Birth marks and neonatal skin disorders. From angel kiss to epidermolysis bullosa

2014 ◽  
Vol 155 (13) ◽  
pp. 500-508 ◽  
Author(s):  
Zsanett Csoma ◽  
Angéla Meszes ◽  
Rita Ábrahám ◽  
Judit Bakki ◽  
Zita Gyurkovits ◽  
...  
Keyword(s):  
Newborn Infants ◽  
Vascular Lesions ◽  
Whole Body ◽  
Special Treatment ◽  
Skin Disorders ◽  
Cutaneous Lesions ◽  
Developmental Abnormalities ◽  
Pigmented Lesions ◽  
Mongolian Spot ◽  
Neonatal Skin

Introduction: At present there are no exact epidemiologic data on the prevalence of neonatal skin disorders and birth marks in Hungary. Aim: The aim of the authors was to investigate the prevalence of skin disorders in mature healthy neonates after birth. Method: The survey was carried out in the Neonatal Care Unit at the Department of Obstetrics and Gynaecology at the University of Szeged between April, 2012 and May, 2013. Results:A total of 2289 newborn infants underwent whole-body screening skin examinations. At least one skin manifestation was found in 63% of the neonates. The major groups of skin disorders were transient benign cutaneous lesions, vascular lesions, pigmented lesions, traumatic, iatrogenic, congenital or acquired disorders with skin injuries, developmental abnormalities and benign skin tumours. The most frequent transient cutaneous lesions were erythema toxicum neonatorum, sebaceous hyperplasia and desquamation. The most common vascular lesions were naevus simplex, haemangioma and haemangioma precursor lesion, while the most frequently observed pigmented lesions were congenital melanocytic naevi and Mongolian spot. Conclusions: In the vast majority of cases, special treatment was not necessary, but 5.27% of the neonates required local dermatologic therapy, and in 9.2% of neonates follow up was recommended. Orv. Hetil., 2014, 155(13), 500–508.

scholarly journals Subconjunctival Hemorrhage in a Child with the Blue Rubber Bleb Nevus Syndrome on Treatment with Oral Propranolol

2021 ◽  
pp. 451-456
Author(s):  
Karen De Loecker ◽  
Veerle Labarque ◽  
Hilde Seynaeve ◽  
Ingele Casteels
Keyword(s):  
Central Nervous System ◽  
Topical Treatment ◽  
Vascular Lesions ◽  
Venous Malformations ◽  
Timolol Maleate ◽  
Cutaneous Lesions ◽  
Subconjunctival Hemorrhage ◽  
First Case ◽  
Β Blocker ◽  
Oral Propranolol

Blue rubber bleb nevus syndrome (BRBNS) is a rare syndrome characterized by venous malformations of mostly skin and gastrointestinal tract. Patients present with multiple venous malformations in various organs including liver, spleen, heart, eye, and central nervous system. Few ophthalmological cases have been published in literature and at present, there are no clear guidelines on the treatment of eye hemorrhages associated with the BRBNS. We report a 3-year-old boy with the BRBNS who developed a spontaneous progressive enlarging subconjunctival hemorrhage in the left eye despite being treated with oral propranolol. The subconjunctival hemorrhage was caused by an underlying conjunctival vascular malformation. With topical treatment with timolol maleate 0.5% once a day in the affected eye, the lesion regressed completely after 4 months. This child represents the first case of the BRBNS associated with a subconjunctival progressive bleeding necessitating topical treatment despite oral propranolol effectively controlling the cutaneous lesions. We recommend ophthalmic screening of patients with BRBNS in early childhood. For patients with BRBNS-related subconjunctival vascular lesions with subsequent hemorrhage, treatment with a topical β-blocker may be an efficient and harmless treatment option.

Neurotoxicity of Hexachlorophene in the Human: I. A Clinicopathologic Study of 248 Children

PEDIATRICS ◽  
1974 ◽  
Vol 54 (6) ◽  
pp. 689-695
Author(s):  
Robert M. Shuman ◽  
Richard W. Leech ◽  
Ellsworth C. Alvord
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Newborn Infants ◽  
Whole Body ◽  
Human Beings ◽  
Term Neonates ◽  
Experimental Animals ◽  
Clinicopathologic Study ◽  
Neurotoxic Effects ◽  
Sick Children

To assess the susceptibility of human beings to the neurotoxic effects of hexachlorophene demonstrated in experimental animals, a blind clinicopathologic analysis was made of 248 children coming to autopsy over a 7.5-year period in the two Seattle institutions to which practically all premature or sick children are referred. Repeated whole-body bathing of premature newborn infants in 3% hexachlorophene-bearing soap (undiluted pHisoHex) is associated with a vacuolar encephalopathy of the brainstem reticular formation. The prevalence of the vacuolar encephalopathy appears to be related to the number of exposures to hexachlorophene, to the concentration of hexachiorophene, to the birth weight (gestational age), to the length of survival and to the thoroughness of rinsing. From these observations we conclude that hexachlorophene should not be used on neonates under 1,400 gm birth weight and should be used only sparingly in full-term neonates with thorough rinsing.

scholarly journals New trends in botulinum toxin use in dermatology

2018 ◽  
pp. 277-282 ◽  
Author(s):  
Stefania Guida ◽  
Francesca Farnetani ◽  
Steven P. Nisticò ◽  
Caterina Giorgio Mariarosaria ◽  
Graziella Babino ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Neurotoxin ◽  
Current Knowledge ◽  
Hypertrophic Scars ◽  
Skin Disorders ◽  
Facial Flushing ◽  
Cutaneous Lesions ◽  
Raynaud Phenomenon ◽  
Skin Conditions ◽  
Review Current

Background: Recent studies have highlighted new botulinum neurotoxin (BoNT) applications in the field of dermatology. Objective: To review current knowledge of BoNT use in dermatology. Methods: The literature of the last 5 years has been reviewed. Results: We describe interesting protocols of BoNT treatment for hyperhidrosis (HH), hypertrophic scars and keloids, Raynaud phenomenon, facial flushing, oily skin, psoriasis, Hailey-Hailey disease, and cutaneous lesions like painful lesions and periorbital syringomas. Conclusions: Several skin conditions eligible for BoNT treatment have been described. After the wide application for HH treatment, scars as well as vascular and inflammatory skin disorders, oily skin and cutaneous lesions represent fields of application of BoNT.

scholarly journals Cutaneous Vascular Anomalies Associated With Neural Tube Defects: Nomenclature and Pathology Revisited

Neurosurgery ◽  
2011 ◽  
Vol 69 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Todd Maugans ◽  
Rachel M Sheridan ◽  
Denise Adams ◽  
Anita Gupta
Keyword(s):  
International Society ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Vascular Malformations ◽  
Strong Association ◽  
Vascular Anomalies ◽  
Vascular Lesions ◽  
Dermal Sinus ◽  
Cutaneous Lesions ◽  
Glut 1

Abstract BACKGROUND: Lumbosacral cutaneous vascular anomalies associated with neural tube defects are frequently described in the literature as “hemangiomas.” The classification system for pediatric vascular anomalies developed by the International Society for the Study of Vascular Anomalies provides a framework to accurately diagnose these lesions. OBJECTIVE: To apply this classification to vascular cutaneous anomalies overlying myelodysplasias. METHODS: A retrospective analysis of patients with neural tube defects and lumbosacral cutaneous vascular lesions was performed. All eligible patients had detailed histopathologic analysis of skin and spinal cord/placode lesions. Clinical and radiologic features were analyzed. Conventional histology and GLUT-1 immunostaining were performed to differentiate infantile capillary hemangiomas from capillary vascular malformations. RESULTS: Ten cases with cutaneous lesions associated with neural tube defects were reviewed. Five lesions were diagnosed as infantile capillary hemangiomas based upon histology and positive GLUT-1 endothelial reactivity. These lesions had a strong association with dermal sinus tracts. No reoperations were required for residual intraspinal vascular lesions, and overlying cutaneous vascular anomalies involuted with time. The remaining 5 lesions were diagnosed as capillary malformations. These occurred with both open and closed neural tube defects, did not involute, and demonstrated enlargement and darkening due to vascular congestion. CONCLUSION: The International Society for the Study of Vascular Anomalies scheme should be used to describe the cutaneous vascular lesions associated with neural tube defects: infantile capillary hemangiomas and capillary malformations. We advocate that these lesions be described as “vascular anomalies” or “stains” pending accurate diagnosis by clinical, histological, and immunohistochemical evaluations.

Lumps and bumps

2018 ◽  
Author(s):  
Rubeta Matin ◽  
Jane McGregor ◽  
Catherine Harwood
Keyword(s):  
Primary Care ◽  
Lymph Node ◽  
Internal Source ◽  
Cutaneous Lesions ◽  
Pigmented Lesions ◽  
Skin Cancers ◽  
Common Causes ◽  
Skin Tags ◽  
Low Threshold ◽  
Melanoma Skin

A skin ‘lump or bump’ is taken here to refer to a lesion on the skin that an individual recognizes as something new or unusual. It comprises a heterogeneous group and presents in many guises, usually to primary care. Common causes of ‘lumps and bumps’ include warts, moles, skin tags, dermatofibromas, lipomas, epidermoid cysts, and, of course, melanoma and non-melanoma skin cancers. Distinguishing malignant from non-malignant is not always straightforward. Maintaining a low threshold for referral into secondary care is wise, especially for pigmented lesions, but also for those lesions where there is no obvious diagnosis. Occasionally, a lump in the skin may have arisen from an internal source, such as a metastasis or lymph node. This chapter describes only primary cutaneous lesions and classifies them according to their origin.

Cryostimulation of whole body as a possible supportive biological approach in mild cognitive impairments

2016 ◽  
Vol 33 (S1) ◽  
pp. S95-S95
Author(s):  
J. Rymaszewska ◽  
D. Szczesniak ◽  
U. Katarzyna ◽  
T. Elzbieta ◽  
S. Bartlomiej
Keyword(s):  
Cognitive Impairments ◽  
Vascular Lesions ◽  
Whole Body ◽  
Inflammatory Processes ◽  
Competing Interest ◽  
Future Evaluation ◽  
Therapy Strategies ◽  
Whole Body Cryotherapy ◽  
Experimental Group

BackgroundLimitations of available treatment methods of dementia imply constant need to search for new, supplementary therapy strategies. There is a consensus that vascular lesions, oxidative stress, inflammatory processes and abnormal neurotransmission are associated with dementia. Due to the anti-inflammatory (modification of pro-inflammatory cytokines concentration), antioxidative effect of cryogenic temperatures as well as the hormonal and lipid changes, they may play an important role in preventing or inhibiting pathophysiological processes.AimTo assess the influence of whole-body cryostimulation on cognitive functions of patients with MCI.MethodsRCT design is used to examine the influence of whole-body cryotherapy (WBC) on people with mild cognitive impairments (MCI) with the evaluation of psychometric, somatic and laboratory parameters. Participants undergo 10 sessions each day of 2–3 min of WBC in experimental group (−110 till −160 °C) and placebo (−20 °C). The CDR, MoCA, TYM, DemTect and SLUMS scales are used among others at baseline and follow-up. Preliminary data of 7 volunteers (n = 7, 49–79 years old) were presented. Results on Fig. 1.DiscussionAmong obtained psychometric results show that all, except of one, patients significantly improved their scores after WBC. That is a very promising feedback for future evaluation of WBC effectiveness in prevention of dementia in patients with MCI.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Pigmented lesions in newborn infants

1976 ◽  
Vol 95 (4) ◽  
pp. 389-396 ◽  
Author(s):  
ROBERT G. WALTON ◽  
ALVIN H. JACOBS ◽  
ALVIN J. COX
Keyword(s):  
Newborn Infants ◽  
Pigmented Lesions
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