutable reference standards, antibody specificity, matrix requirements, QC analysis, and interference by binding proteins. Recommendations for each of these variables were made for measurements of each peptide. Additionally, specific criteria for IGF-I were recommended for age ranges of normative data, consideration of Tanner staging, and consideration of the effect of body mass index. The consensus statement concludes that major improvements are necessary in the areas of assay performance and comparability. This group recommends that a commutable standard for each assay be implemented for worldwide use and that its recommendations be applied to accomplish the task of providing reliable and clinically useful results.

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