Study for the Interfacial Effect between a Crawling Cell and a
Substrate on Chemotaxis
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ABSTRACTChemotaxis is one of the essential mechanisms responsible for various complex biological processes. For a crawling cell, the interface between the cell and the substrate plays an important role in the chemotactic migration. This paper presents a three-dimensional dynamic model to investigate the effect of the interface between a crawling cell and a substrate on its chemotaxis. The coupled mechanisms of chemotaxis, the surface energy of the cell, and the interface between the cell and the substrate are incorporated into a diffuse interface model. Simulations reveal rich dynamics of a crawling cell associated with the interfacial condition, and confirm the high possibility of adequate predictions.
2017 ◽
Vol 137
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pp. 246-265
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2005 ◽
Vol 53
(18)
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pp. 4755-4764
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2014 ◽
Vol 272
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pp. 25-40
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2016 ◽
Vol 27
(3)
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pp. 847-872
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